Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Pgc-1β"”.
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Mechanisms of ventricular arrhythmogenesis in the age dependent Pgc-1β -/- model of mitochondrial dysfunction.
… needed to dissect them. In this study, we use Pgc-1β-/- mice as a murine model of mitochondrial dysfunction, to further investigate the link between mitochondrial and energetic insufficiency and arrhythmias. The study uses electrocardiographic data to characterise the phenotype at the whole …
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Atrial arrhythmogenesis in a murine model of mitochondrial insufficiency
… receptor γ coactivator-1 β (Pgc-1β-/-). Pgc-1β regulates mitochondrial biogenesis and function, and unlike other murine models of mitochondrial dysfunction Pgc-1β-/- mice have a mild cardiac phenotype, devoid of confounding contractile dysfunction. All experiments were …
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Investigating the functions of PGC-1 isoforms in retinal pigment epithelia metabolism and their implications on age-related macular degeneration
… damage. The transcriptional co-activators, PGC-1α and PGC-1β, are important regulators of mitochondrial biogenesis and anti-oxidant capacity. Our group has previously shown that the PGC-1α protein promotes RPE oxidative metabolism and that overexpression of the PGC-1α gene protects cells …
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Regulation of Metabolic Processes by Micrornas and Class I Histone Deacetylases
… show that the Ppargc1b gene, which encodes the PGC-1β protein, also co-transcribes two microRNAs, miR-378 and miR-378*. Mice lacking miR-378/378* are resistant to high fat diet-induced obesity and display enhanced mitochondrial fatty acid metabolism and elevated oxidative capacity of …
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Insulin-like growth factor 1 effects on mitochondrial dynamics and mitophagy in cancer
… Receptor-γ (PPAR-γ) Coactivator-1 β (PGC-1β) and PGC-1-Related Coactivator (PRC) to promote mitochondrial biogenesis, while also inducing the mitophagy receptor B-cell Lymphoma 2 (BCL-2)/Adenovirus E1B 19 kDa Protein-Interacting Protein 3 (BNIP3). IGF-1 also activated the …