Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 41 for “"Personalised medicine"”.
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Personalised Medicine for Non-Alcoholic Fatty Liver Disease
Non-Alcoholic Fatty Liver Disease (NAFLD) is a chronic and dangerous condition which has grown in prevalence over recent decades due to increasing rates of obesity, affecting roughly a quarter of adults globally. This thesis develops a useable NAFLD definition which can be applied to large …
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Pharmacogenetics of African populations : variation in major drug metabolising enzyme genes and potential impact on personalised medicine.
Includes bibliographical references (leaves 167-200)
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Epigenetic and geometrical characterisation of cancer cell populations: A personalised-medicine oriented mathematical study of tumour evolutionary dynamics and therapies
L'abstract è presente nell'allegato / the abstract is in the attachment
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The Impact of Genetic Testing in Women with a Diagnosis and Family History of Breast Cancer: A Qualitative Investigation of Patient Experience
Personalised Medicine has the potential to impact cancer prevention, diagnosis, treatment and prognosis. Today efficient, affordable and available early BRCA1/2 screening techniques are now feasible and can provide results to inform treatment. However BRCA1/2 testing, undertaken close to cancer …
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Structural Limitations of Data Protection Legislation for the Learning Health System: Proposing a Lex Specialis for Longitudinal Biomedical Data Use
… health surveillance, biomedical research, and personalised medicine. These difficulties are accentuated in transnational and intersectoral efforts, due to the heightened legal compliance challenges that arise from the simultaneous application of multiple laws. To alleviate these difficulties, a …
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Survival of breast cancer patients and the potential for better prognostication
… are not individualised. Molecular platforms for personalised medicine has since evolved and perhaps will provide better prognostication. In this thesis, we study the ethnic difference in survival between an Asian and a Western population: Singapore and Stockholm; survival between different ethnic …
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Chemotherapeutic drugs, 5-fluorouracil and cisplatin, differentially affect exprssion of drug metabolising enzyme genes in an oesophageal cancer cell line
… of DMEs is crucial for the advancement of personalised medicine. The aim of this study was to determine the effects of two commonly-used chemotherapeutic drugs, as well as a CYP-inducing compound, on the differential expression of four pharmacogenetically relevant DME-encoding genes, …
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Imaging Myelin Basic Protein expression in a model of remyelination by Magnetic Resonance Imaging using an Organic Anion Transporter Protein gene reporter system.
… technique for use in drug discovery, or even personalised medicine.
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Advanced Bioelectronic and Microphysiological Systems for Functional Studies of Stem Cell-Derived Neural Models
… for disease modelling, drug screening, and personalised medicine.
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Exploring the potential application of glucuronides as a prognostic biomarker for disease.
… date indicates that genotyping can be useful for personalised medicine before administering a drug, the information is used to inform the patient which drug can be or cannot be used for treatment. This is to prevent adverse toxicological reactions during treatment of a disease. Therefore, …
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Electrokinetic phenomena in nanopore transport
… implications range from lab-on-a-chip devices to personalised medicine.
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Molecular Mechanism of MDA5 RNA Sensing in Innate Immunity and Disease Pathogenesis
… development of novel therapeutics and enhance personalised medicine approaches.
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Functional effects of cytochrome P450 variants on drug metabolism and adverse drug reactions: developing and extending high throughput P450 protein technology platforms
… studies is a step forward to the vision of personalised medicine. The enzyme family is known to be associated with the development of adverse drug reactions which are usually only discovered in late stages of drug development, therefore screening for potential adverse drug reactions earlier …
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Developing tailored approaches from multi-arm randomised trials with an application to blood donation
There is a growing interest in personalised medicine where individual heterogeneity is incorporated into decision-making and treatments are tailored to individual patients or patient subgroups in order to provide better healthcare. The National Health Service Blood and Transplant (NHSBT) in England …
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IMPACT OF INDUSTRY TRANSFORMATION ON THE LIFECYCLE OF PHARMACEUTICAL PRODUCTS: A Science and Risk Based Perspective
… evidence were: fully integrated pharma network, personalised medicine, translational research, and pervasive computing.Operational evidence to verify existence of the transformation triggers was compiled through systematic collection of operational data. Trends in the operational evidence and the …
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The application of genomic technologies to cancer and companion diagnostics.
… its molecular pathology. Molecular pathology and personalised medicine are being driven by discoveries in genomics, and genomics is being driven by the development of faster, better and cheaper genome sequencing. The next decade is likely to see significant changes in the way cancer is managed for …
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Focused CRISPR-Cas9 screens investigating the DNA damage response
… These results highlight opportunities for personalised medicine in cancer treatments including potential combinations of kinase inhibitors with more traditional therapeutic DNA damaging agents. In addition, we address key issues in optimal CRISPR-Cas9 screen design, in particular the effect …
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Metabolically rewiring pancreatic stromal cells in pancreatic cancer
… approach. Our data supports the concept of personalised medicine in which a patient will be treated based on their tumour’s genetic/metabolic profile, overcoming the current ‘one-drug-fits-all’ approach. Importantly, our findings could be translated to other hard to treat solid tumours.
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The Prospects of Personalising Medicine
Personalised Medicine (PM) is touted as a medical revolution where medical treatment and diagnosis is tailored to the individual patient so that it is optimal, safe, and exactly appropriate. Each chapter in this dissertation deals with the conceptual, methodological, epistemic, or ethical issues of …
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Pharmacogenetics : ethics and public policy
… way different individuals react to a particular medicine. Although for more than 5 decades, different studies have put forward quite a number of examples of direct associations between genotypes and drug response, it was only recently that pharmacogenetics has been introduced as a new paradigm …
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