Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 4 of 4 for “"Peutz-Jeghers Syndrome"”.
-
Structure of the LKB1-STRAD-MO25 tumour suppressor complex
… link between mutations of the LKB1 gene and the Peutz-Jeghers cancer syndrome. Since then, much effort has been devoted to understanding the functional roles of the protein encoded by the LKB1 gene. LKB1 is a Ser/Thr kinase that is activated by binding to the pseudokinase STRAD and the …
-
Targeting the intestinal stem cell niche through energy and metabolism signaling, for colorectal cancer chemoprevention using aspirin and metformin
… familial adenomatous polyposis (FAP), and Peutz- Jeghers syndrome (PJS). Upon treatment with aspirin and metformin, LGR5 and CMYC transcript levels were reduced in all normal mucosa patient-derived organoids. Aspirin and metformin attenuated the effects of lipid mixture overnutrition in …
-
Understanding The Role of Sumoylation In Regulating Lkb1 Function
… as a tumor suppressor mutated in patients with Peutz-Jeghers syndrome. Germline mutations in LKB1 predispose patients to develop several benign and malignant tumors including gastrointestinal and lung cancers. In 2003, several groups demonstrated that LKB1is a major upstream kinase of the energy …
-
The Role of LKBI Tumor Suppressor in Endometrial Cancer
… based on the tumor spectrum observed in Peutz Jegher women, many tumor suppressors have been found to have a much broader role in cancer than would have been predicted on the tumor spectrum associated with the hereditary syndrome. The studies that comprise this dissertation work first …