Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 58 for “"Persistent Infection"”.
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Immunomodulation by subclinical persistent infection with Helicobacter hepaticus
Recognition of polymicrobial infections is becoming important for understanding differential host responses to environmental exposures, vaccines, as well as therapeutics. Citrobacter rodentium is a well-characterized model of infectious colitis with particular usefulness for modeling human …
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Characterization of Avirulent Turkey Hemorrhagic Enteritis Virus: A Study of the Molecular Basis for Variation in Virulence and the Occurrence of Persistent Infection
… in various tissues through 15 weeks post-infection in the presence of high antibody titers. THEV infection was found to be similar to the non-lytic persistent infections seen with human adenoviruses. Regardless of the mechanism involved in the persistent stimulation of antibodies in …
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Maintaining the balance: persistent baculovirus infection in insect cells
… kill the host. However, many species harbour persistent, non-lethal covert baculovirus infections although these have rarely been observed in vitro. Hence, little is known about the mechanisms for establishment or maintenance of persistent infections. Re-infection with a homologous baculovirus …
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Standards of Care and Practice to Reduce Catheter-Associated Urinary Tract Infections
… number of day’s catheters remain inserted, the persistent infection rates demonstrate the need for continued improvements in hospital processes and nursing practices related to urinary catheters. </p>
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Identification of Viral Determinants of Murine Norovirus Pathogenesis
… the only member of this genus that establishes infection in a small animal model, can be grown in cell culture, and has a reverse genetics system. Noroviruses are divided into genogroups which can contain many viral strains. These viral strains can display dramatic variation in their virulence …
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Staphylococcus aureus small colony variants use heme and staphyloferrin B for iron acquisition
… variants (SCVs) are associated with chronic infections, yet the mechanisms by which these variants acquire iron are unknown. Mutation of hemB, involved in heme biosynthesis, generated a stable SCV that was auxotrophic for hemin and formed small colonies on solid media. To support growth under …
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The Role of the Mismatch DNA Repair Protein MutL in Antigenic Variation of the Lyme Disease Spirochete
… employed by Borrelia burgdorferi to establish a persistent infection in the host through changes of its outer membrane lipoprotein, VlsE, by recombinational events at the vls locus. A recent study identified a requirement for the endonuclease activity of MutL, a canonical DNA mismatch repair …
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LONG-COVID AND COGNITION
… who do not recover from their initial infection, making them long haulers. Long-COVID is transitioning from a range of isolated phenomena to higher prevalence rates in patients who contracted COVID-19. Many individuals report issues with cognitive function, referred to as ‘brain fog’, …
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Reactivation of persistant tuberculosis
… in clinical disease. Using low dose aerosol infection of M. tuberculosis in mice, a short-duration model of rifampicin-isoniazid (RMP-INH)-induced persistent tuberculosis is described. This persistent infection is characterised by undetectable levels of colony-forming units (CFU) in mouse …
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Developing improved challenge viruses for macaque models of HIV-1 infection
Infection of macaques with SIV/HIV chimeric viruses (SHIVs) is often used as a model of HIV-1 infection for pre-clinical vaccine studies. Although SHIV infection of macaques serves as the gatekeeper of promising vaccine candidates, it is limited by the fact there are a very small number of SHIVs …
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Maternal Chlamydia trachomatis and Neisseria gonorrhoeae Infections and the Outcome of Preterm Birth: The Impact of Early Detection
… condition. Maternal genitourinary tract infection may reduce the length of gestation through premature rupture of membranes and/or preterm labor. Specifically, antenatal infection with Chlamydia trachomatis and/or Neisseria gonorrhoeae, both high prevalence sexually-transmitted …
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Prevalence of bovine viral diarrhea virus subspecies among persistently infected positive samples submitted to a diagnostic laboratory from cattle in the United States
… (ear notch) had previously tested positive for persistent infection via antigen capture ELISA (ACE) or immunohistochemistry (IHC). This study was comprised of 1,093 samples from 21 states, with a majority of samples from Kansas, Kentucky, Oklahoma, and Texas. Positive samples were submitted to a …
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pH Stability of Calcium Hydroxide Preparations in a Simulated Acidic Environment
… for challenging clinical scenarios involving persistent infection or acidic environments. The findings support the integration of bioceramic technology into calcium hydroxide formulations for improved performance.
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Effect of Human Immunodeficiency Virus Infection on Human Papillomavirus Clearance among Women in Senegal, West Africa
Background. Persistent infection with human papillomavirus (HPV) is associated with development of cervical-related disease. Methods. A total of 174 Senegalese women completed health questionnaires and were tested for Human Immunodeficiency Virus (HIV) upon enrollment, as well as were tested HPV at …
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The role of the P28 multigene family in the pathogenesis of Ehrlichia chaffeensis infection.
… but is maintained in the environment by persistent infection of animal hosts. <i>E. chaffeensis</i> causes the emerging infectious disease, human monocytic ehrlichiosis (HME), a potentially fatal illness. Although easily treated with tetracycline, due to its obligate intracellular …
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Identification and characterization of cell-adapted mutations in West Nile Virus and replicons
… some of the factors that contribute to a persistent West Nile virus (WNV) infection, WNV subgenomic replicon (WNR) genomes were modified to contain neomycin phosphotransferase (antibiotic-resistance) gene and cells that persistently harbored this WNR were selected for using G418. There …
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Pyrimidine Enzyme Specific Activity at Four Different Phases of Growth in Minimal and Rich Media, and Concomitant Virulence Factors Evaluation in Pseudomonas aeruginosa
… and nutritionally versatile bacterium. Infections by P. aeruginosa are the most important cause of morbidity and mortality in immunocompromised patients, given virulence factor production that suppresses antibiotic therapy and promotes persistent infection. This research is the first …
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Elucidation of antigenic epitopes on the rubella virus E1 glycoprotein
… and arthritis following vaccination or infection are common and rare cases of progressive panencephalitis have been reported. To obtain a better understanding of the immunopathology of RV infection, the degree of antigenicity of the structural proteins in humans were examined for both …
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A guinea pig model of human respiratory syncytial virus lung infection
… and airway inflammation. Because latent or persistent pulmonary viral infections have been implicated in the pathogenesis of the airway inflammation underlying asthma, a guinea pig model of human RSV lung infection was developed to test the hypothesis that RSV persists within the lung …
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Control of Inflammation Using Drug Delivery Strategies in in vitro Models
… of the immune system in response to injury and infection. In otherwise healthy individuals, an initial acute inflammatory response will subside once the injury or infection is eradicated. However, in certain disease states including autoimmune disease and persistent infection, miscommunication …
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