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Showing 1 to 8 of 8 for “"Peripheral nerve repair"”.
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REPEATED BIPHASIC CONDUCTING CONDUITS FOR PERIPHERAL NERVE REPAIR
Each year 400,000 Americans sustain nerve transection injuries which require surgical intervention for repair. Due to rapid scar formation which blocks nerve outgrowth, there are no treatment options for the approximately 90% of patients who have gaps greater than 3 cm. Resultantly, researchers …
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Fabrication and evaluation of a collagen-based fiber-gel three-dimensional construct for peripheral nerve repair
Nerve regeneration following a peripheral nerve injury often relies on growth cone- mediated guidance and the presence of Schwann cells to support the regenerating axons and remyelinate portions of denervated nerve pathways. The emphasis of this work is to develop a synthetic nervous tissue …
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Molecular biology of peripheral nerve regeneration: Expression and role of Netrin-1, DCC and Runx2
Damage to the peripheral nerves causes a series of molecular, cellular, and structural changes critical to initiating a successful regenerative process involving degeneration, inflammation, axon re-growth and innervation of the denervated target, and finally functional recovery. In this thesis I …
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Peripheral nerve regeneration through collagen devices with different in vivo degradation characteristics
… than 200,000 people are treated each year for peripheral nerve injuries that require surgery. Functional recovery of motor and sensory capability is limited following autograft, the most common procedure for peripheral nerve repair. Tubulation repair of a transected peripheral nerve presents an …
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The Role of Slit/Robo Signalling in Peripheral Nerve Regeneration
The role of Slit/Robo signalling in peripheral nerve regeneration. Slit/Robo chemorepulsive signalling has been shown to play a role in axon pathfinding during the development of the central nervous system. There is evidence that Slit/Robo are expressed in the adult intact and injured peripheral …
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Design and evaluation of neuroregenerative properties of 4D hydrogel scaffolds
… research target due to its relevance in peripheral nerve repair, and to its connection to the non-regenerative central nervous system (CNS). Severe peripheral nerve injuries have a limited regenerative capacity, with interventions typically not leading to full functional recovery. Ways to …
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Novel signalling pathways resolving the inflammatory response during peripheral nerve regeneration
Introduction. The peripheral nervous system has the remarkable capacity to regenerate and restore function following damage or disease. Instrumental in this regenerative process are macrophages, Schwann cells and the production of inflammatory cytokines. The production of inflammatory cytokines …
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Crosslinked Hyaluronic Acid Hydrogel Networks Designed as Mechanical Actuators
… applications, such as wound closure/healing and nerve regeneration, where polymeric actuators have been underutilized. These applications however call for a polymer system that can actuate at controlled slow speeds and sustain this actuation for several days. At present there is a lack of such …