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Showing 1 to 19 of 19 for “"PhIP"”.
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Untersuchungen zur chemischen Transformation von intestinalen Epithelzellen der Ratte und des Menschen durch 2-Hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridin
… gehört das heterozyklische aromatische PhIP, das bei der Erhitzung proteinreicher Nahrungsmittel entsteht. Neben zahlreichen Fütterungsversuchen an Nagern existieren auch Zellkulturmodelle zur Untersuchung der molekularen Mechanismen der PhIP-induzierten Kolonkanzerogenese. Die chemische …
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Inhibitory effect of edible films and coatings containing selected amino acids on the formation of 2-amino-1-methyl-6-phenylimidazo[4-5-b]pyridine (PhIP) in pan-fried chicken breasts
… [4,5-b] pyridine (PhIP) in chicken breasts and to evaluate the physicochemical properties of the chicken. Heated whey protein isolate (HWPI) solution (100g ) was made by heating 5 g whey protein isolate (WPI) solution at 90 ºC for 30 min (in a water bath). After …
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Histologische und molekulargenetische Analyse von Darmgeweben aus mit dem humanrelevanten Kanzerogen 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) behandelten F344-Ratten
… 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridin (PhIP) aus der Substanzklasse der heterozyklischen aromatischen Amine. Es entsteht bei der Erhitzung zahlreicher proteinhaltiger Nahrungsmittel und die Zielorgane in Nagerstudien stimmen mit der Häufung von Krebsinzidenzen in westlichen …
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Cobalt catalysts towards parahydrogen induced polarization
… the field of Parahydrogen Induced Polarization (PHIP) to yield large signal enhancements over the standard signals traditionally achieved in MRI and NMR spectroscopy. This field has advanced to yield enhancements via both hydrogenative (incorporation of p-H2 into the substrate) and …
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In vitro chemically-induced DNA damage in cancer patients and healthy individuals. The effect of genotoxic compounds in cells from polyposis coli, colon cancer patients and healthy individuals.
… chromatid exchange assay. The food mutagens, PhIP and IQ, as well as titanium dioxide nanoparticles (TiO2 NPs) induced a dose dependent increase in the DNA damage and chromosomal abnormalities in all tested groups regardless of confounding factors. Prior to experiments physicochemical …
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The catalytic hydrogenation of carbon-carbon and carbon-nitrogen multiple bonds by a cobalt(I) complex
… and parahydrogen (p-H2) induced polarization (PHIP) transfer NMR reveled a Co(I)/Co(III) redox process was operative. Based on the mechanistic studies of the olefin hydrogenation studies, the hydrogenation utility of (MesCCC)Co(N2)(PPh3) was extended toward the semi-hydrogenation of a broad …
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Estrategias dietéticas para contrarrestar el impacto de la ingesta de xenobióticos sobre la microbiota intestinal y el sistema inmune
… el consumo de xenobióticos en un modelo animal PhIP+DSS.
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Konstruktion und toxikologische Nutzung von transgenen Mäusen mit den allelischen Varianten von humanen SULT1A-Genen
… 2-Amino-1-methyl-6-phenylimidazo-[4,5-b]pyridin (PhIP) verwendet. PhIP wird beim Erhitzen und Braten von Fleisch und Fisch gebildet und könnte mit der erhöhten Krebsentstehung im Colon in der westlichen Welt im Zusammenhang stehen. Mittels 32P-Postlabelling sollte der Einfluss der zusätzlichen …
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NMR/MRI SIGNAL ENHANCEMENT BY REVERSIBLE EXCHANGE (SABRE) AND HETEROGENEOUS SABRE (HET-SABRE)
… by Reversible Exchange, or SABRE, is a type of PHIP (ParaHydrogen Induced Polarization) pioneered by Duckett, Green, and co-workers where an organometallic catalyst is used to co-locate parahydrogen (pH2) and a molecular substrate to be hyperpolarized. Like traditional PHIP, SABRE is of interest …
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Development of Pd Catalyzed Amidations & Applications to the Synthesis of Heterocycles
… as the total synthesis of the mutagen 1-Me-5-PhIP.</p> <p>This reaction was then further explored to utilize more readily available catalytic components and to increase the substrate and amide scope.</p> <p>Chapter 3</p> <p>The C2 amination of imidazo[4,5-b]pyridines was accomplished through …
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Inhibitory Effects of Isothiocyanates on the Mutagenicity and Metabolism of Environmental Carcinogens
… amines (HCAs) IQ, MelQx, Trp-P-2, Glu-P-2 and PhIP and on the dealkylation of ethoxyresorufin (EROD) and methoxyresorufin (MROD) were investigated. All four isothiocyanates significantly inhibited the oxidation of NNK by hamster liver microsome. The isothiocyanates enhanced the reduction of NNK …
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Molecular display of synthetic oligonucleotide libraries and their analysis with high throughput DNA sequencing
… called phage immunoprecipitation sequencing (PhIP-Seq). In a proof-of-concept study, this method identified both known and novel autoantibodies contained in the spinal fluid of a control patient with paraneoplastic neurological syndrome. The study was then expanded to include a large scale …
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Innate and humoral immune responses to HIV-1
… to phage-displayed human peptidomes (PhIP-Seq). While 4E10 is demonstrably autoreactive, GEPs exhibited a distinct profile of autoantigen recognition by PhIP-Seq, suggesting that autoreactivity was acquired during ontogeny. In many respects, 4E10 provides a divergent example of Ab …
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Cyclization of reactive carbonyls in foods upon processing: an origin for the formation of pyridine-derived flavours and heterocyclic aromatic amines
… 2-amino-1-metil-6-fenilimidazo[4,5-b]piridina (PhIP) es una HAA mayoritaria que se produce como consecuencia de la reacción de ciertos compuestos carbonílicos formados durante el procesado de alimentos con creatinina. Análogamente, otras HAAs con estructura de aminoimidazoazareno podrían …
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NOVEL EXPERIMENTAL APPROACHES AND THEORETICAL MODELS FOR IMPROVING SENSITIVITY AND INFORMATION CONTENT OF NMR AND MRI SPECTROSCOPY
… experiments. Parahydrogen-induced polarization (PHIP) is an emerging field in enhancing the sensitivity in NMR experiments and may play an important role in MRI studies. Within this field a very recent phenomena of signal amplification by reversible exchange (SABRE) was investigated. The …
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Molecular mechanisms of myricetin bulk and nano forms mediating genoprotective and genotoxic effects in lymphocytes from pre-cancerous and myeloma patients
Cancer is one of the leading causes of death across the globe which needs appropriate and cost-effective treatment. Several recent studies have suggested that dietary intake of various flavonoids such as myricetin have a protective effect against different types of cancers and cardiovascular …
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Konstruktion und Charakterisierung transgener Mauslinien für humane Sulfotransferasen als Modellsysteme für eine SULT-vermittelte metabolische Aktivierung
Die Enzyme der Sulfotransferase-Gensuperfamilie (SULT) konjugieren nukleophile Gruppen von kleinen endogenen Verbindungen und Fremdstoffen mit der negativ geladenen Sulfo-Gruppe. Dadurch wird die Polarität dieser Verbindungen erhöht, ihre passive Permeation von Zellmembranen verhindert und somit …