Global ETD Search
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Showing 1 to 4 of 4 for “"PfHop"”.
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Characterisation of the plasmodium falciparum HSP70-HSP90 organising protein
… Although a Hop homologue in P. falciparum (PfHop; PF3D7_1434300) is represented on the parasite genome, it is yet to be characterised. The objective of the study was to characterise the role of PfHop in mediating the functional partnership between PfHsp70-1 and PfHsp90. Structural domains …
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Identification of small molecule inhibitors targeting Plasmodium falciparum Hsp70-Hop pathway
… of the two chaperones. P. falciparum Hop (PfHop; PF3D7_1434300) brings together PfHsp70-1 and PfHsp90 into a functional complex. PfHop interacts with PfHsp70-1 (PF3D7_0818900) and PfHsp90 (PF3D7_0708400) through its tetracopeptide repeats (TPR) domains. PfHsp70-1 and PfHsp90 possess …
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Investigation of the role of the GGMP motif of Plasmodium falciparum Hsp70-1 on the chaperone function of the protein and its interaction with a co-chaperone, PfHop
… P. falciparum Hsp70/Hsp90 organizing protein (PfHop) constitutes one of the functional regulators of PfHsp70-1. PfHop allows PfHsp70-1 and its chaperone partner, PfHsp90 to form a functional partnership. Given the proximity of the GGMP repeats to the C-terminus of PfHsp70-1, it was postulated …
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Characterization of PFF1010c, a type IV Plasmodium fasciparum heat shock protein 40
… based tool. The expression of PfHsp90, PfHop and PfHsp70-1 at the gametocyte stage was investigated and confirmed by Western blot analyses.