Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Ph-like"”.
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Genomics, Diagnosis, Novel Targeted Therapies and Characterisation of the Drivers of Relapse in Philadelphia Chromosome-Like Acute Lymphoblastic Leukaemia
This thesis focuses on Philadelphia chromosome-like (BCR::ABL1-like) acute lymphoblastic leukaemia (Ph-like ALL), a subtype of B-cell ALL recently recognised as a distinct entity. The genomic drivers of Ph-like ALL are diverse. This thesis emphasises investigation of the JAK/STAT class of lesions. …
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The Heme-Regulated Inhibitor Pathway Modulates Susceptibility of Poor Prognosis B-Lineage Acute Leukemia to BH3-Mimetics
… in mouse and human leukemia including both Ph+ and Ph-like B-ALL. Lastly, combinatorial treatment of leukemia bearing mice with both BTdCPU and a BH3-mimetic extended survival and repressed MCL-1 in vivo. These findings reveal that the HRI-dependent cellular heme-sensing pathway can modulate …
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Análisis de la glicoproteina B de los Alphaherpesvirus bovinos 1 y 5 como candidata vacunal contra la rinotraqueitis infecciosa bovina
… se seleccionaron los dominios denominados PH Like 1 del BoHV-1 y PH Like 2 del BoHV-5 para el diseño de un candidato vacunal bivalente. El estudio inmunoinformático de esta quimera candidata mostró que estos dos dominios tienen epítopos conformacionales y lineales reconocibles por los …