Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"Peritumoral"”.
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The Combined Effect of In-Situ Tumor and Irradiation on Peritumoral Brain Vasculature
… that tumor growth has an adverse effect on the peritumoral tissue through the angiogenic/inflammatory environment it creates rendering it susceptible to further damage by RT which may be prevented by using anti-angiogenic/anti-inflammatory agents. We have developed a rat C6 glioma brain tumor …
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Correlação da localização topográfica e do edema peritumoral em pacientes com glioma recidivo com a resposta terapêutica ao álcool perílico
… uma correlação da topografia tumoral e edema peritumoral com a resposta terapêutica à administração intranasal do álcool perílico (AP) em pacientes com glioblastoma (GBM) recidivo após tratamento convencional. Métodos: A coorte incluiu o estudo retrospectivo de 119 pacientes com glioma …
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Acidic Pericellular Ph: Effects On Proteolysis And Gene Expression As Determined In 3d Models Of Breast Carcinoma
… to malignancy of solid tumors is an acidic peritumoral pH. The first objective was to determine if an acidic extracellular pH observed in vivo (i.e., pHe 6.8) affects the activity of proteases, such as cathepsin B, that contribute to degradation of collagen IV by tumor cells when grown in …
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Neuronal and Electrophysiological Markers of Glioma
… and non-infiltrated zones within specifically peritumoral tissue (PT) and, more extensively, across the radiologically-defined boundaries of healthy, peritumoral and tumoral tissues. As such, we propose for the first time an objective demarcation and characterization of the PT and we detail how …
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Papel de los fibroblastos peritumorales en la progresión del cáncer de colon humano: desarrollo de un modelo animal
… a nivel mundial. Se ha visto que el estroma peritumoral juega un papel importante en este tipo de cáncer. En este estudio centramos nuestra atención en los fibroblastos peritumorales (CAFs), y el ColXIα1, que es un marcador específico de estas células. El objetivo de esta tesis es analizar la …
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Valor pronóstico de la expresión de las metaloproteinasas 1, 2, 7, 9, 11, 13, 14 y sus inhibidores tisulares 1, 2 y 3 en los fibroblastos del estroma peritumoral, estudiada mediante micromatices tisulares en piezas de prostatectomía radical
… su papel fundamental en la invasión del estroma peritumoral en diversos tumores, incluido el adenocarcinoma prostático. Basándonos en estos datos postulamos que la detección de la expresión de metaloproteinasas 1, 2, 7, 9, 13, 14 y de sus inhibidores tisulares 1, 2 y 3 en los fibroblastos del …
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Supramolecular Structure-Enabled Delivery of Porphyrin to Glioblastomas Beyond the Blood-Brain Barrier
… (4:1) tumor:healthy tissue uptake and effective peritumoral porphyrin fluorescence (at least 1 mm depth from visible tumor boundaries). The effective trans-BBB, targeted glioblastoma and peritumoral porphyrin delivery achieved by pyE-LN ± microbubble/FUS opens new avenues for more effective …
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MRI at 3 T of brain functions and fibre tracts adjacent to intracranial tumors
… and lesion-to-brain ratios of ADC and FA in peritumoral edema did not differ between high grade gliomas, meningiomas and metastases (Paper 4). Conclusions: Our results suggest that the spatial resolution of fMRI using a clinical protocol is adequate for localisation of the sensory …
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Quantitative Magnetic Resonance Imaging For The Early Prediction of Treatment Response In Triple Negative Breast Cancer
… <p>Third, diffusion MRI measurements in the peritumoral region were developed and applied as predictors of NAST response. We found that maximum diffusion and the standard deviation of diffusion in peritumoral regions including fatty tissues were useful for prediction of NAST response.</p> …
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Genetic and mechanistic determinants of prostate cancer progression and metastasis
… to lymph nodes is mediated primarily by peritumoral lymphatic vessels, which surround the tumor at the invasive margins. In contrast, inhibition of intratumoral lymphatics did not affect metastatic spread, indicating that these vessels were unnecessary for tumor cell dissemination.
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The Role of Adipocytes in the Tumor Microenvironment in Obesity-Driven Breast Cancer Progression
… of these models, we performed RNA sequencing of peritumoral mammary fat pads and uninvolved contralateral fat pads. Pathway analysis showed an upregulation in transcripts involved in polyamine and creatine biosynthesis in the obese tumor microenvironment. We have found that the rate limiting …
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Modulating System xc- Activity As A Treatment For Epilepsy
… seen in glioblastomas lead to higher levels of peritumoral glutamate, neuronal excitotoxicity, and ultimately seizures. These studies also found that SXC inhibition with sulfasalazine (SAS), an FDA approved drug and potent inhibitor of SXC, can ameliorate seizure burden in a glioblastoma mouse …
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Inmunolocalización de la sustancia P y del receptor NK-1R en el craneofaringioma adamantinomatoso
… significativa más expresada en la reacción glial peritumoral que en otras regiones del tumor y se localiza en la membrana de las células y en los núcleos de las células inflamatorias. Discusión: La necesidad de desarrollar tratamientos médicos efectivos y a la vez que minimicen la morbilidad …
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Modulation of System x<sub>c</sub>- Mediated Glutamate Release in Glioblastoma Multiforme via the Extracellular Matrix: The Agony and the Xctasy
… immediately surrounding the tumor, known as the peritumoral region, reach glutamate concentrations over 100 times that of the normal brain, creating an excitotoxic environment in which neurons cannot survive. In addition to neuronal excitotoxicity, excess glutamate release has also been shown to …
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Papel de los fibroblastos peritumorales en la progresión del cáncer de páncreas humano: estudio del gen erizo
… con nuevas medidas terapéuticas. El estroma peritumoral, en el cáncer de páncreas, no es solo un espectador, sino que juega un papel muy importante en la invasión y la progresión tumoral. Debido a esto, la tesis se basa en tres objetivos, analizar la influencia de los fibroblastos …
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T-Zell Gedächtnis und Zytokinmilieu bei Kopf-Hals-Tumoren
… Die CD8 T-Zellen konzentrierten sich peritumoral und drangen nicht tiefer ins Tumorinnere ein. Die Tumore wurden bei einer Th1 Tumorreaktivität von Lymphknoten T-Zellen gleichmäßig von CD4 und CD8 T-Zellen infiltriert. Letztere waren sowohl peri- als auch intratumoral nachweisbar. Die …
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Characterising Peritumoural Progression of Glioblastoma using Multimodal MRI
… MR technique to identify and characterize the peritumoral progression zone that eventually leads to tumor progression. Patients with newly diagnosed cerebral glioblastoma were included consecutively from our cohort between 2010 and2014. The presurgical MRI sequences included volumetric …
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Impact Of Cryoablation On Tumor Immunity
… excision, sham surgery, and/or 100 micrograms peritumoral (p.t.) CpG ODN. NeuT mice received vaccination with plasmid DNA encoding neu/Her2 and GM-CSF to induce an initial response. Specific IgG antibody (Ab) subclasses and T-cell responses were assessed using flow cytometry and IFN gamma …
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Glioma: A Tale of Corticosteroids, Thiopurines and Proposed Novel AntiGlioma Small Molecules
… Corticosteroids are mainstay drugs for managing peritumoral edema. Therefore, we investigated the effect of corticosteroids in a PDGF driven glioma mouse model. We found that corticosteroid treatment decreases tumor cell proliferation without inducing cell death as shown by a significant decrease …
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Efeito da inibição de Serine Arginine Protein Kinases (SRPKs) em modelo de melanoma murino subcutâneo
… Os dois últimos grupos foram tratados por via peritumoral, sendo o grupo controle o que recebeu 150 μl de DMSO 1% e o grupo tratado o que recebeu 150 μl de SRVIC30 diluído em DMSO 1%. O tratamento foi administrado cinco vezes por semana, no decorrer de 14 dias. Análises histológicas de tumor e …
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