Global ETD Search
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Showing 1 to 15 of 15 for “"Pgd2"”.
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Comparison of human and mouse AKR1C enzymes: implications for modeling human cancer
… as a novel therapeutic target since its PGD2 reductase activity prevents cell differentiation. Mice are ideal organisms for in vivo studies, using knock-out or over-expression strains. However, no mouse models for AKR1C enzymes have been generated to date since the functional conservation …
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GENETIC AND QUANTITATIVE VARIATION IN WILD SOYBEAN (GLYCINE SOJA) POPULATIONS
… 0.044.</p><p>Four enzyme loci, Ap, Ti, Lap1 and Pgd2, belong to Linkage Group 9 of soybeans. The gene order of the four loci is Ap-Ti-Lap1-Pgd2, and the recombination frequency between each pair of loci Ap-Ti is 9.41% (+OR-) 1.07%, Ap-Lap1 22.65% (+OR-) 0.73%, Ap-Pgd2 39.78% (+OR-) 0.98%, Ti-Lap1 …
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The Efficacy Of Prostaglandin Synthase Inhibition On Attenuating Pressure Overload Induced Cardiac Remodeling
… pathways associated with prostaglandin D2 (PGD2) mediated fibrotic response. At the 14 day period, pressure overloaded animals shosignificant changes in LV structural and functional parameters. Cyclooxygenase-2 (COX-2) inhibition with Nimesulide significantly attenuated the structural and …
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Neuroimmune Interactions of Enteric Neurons and Mast Cells: Friends or Foes?
… activated receptor 2 (PAR2), prostaglandin D2 (PGD2) and interleukin 6 (IL-6). Immunocytochemical examination of rat small and large intestine, revealed frequent co-localization of corticotropin releasing peptide (CRF), known to induce psychological stress reactions in mammals, and vasoactive …
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Expression von pro- und antiinflammatorischen Zytokinen in Kupfferzellen der Rattenleber unter Normal- und Entzündungsbedingungen
… dieser Mediatoren (TNFα, IL-6, IL-1β, IL-10 und PGD2) in KC unter Normalbedingungen [d.h. KC aus unbehandelten Kontrollratten] mit der Expression unter Entzündungsbedingungen [d.h. längerfristige LPS-Behandlung in vivo ( LPS-Ratten ) oder in vitro oder in vivo und in vitro] verglichen. Die …
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Regulation of Astrocyte Functions by a Parkinson's Disease Gene, DJ-1
… RNAs (siRNA) 24 18. Prostaglandin D2 (PGD2) ELISA . 25 19. Inhibition of protein synthesis by cycloheximide 25 20. Inhibition of Ubiquitination by MG132 25 21. Measurement of nitric oxide 25 22. Statistical analysis . 26 III. RESULTS 27 Part A. DJ-1, (PARK7), plays critical roles in …
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In Vitro Studies of the Anti-Leukaemic Activity of Bezafibrate and Medroxyprogesterone Acetate Against Chronic Lymphocytic Leukaemia
… MPA induced the production of prostaglandin D2 (PGD2) and exogenously applied PGD2 was found to exert apoptosis in a similar manner to BEZ. Both BEZ and MPA generated reactive oxygen species (ROS) in both culture settings and the combination was more effective than either drug alone. In the …
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Intracellular signalling by arachidonic acid metabolites
… of pregnancy and parturition. The rise in PGD2 detected in the amniotic fluid before labour prompted the research presented in this thesis which describes the effects of 15-deoxy Δ12,14 -prostaglandin J2 (15d-PGJ2), a non-enzymatic metabolite of PGD2, on amnion-derived WISH and JEG3 …
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Role of Endogenous Prostaglandins on Kainic Acid Induced Seizure Activity
… administered PGF2α (700 ng), but not PGD2 (700 ng) and PGE2 (700 ng) completely alleviated KA-induced seizure activity potentiated by COX-2 inhibitors. PGF2α alone did not change the behavior on KA-induced seizure, however a FP receptor antagonist, AL 8810 (10 ng or 50 ng), an …
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The influence of the hormonal milieu on eicosanoid and cytokine production in tissues from the female reproductive tract.
In the human uterus prostaglandins (PG) PGE2, PGD2, PGI2, PGF2¿ and Thromboxane A2 (TXA2), also termed prostanoids, are synthesised and deactivated to 15-keto PGE2, J2 metabolites, 6-keto-PGF1¿, 15-keto PGF2¿ and TXB2 respectively. However, not all metabolites have been analysed simultaneously …
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Augmenting Anti-Tumor Immunity by Targeting Macrophage Cox-2 in Breast Cancer
… COX-2 inhibitor, marked suppression of PGD2 and PGE2 generation was evident in lipopolysaccharide (LPS)-stimulated J774A.1 cells. Importantly, urinary prostaglandin levels were not altered in mice treated with rHDL-celecoxib, suggesting no systemic inhibition of COX-2 with this targeted …
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The effect of eicosapentaenoic acid on brain and platelet produced bioactive lipid mediators. The effect of eicosapentaenoic acid, docosapentaenoic acid and other polyunsaturated fatty acids on the eicosanoids and endocannabinoids produced by rat brain and human platelets using electrospray ionisation tandem mass spectrometry-based analysis.
… although it is associated with an unpleasant PGD2 mediated skin flush. This exploratory study has shown that human platelets treated with niacin did not show any changes in their prostanoid and hydroxy fatty acid profiles. Platelets treated with EPA showed increased production of TXB3 and …
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Targeting pro-inflammatory mediators to treat visceral pain
… derived cytokines (TNFα & IL-4), lipids (PGD2 & LTC4) and growth factors (NGF & SCF) all increased [Ca2+]i in distinct populations of DRG neurons, the majority of which also responded to the TRPV1 agonist capsaicin, thus indicating that these neurons were nociceptors. TNFα levels correlate …
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An examination of the bioactive lipids involved in skin cell inflammation and in response to ultraviolet radiation. Effect of n-3 polyunsaturated fatty acid supplementation on red blood cell and human dermal fatty acid and production of eicosanoids by HaCaT keratinocytes and 46BR.1N fibroblasts following exposure to UVR.
… (PG) compared to HaCaT keratinocytes: PGE2 and PGD2 were the main PG in both HaCaT (7.96±3.18 and 1.48±1.19 pg/million cell; respectively) and 46BR.1N with (44.2±23.00 and 17.1±9.71 pg/million cell; respectively). Significant increase in PGE1 and PGE2 occurred when cells were exposed to 15mJ/cm2 …
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EVALUATION OF THE OXIDATIVE METABOLITES OF ARACHIDONIC ACID AND THEIR IMPLICATION IN THE PROGRESSION OF INFLAMMATORY DISEASES: HYPERTENSION AND RHEUMATOID ARTHRITIS
… involved separating urinary 8-iso PGF2, PGE2, PGD2, PGF2, 6-keto PGF1&alpha and 11-dehydro TXB2 on a SymmetryShield Rp18 column (250mm ¡Á 4.6mm) by an isocratic elution of 17 mM phosphoric acid and acetonitrile in the ratio of 65:35 and at a flow rate of 1.3 ml/min. The wavelength used for …