Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Persister cells"”.
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Electrochemical Control of Bacterial Persister Cells
… percentage of phenotypic variants, known as persister cells, which are metabolically inactive and extremely tolerant to antibiotics. When the antibiotic treatment is stopped, surviving persister cells can regenerate the bacterial population with a similar percentage of persister cells. Thus, …
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CONTROLLING BIOFILM AND PERSISTER CELLS BY TARGETING CELL MEMBRANES
… of intrinsic mechanisms of drug resistance is persister formation, by which bacterial cells enter a metabolically inactive stage and become highly tolerant to essentially all antibiotics, even at the concentrations that are hundreds of times higher than the lethal dose required to kill normal …
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Controlling Bacterial Persister Cells and Biofilms by Synthetic Brominated Furanones
… biofilms, and by entering dormancy and forming persister cells. Both mechanisms allow bacteria to tolerate antibiotics at concentrations hundreds to thousands of times higher than the lethal dose for regular planktonic cells of the same genotype. Persister formation increases in biofilms; thus, …
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Controlling Pseudomonas aeruginosa Persister Cells by Human Granulocyte Macrophage Colony-Stimulating Factor
… During bacterial invasions, the host immune cells secrete special signaling proteins, known as cytokines which orchestrate events leading to human immune response and elimination of bacterial pathogens. However, compared to the well documented activities</p> <p>of cytokines in immune …
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The Emergence of Diverse Drug-Resistance Mechanisms from Drug Tolerant Cancer Persister Cells
… on eliminating fast-growing populations of cells, yet a growing body of evidence suggests that small subpopulations of cancer cells can evade strong selective drug pressure by entering a slow-growing "persister" state. This drug-tolerant state has been hypothesized to be part of an initial …
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Transient Metabolic Alterations Induced by Chemotherapeutics in Cancer Persisters
… has revealed the existence of slow-cycling persister cells that survive drug treatments and give rise to multi-drug tolerant mutants in cancer. The mechanisms associated with persister phenotypes are highly diverse and complex, and many aspects of persister cell physiology remain to be …
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Computational Systems Biology Analysis of Cell Reprogramming and Activation Dynamics
… of bacteria E.coli between normally-growing cells and persister cells (growth-arrested phenotype), and how this process can contribute to drug resistance. We built up a complex computational model capturing the molecular mechanism on both single cell level and population level. The paper also …
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Population dynamics of bacterial persistence
… of population in a drug tolerant state, the persister state. Specifically, persister cells grow more slowly than normal cells under growth conditions, but survive longer under stress conditions such as the antibiotic administrations. Bacterial persistence is identified experimentally by …
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The microbiology of diabetic foot infections: a Ghanaian perspective
… resistance genes and/or the presence of persister cells that are unresponsive to antimicrobial agents. The work presented here studied the role of 2 multidrug resistant DFU isolates, Klebsiella pneumoniae and Proteus mirabilis in maintaining the chronicity of diabetic foot ulcers. Using 3 …
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Exploiting tumour cell dependency on pro-survival BCL2 proteins with BH3 mimetics
… In this thesis, we determined that melanoma cells had a high MCL1:BCL-XL ratio, and as a result were biased towards MCL1 due to low expression of BCL-XL. Consequently, melanoma cells were uniquely dependent on MCL1 to restrain the pro-apoptotic BH3-only proteins induced by ERK1/2 pathway …