Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 3 of 3 for “"PfHsp40"”.
-
Characterization of Plasmodium falciparum PFF1010c and screening of pyrimidine-quinoline hybrids as inhibitors of HsP70-HsP40 functional partnerships of the Malaria parasite
… and is also implicated in protein trafficking. PfHsp40 (PF3D7_1437900.1) is a type I Hsp40 co-chaperone of PfHsp70-1 that presents substrates to PfHsp70-1 and stimulates its ATPase activity, while PFF1010c (PF3D7_0620700.1) is a type IV Hsp40 found in the gametocytes that is yet to be …
-
Elucidation of the role of the linker motifs of Plasmodium falciparum Hsp70-1 and Hsp70-z
… also reduced the affinity of PfHsp70-1 for PfHsp40. This possibly accounted for the lack of PfHsp40-induced stimulation of ATPase activity in the PfHsp70-1 linker mutant. Moreover, there was a marked reduction in the refolding efficiency of PfHsp701 and PfHsp70-z linker mutants, …
-
Comparative analysis of a chimeric Hsp70 of E. coli and Plasmodium falciparum origin relative to its wild type forms
Sustaining proteostasis is essential for the survival of the cell and altered protein regulation leads to many cellular pathologies. Heat shock proteins (Hsps) are involved in the regulation of the protein quality control. Hsps are a group of molecular chaperones that are upregulated in response to …