Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 46 for “"Pgp"”.
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Evaluation of an Orthotic Intervention for the Management of Pregnancy Related Pelvic Girdle Pain (PGP)
… antenatal and post-partum pelvic girdle pain (PGP). In the first instance the fabric, from which the DEFO was constructed, underwent testing to determine if the different colour fabrics available possessed the same underlying fabric stiffness and elastic hysteresis to ensure that each orthotic …
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Understanding the Impact of BCRP and PGP Efflux Transporters on the Disposition of Their Endogenous, Xenobiotic and Dietary Substrates
… Resistant Protein (BCRP) and P-glycoprotein (PGP) are membrane-bound efflux transporters that transport multiple chemical classes of compounds and act as barriers to tissue permeability, thereby regulating tissue exposure of their substrates. The role of these transporters in therapeutic …
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A mixed method Delphi study to determine professional consensus on the key elements of outpatient Psychodynamic Group Psychotherapy (PGP) for psychosis
Although psychodynamic group psychotherapy (PGP) has been offered to patients with psychosis for over a century there is little empirical evidence of its effectiveness. In part this has to do with the lack of a consistent and adequately robust definition of this intervention. The aims of this study …
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Novel Use of Dual Anti-Inflammatory Therapy to Overcome Drug Resistance and Improve Functional Recovery Following Spinal Cord Injury
… short in clinical trials.</p> <p>P-glycoprotein (Pgp) is an active transporter expressed on capillary endothelial cell membranes at the blood-spinal cord barrier (BSCB). Pgp limits passive diffusion of blood-borne drugs into the CNS, by actively extruding drugs from the endothelial cell membrane. …
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Charakterisierung der Abspaltung und des Schicksals der Signalsequenz des Glykoproteins des lymphozytären Choriomeningitis Virus
… Choriomeningitis Virus (LCMV) Glykoproteins pGP-C (SSGP-C) untersucht. In einem zellfreien in vitro Translations-/Translokationssystem wurde ein Fusionsprotein, das aus der SSGP-C und dem reifen Teil des zellulären sekretorischen Proteins pre-Prolaktin besteht, nach dem zielgerichteten …
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P-glycoprotein and membrane permeability as determinants of xenobiotic bioavailability and bioaccumulation
The ABC transporter P-glycoprotein (Pgp) and membrane permeability are determinant factors for absorption and disposition of xenobiotics. These studies investigated the effects of potential modulators of Pgp and/or membrane function on the disposition, bioavailability and bioaccumulation of …
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The Role of Multi-Drug Resistance Associated Protein 4 and P-glycoprotein in Resistance of Neuroblastoma to Topotecan and Irinotecan
… cassette (ABC) transporters P-glycoprotein (Pgp) and multidrug resistance associated protein 1 (MRP1), which efflux many drugs used in neuroblastoma therapy, has been implicated in poor outcome in neuroblastoma. Therefore, the purpose of our studies was to determine the role of ABC transport …
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Contextos de formação de pequenos grupos de pesquisas nas escolas: as questões sociocientíficas como eixo necessário para formação de professores
… e constituição de um Pequeno Grupo de Pesquisa (PGP) em escolas públicas. Entendemos por PGP um grupo formado por professores, gestores de escolas e pós-graduandos em que são valorizados processos de tematização e problematização da realidade escolar. Em outras palavras, o PGP se constitui como …
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Estrategias innovativas y competitividad de las firmas del sector metalmecánico del Partido de General Pueyrredon, en el período postconvertibilidad
… (IM) PYME del Partido de General Pueyrredon (PGP) en el contexto macroeconómico post-convertibilidad, identificando clusters según las estrategias innovativas implementadas por las firmas que componen el sector y analizando el desempeño de cada uno. La investigación es descriptiva y …
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Synthesis of furo[2,3-d]pyrimidines, thieno[2,3- d]pyrimidines, pyrrolo[2,3-d]pyrimidines as classical and nonclassical antifolates, receptor tyrosine kinase (RTK) inhibitors and antimitotic agents
… for the treament of various types of cancer s. Pgp overexpression is one of the common reasons for drug resistance to existing antitumor agents and consequently the reason for some chemotherapeutic failures. A furo[2,3- d ]pyrimidine compound was discovered to have dual RTK inhibitory activity …
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Certificación de calidad y mejora continua: oportunidades para fortalecer la competitividad de las empresas industriales del Partido de General Pueyrredon
… a las firmas del Partido de General Pueyrredon (PGP) en base a ambas prácticas. Se trata de una investigación de alcance descriptivo, en la cual se aplica Análisis de Correspondencias Múltiples (ACM) para construir perfiles de empresas. La fuente de datos es secundaria y corresponde a una …
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Relación entre el perfil de diversificación productiva y el desempeño competitivo en la industria del Partido de General Pueyrredon
… industriales del Partido de General Pueyrredon (PGP). El diseño de investigación es de tipo explicativo, y se aplican técnicas de análisis cuantitativas. En primer lugar, se elaboran perfiles de empresas en relación con su condición diversificadora, a partir de un análisis de correspondencias …
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Capacidad de absorción de conocimiento y articulación productiva en la industria del Partido de General Pueyrredon
… la industria del Partido de General Pueyrredon (PGP) y analizar su relación con la capacidad de absorción de conocimiento de las empresas locales. El diseño de investigación es cuantitativo y de alcance explicativo. La fuente de datos es una encuesta realizada a 244 empresas industriales del PGP …
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Perfiles de empresas exportadoras. El caso de Mar del Plata
… industriales del Partido de General Pueyrredon (PGP) en relación a su comportamiento exportador, con el fin último de contribuir al conocimiento del fenómeno de la exportación en el nivel microeconómico, a partir de la evidencia de empresas industriales del PGP. La investigación es de tipo …
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Análisis de diversificación productiva intersectorial y a nivel de la firma
… la industria del Partido de General Pueyrredon (PGP), detectando factores determinantes de la misma: sectoriales y específicos a la empresa. Para ello se utilizan datos primarios, correspondientes a un total de 311 empresas industriales relevadas durante el segundo semestre de 2013. El diseño es …
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In vitro screening of crude extracts and pure metabolites obtained from marine invertebrates for the treatment of breast cancer
… the multidrug-resistant and P-glycoprotein (Pgp)-positive breast tumorcell lines MCF-7 Adr and MDA-A1r; and normal and malignant human breast epithelial cells (HBEC) in primary culture. Eight samples exhibited significant [drug concentration resulting in a 50% decrease in cell growth as …
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Characterization of Cre Mouse Models to Target CNS Barriers for Generating Conditional Knockouts of ABC Transporters
… ABC transporters, including P-glycoprotein (Pgp) and breast cancer resistance protein (BCRP), which are known to contribute to efflux of endogenous toxins and therapeutics from the CNS. Pgp and BCRP expression and activity are a crucial determinant of drug efficacy in the CNS and have been …
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Prognostic factors in soft tissue sarcoma. Tissue microarray for immunostaining, the importance of whole-tumor sections and time-dependence.
… p53, cyclin A, bcl-2, ß-catenin, CD44, and Pgp) in 218 malignant fi brous histiocytomas (MFH) and in 140 mixed STS. In the MFH series, tumor size and Ki-67, as the only IHC marker, provided independent prognostic information. In the mixed STS series whole-tumor sections were used and TMA was …
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A feasibility study of chemosensitivity testing in primary cultures from malignant gliomas, and analysis of drug resistance mechanisms
… data and immunohistochemistry for pglycoprotein (PGP), multiple drug resistance associated protein 1(MRP1), p53, Ki-67 and MGMT proteins. These profiles did not show any correlation between the factors analyzed and chemosensitivity to the five chemotherapeutic agents used. Functional studies of …
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