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Showing 1 to 12 of 12 for “"Peroxiredoxins"”.
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Functional stability of plant peroxiredoxins
Peroxiredoxins (Prx), a ubiquitous superfamily of peroxidases, are an important component of the antioxidant network of the cell, with members of the subgroups of 2-Cys Prx and type II Prx being in focus of the present work. A comparative characterisation of cytosolic PrxII B and PrxII C was …
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STUDIES OF THE ELECTROSTATIC PROPERTIES OF PEROXIREDOXINS
Peroxiredoxins (Prxs) are peroxidases which can also regulate cell signaling pathways, apoptosis, and differentiation. During catalysis, Prxs exhibit cysteine-dependent reactivity which requires the deprotonation of a peroxidatic cysteine (Cp) via a lowered pKa in the initial step. Local …
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STRUCTURAL AND CATALYTIC FEATURES AFFECTING INACTIVATION OF TYPICAL 2-CYS HUMAN PEROXIREDOXINS 2 AND 3
… One such class of enzymes, human typical 2-cys peroxiredoxins, is involved in redox regulation through the cyclic oxidation and reduction of cysteine residues during its normal catalytic cycle. This redox cycling facilitates hydrogen peroxide (H2O2) based cell signaling, protects cells from …
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Molecular characterization of XvPer1, a novel antioxidant enzyme from the resurrection plant Xerophyta viscosa, and AC3, a LEA-like protein from Arabidopsis thaliana
… Mw of 24.2 kDa with high identity to plant l-Cys peroxiredoxins, a novel antioxidant enzyme. Southern blot analysis revealed that XvPer I was most probably a single copy gene. The polypeptide sequence had significant identities (-70%) with other recently identified plant I-Cys peroxiredoxins with …
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Studies in Peroxiredoxin Hyperoxidation Sensitivity
… focuses on the structure and biochemistry of peroxiredoxins (Prx) and their sensitivity to inactivation by their own substrate, in a process called hyperoxidation. Hyperoxidation sensitivity is important to study because Prxs are implicated in many different diseases. For example, Prxs …
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Characterization of cathepsin B cysteine protease from Naegleria fowleri excretory-secretory proteins exerting immunomodulatory effects
… (Nf-ESPs) include phospholipase, proteases, peroxiredoxins and thrombin receptor. However, the precise mechanism induced by Nf-ESPs in PAM is not fully understood yet. In this study, the cytopathic changes and inflammatory responses induced by Nf-ESPs were analyzed in BV2 microglial cells. …
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Expression of Prxiredoxin I, III and Thioredoxin in human lung cancer and the normal lung tissues
… new family of novel antioxidant proteins, peroxiredoxins (Prxs), have been implicated in regulating many cellular processes including cell proliferations, differentiation, and apoptosis. They are also reported to function as an oxidative stress-dependent molecular chaperone for many …
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Proteome Profiling of Saccharomyces cerevisae stress response to Cumene Hydroperoxide (CHP)
… including posttranslational modifications of peroxiredoxins. Redox active protein, Ahp1, was regulated post-translationally with sulfonic acid modification observed for its active Cys(62) residue.
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Xenobiotic metabolism and markers of genotoxicity in regulatory non-vertebrate ecotoxicological test species
… stressor (e.g. glutathione-S-transferases, peroxiredoxins, ferritins), and potential reproductive and population level effects were identified. In all this study has highlighted the potential use of C. reinhardtii and D. magna in genotoxicity testing, using the methods developed herein. …
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Induction of Anopheles stephensi nitric oxide synthase by Plasmodium-derived factor(s)
… increased expression levels of P. falciparum peroxiredoxins containing 1 or 2 cysteines (1-cys or 2-cys PfPrx) were associated with periods of parasite development just prior to and during parasite penetration of midgut epithelium, an event associated with significant AsNOS induction in the …
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<i>Plasmodium</i>-Induced Nitrosative Stress in <i>Anopheles stephensi</i>: The Cost of Host Defense
… induced to minimize self damage. I proposed that peroxiredoxins (Prx), enzymes that can detoxify peroxides and peroxynitrite, may protect <i>A. stephensi</i> from nitrosative stress. Six Prx genes were identified in the <i>A. gambiae</i> genome based on homology with known <i>D. melanogaster</i> …
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Involvement of the NMDA Receptor in Moderate Ethanol Preconditioning-Dependent Neuroprotection From Amyloid-Beta in Vitro
… et al., 2008). In exploring whether or not peroxiredoxins were increased in association with augmented NMDAR activity in the MEP model, initial evidence indicated that cytosolic peroxiredoxin-2 is increased by day 6, but not earlier--correlating with the appearance of statistically …