Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"Peroxisome Proliferator Activated Receptor Gamma"”.
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Characterizing the Binding Potential, Activity, and Bioaccessibility of Peroxisome Proliferator Activated Receptor Gamma (PPARγ) Ligands in Indoor Dust
… act via the activation (i.e. agonism) of the peroxisome proliferator activated receptor γ (PPARγ) nuclear receptor. To date, very few chemicals have been identified as possible PPAR ligands. In the thesis, our goal was to determine the PPARγ ligand binding potency and activation of several …
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Role of Extracellular Signal-Regulated Kinase and Peroxisome Proliferator-Activated Receptor gamma on Transforming Growth Factor-β1-Induced Human Endometrial Stromal Cell Decidualization
… To investigate the role of ERK and PPAR gamma on TGF-β1-induced human endometrial stromal cell decidualization in vitro. MATERIALS AND METHODS: Human endometrial tissues obtained by hysterectomy specimens from patients with conditions other than endometrial diseases such as leiomyoma. …
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Regulation of Pyruvate Dehydrogenase Kinase 4 by Thyroid Hormone / Role of Peroxisome Proliferator Activated Receptor Gamma Coactivator-1 alpha and Ccaat Enhancer Binding Protein
… I have examined the role of the thyroid hormone receptor (TR), transcriptional coactivators especially the peroxisome proliferator activated receptor gamma coactivator-1 (PGC-1α) and other transcription factors that act as accessory factors in T3 actions. </p> <p>Thyroid hormone receptors (TRα or …
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Analysis of lipid metabolism regulators in breast cancer cells after induction of the Epithelial to Mesenchymal Transition
… (EMT), a key developmental program that is often activated during cancer invasion and metastasis. During the EMT process, cells undergo phenotypic changes, lose of E-cadherin expression and acquire invasive properties that allow them to migrate through the extracellular matrix. EMT inducers or …
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Temporal examination of DNA methylation profile reprogramming in the promoter region of PGC-1α during the progression of insulin resistance and type 2 diabetes mellitus in rodent models
… of DNA methylation, in the promoter region of peroxisome proliferator activated receptor gamma coactivator 1 alpha (PGC-1α), a known regulator of mitochondrial biogenesis. Following the initiation of a high fat diet, we observed significant genotypic (DNA methylation) and phenotypic …
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Characterization of an in vitro exercise model and the effects of a metabolic endotoxemia on skeletal muscle adaptation to electric pulse stimulation
… of time and measured interleukin-6 (Il-6), peroxisome proliferator-activated receptor gamma coactivator 1- (PGC1-), superoxide dismutase 2 (SOD2), substrate metabolism, metabolic enzyme activity, heat stress markers, and pH. To recreate the inflammatory milieu observed in metabolic disease …
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Anticonvulsant effects of PPAR-gamma activation in an in vitro model of seizure
Peroxisome proliferator activated receptor gamma (PPARγ) is a ligand-modulated transcription factor belonging to the nuclear receptor superfamily. PPARγ regulates genes involved in adipocyte differentiation, insulin homeostasis, neuroprotection and anti-inflammation. As such, PPARγ is under …
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A Role for Microglia Activation in Modulating Behavior in a Variable Stress Model for Depression
… variable stress female microglia acquire a more activated phenotype compared to microglia in males. These sex specific effects in microglia activation were also observed in the nucleus accumbes, but not the dentate gyrus after 28 days of stress. Utilizing a number of pharmacological agents, we …
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Effects of dietary stimulators of metabolism and mitochondrial biogenesis in vitro and in vivo: Implications for metabolic disease
… by dietary stimulators of metabolism and peroxisome proliferator-activated receptor gamma co-activator 1 (PGC-1) in skeletal muscle. Our work uniquely describes the effects of a commercially available dietary supplement on resting metabolic rate in humans as well as the metabolic and …
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Refinement of the Docking Component of Virtual Screening for PPAR
Exploration of peroxisome proliferator-activated receptor-gamma (PPAR") as a drug target holds applications for treating a wide variety of chronic inflammation-related diseases. Type 2 diabetes (T2D), which is a metabolic disease influenced by chronic inflammation, is quickly reaching epidemic …
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Abscisic acid ameliorates glucose tolerance and obesity-induced inflammation
… (TZDs), which act through the nuclear receptor peroxisome proliferator-activated receptor gamma (PPARgamma ). Due to the many side-effects of TZDs, our laboratory sought out a natural phytochemical, abscisic acid (ABA), with chemical similarities to TZDs. Our first study demonstrated …
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PPARγ-pERK interaction restores memory consolidation in an Alzheimer’s disease model
… We and others have previously reported the peroxisome-proliferator activated receptor gamma (PPARγ) agonist rosiglitazone improves hippocampus-dependent cognitive deficits in some AD patients and ameliorates deficits in the Tg2576 mouse model for AD amyloidosis. Since extracellular …
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Genetic association between schizophrenia and type-2 diabetes
… polymorphisms (SNPs) in the genes coding for peroxisome proliferator activated receptor-gamma (PPARG), phospholipid A2, group IVA (PLA2G4A), prostaglandin-endoperoxide synthase 2 (PTGS2) and v-akt murine thymoma viral oncogene homolog 1 (AKT1). The Haploview™ program was applied to check …
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Cellular Reprogramming in Skeletal Muscle after Repeated Exposures to Endotoxin
… derangements have been linked to toll-like receptor 4 (TLR4), an innate immune system receptor, due to its role in proinflammatory pathways. Lipopolysaccharide (LPS), a gram-negative bacteria cell wall component, is the ligand for TLR4, and has been shown to be elevated in states of …
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Regulation of satellite cells by extrinsic factors during recovery from exercise in horses
… compared to controls while exercise increased peroxisome proliferator-activated receptor gamma coactivator 1- α (PGC1α) mRNA abundance, a master regulator of energy metabolism, at 1 d post-exercise. Although SCs were not activated in response to a single bout of submaximal exercise, metabolic …
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Neuroprotective and immunomodulatory properties of the new PPARγ agonist MDG548: an in vitro and in vivo study in PD models
… proposed as a target for neuroprotection. The peroxisome proliferator-activated receptor gamma (PPARγ) is expressed in microglia and peripheral immune cells, where it is involved in macrophages polarization and in the control of inflammatory responses, by modulating gene transcription. Several …
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Comparison of human and mouse AKR1C enzymes: implications for modeling human cancer
… of myogenesis was independent of PGD2 surface receptors DP1 and DP2 and activation of the peroxisome proliferator-activated receptor \(\gamma\) (PPAR\(\gamma\)) suggesting a new form of signaling is involved. This discovery has implications in the interplay between inflammation, where high …
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Microbiological, genomic and transcriptomic analyses of human tuberculosis lung cavities
… gene-1, and other pathogen-recognition receptors. However, genes encoding for eukaryotic initiation factor-2, triggering receptor expressed on myeloid cell-1 and peroxisome proliferator activated receptor gamma-signalling, amongst others, were upregulated. CONCLUSION: Heterogeneity in …
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Mechanisms underlying enhanced bone marrow adipogenesis in diabetes
… that TGFB1 utilizes the non-canonical TGFB-activated kinase 1 (TAK1)-mediated mechanism to inhibit adipogenesis. Transcriptome-wide gene expression profiling revealed a potential involvement of the Wnt pathway, confirming previous studies in our laboratory. Finally, I tested the effect of a …
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