Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Peroxisome proliferator-activated receptors"”.
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Role of peroxisome proliferator-activated receptors in mechanisms of rejection in heart transplantation
Peroxisome proliferator-activated receptors (PPARs) belong to a nuclear receptor superfamily; two major isoforms, PPARα and PPAR[gamma], are primarily involved in lipid and glucose homeostasis. However, evidence also suggests roles for PPARs in regulating inflammation and atherosclerosis, and …
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A Study on the Effect of Peroxisome Proliferator-Activated Receptors (PPARs) Activation in Cultured Rat Brain Glial Cells
"The peroxisome proliferator-activated receptors (PPARs) are nuclear receptors, which were originally known to be involved in the regulation of lipid and glucose homeostasis. Recently, there has been increasing reports on the involvement of PPARs during inflammatory process, but the exact …
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Lipotoxicity in smooth muscle
… significant differences in the levels of certain peroxisome proliferator-activated receptors (PPARs) between Yucatan and Ossabaw male swine and between male and female Ossabaw swine, suggesting genetic and gender differences in PPARs. These results may explain the differences in prevalence of …
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Integration of Genome Scale Data for Identifying New Biomarkers in Colon Cancer: Integrated Analysis of Transcriptomics and Epigenomics Data from High Throughput Technologies in Order to Identifying New Biomarkers Genes for Personalised Targeted Therapies for Patients Suffering from Colon Cancer
… such as immune-response, lipid metabolism and peroxisome proliferator-activated receptors (PPARs) signalling pathways. For the first time, we also identify miRNAs that can differentiate between primary colon from metastatic and a prognostic signature of grade and stage levels, which can be a …
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The Effects of PPAR-γ Activators on the Growth and Apoptosis of Melanocytes
PURPOSE: Peroxisome proliferator-activated receptors (PPARs) play an important role in cellular responses including proliferation and differentiation. It was reported that 3 subtypes of PPAR are expressed in human melanocytes and activators for PPAR-α and PPAR-γ modulates melanocyte growth and …
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Defining the metabolic effect of peroxisome proliferator-activated receptor δ activation
Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors that function as ligand activated transcription factors. There are three identified isotypes: PPAR alpha, PPAR gamma and PPAR delta, together controlling the expression of genes involved in inflammation, cell differentiation, …
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Molecular Mechanisms Governing the Pharmacology of LDT409 for the Treatment of Metabolic Disease
… safe medications to treat these diseases. The peroxisome proliferator-activated receptors (PPARa/g/b) are fatty acid sensors that play important roles in the regulation of lipid metabolism and glucose homeostasis. Herein, we report the characterization of novel compounds derived from phenolic …
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Biological and Chemical Investigation of Panamanian Plants for Potential Utility against Metabolic Syndrome
… study was centered on four molecular targets: peroxisome proliferator-activated receptors (PPARs), liver X receptors (LXRs), nuclear factor-κB (NF-κB), and inducible nitric oxide synthase (iNOS) which are key regulators of various processes leading to metabolic disorder and inflammation. As a …
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Exploring the molecular basis to the regulatory effects of Cannabinoids on toll-like receptor signalling
… and NFκB are independent of the cannabinoid receptors and evidenced is presented suggesting a potential role for peroxisome proliferator activated receptors in mediating the regulatory effects R(+)WIN55,212-2. Overall these findings highlight that R(+)WIN55,212-2, by targeting IRF3 and IFN- …
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Metabolic Regulation by Fibroblast Growth Factor 21
… expression is transcriptionally regulated by the peroxisome proliferator activated-receptor alpha (PPARa) in liver. PPARa is a member of the nuclear hormone receptor superfamily that is physiologically activated by increased fatty acid mobilization to liver during fasting, and regulates the …
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Caratterizzazione del clofibrato agonista sintetico dei recettori dei proliferatori dei perossisomi (PPARα)in modelli animali di depressione ed ansia
… for the pharmacotherapy of depression. Peroxisome proliferator-activated receptors alpha (PPARα) are widely expressed in the brain and are activated by endogenous ligands like the fatty acid amides N-palmitoylethanolamide (PEA) and oleoylethanolamide (OEA). Recent studies have been …
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Leptin and peroxisome proliferator activated receptor alpha: understanding their contribution towards normalising the programmed phenotype in the peripheral tissues of IUGR offspring
… of adult offspring. These genes included the peroxisome proliferator activated receptors (PPARs) and their target genes; acyl-coA oxidase (AOX), carnitine palmitoyl transferase-1 (CPT-1) and lipoprotein lipase (LPL).<br/><br/>Real time PCR indicated that the expression of several key genes …