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Showing 1 to 2 of 2 for “"Phage engineering"”.
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Determining the mechanism of protein transit through the peptidoglycan layer in Gram-positive bacteria and identifying phage-docking sites on Clostridium perfringens
… the cells. For both routes of infection, bacteriophages could supplement or entirely replace antibiotics. This could help greatly reduce the amount of collateral damage to the microbiome in gastrointestinal infection due to high phage specificity. A more speculatory approach is administering …
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Elucidation of an oral drug delivery mechanism to the mammalian gastrointestinal tract via an engineered T4 phage
… as vectors for biologic delivery, yet cellular engineering approaches have traditionally lowered fitness and colonization potential of these microbial factories. As a result, recombinant bacteria are often outcompeted by the native gut flora, requiring high concentrations to alleviate disease …