Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"Peripheral circulation"”.
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Enterohepatic Circulation of Estrogens in the Domestic Pig, Sus Scrofa
Enterohepatic circulation (EHC) of estrogen involves secretion of estrogen in bile by the liver, release of bile from the gallbladder into the gastrointestinal tract, absorption of estrogen in bile from the gastrointestinal tract into venous blood going to the liver, and secretion of estrogen by …
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Studies of the cardiovascular effects of inotropic agents and vasodilators on the pulmonary and systemic circulation in man
… primarily affect the heart or components of the peripheral circulation and may have adverse as well as beneficial effects. Although animal studies can give some indication of the mode of action, such drugs should be evaluated both by measurement of their effects on the circulation and by …
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The role of megakaryocytes and platelets in infection and immunothrombosis
… one of the most abundant cell types in the peripheral circulation. While platelets are studied for their various roles in inflammation, the role of MKs within the innate immune system has not been explored. In a series of comprehensive in vitro experiments, we have demonstrated that both …
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Studies of Blood Leukocytes and Peritoneal Fluids in Some Acute Abdominal Conditions and in Shock
… and later to withdrawal of leukocytes from the peripheral circulation into vessels of the viscera. In substance these are the two theories that prevail today. | There is much conflicting evidence on the mechanism of leukopenia. Some of it is favorable to either or the two theories mentioned, …
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Use of Machine Learning for Automated Convergence of Numerical Iterative Schemes
… and effectively. The fluid flow model integrates peripheral circulation using a lumped-parameter model (LPM) to capture the field pressures and flows across various circulatory compartments. Machine learning opens the doors to an intelligent approach for iterative solutions by replacing prescribed …
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Estimation of cardiovascular indices by analysis of the arterial blood pressure signal
… volume (SV), cardiac output (CO), and total peripheral resistance (TPR) by analysis of the arterial blood pressure (ABP) signal. The algorithms incorporate cardiovascular physiology within the framework of a generalized Windkessel model, which is a widely accepted cardiovascular model. …
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Circulating microparticles: a risk factor for recurrent abortion in women at the University Teaching Hospital
… been found to be increased in the uteroplacental circulation in pregnancy, as such microparticles may be directly or indirectly associated with pregnancy loss. With abortion cases accounting for approximately 80% of cases presenting at the Obstetrics and Gynaecology emergency ward at The …
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Circulating microparticles: a risk factor for recurrent abortion in women at the University Teaching Hospital
… been found to be increased in the uteroplacental circulation in pregnancy, as such microparticles may be directly or indirectly associated with pregnancy loss. With abortion cases accounting for approximately 80% of cases presenting at the Obstetrics and Gynaecology emergency ward at The …
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The Effect Of Leucogenenol and Chemotherapy on B and T Lymphocyte Populations in Mice Infected With Friend Virus Leukemia
… to total body weight ratios, survival times, peripheral nucleated cell counts and peripheral white blood cell differentials were also monitored to show the progression of the FV leukemia and the effects of leucogenenol and chemotherapy. Findings. The effect of the leucogenenol was to initially …
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Natriuretic Peptides and the Microcirkulation in Heart Failure Patients
… HF leads to vascular dysfunction in the general circulation but the interpretation of this is not clear. In our studies we have focussed on defining endothelial and smooth muscle dysfunction in the microvasculature of HF patients and correlating this dysfunction with the disease state. This …
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A Novel Exo-Proteomic Approach to the Study of Traumatic Brain Injury
… of trauma-specific biomarkers present in peripheral blood may present a viable alternative. However, the likely degradation of neuronal proteins in the peripheral circulation is an obstacle. Exosomes, small membrane vesicles known to carry proteins and injury-specific biomarkers, may help …
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The Fate of Folic Acid and Related Compounds in the Rat
… acid/kg, radioactivity was detected in the peripheral circulation 10 minutes after administration. Pteroyl-L-glutemic acid was absorbed without metabolism and was present in systemic blood for up to 4 hours after administration. With doses of pteroyl-L-glutamic acid from 3.1 to 56ug/kg …
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Peripheral regulation of food intake in the domestic fowl
Four studies were performed to examine peripheral factors involved with food intake regulation in the domestic fowl. In the first study, the mechanism by which tryptophan depresses food intake was clarified. Intraperitoneal injections of tryptophan methyl ester were demonstrated to inhibit feeding …
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Monocytic Cells Mediate Granulocyte-Colony Stimulating Factor-Induced Mobilization of Hematopoietic Stem and Progenitor Cells
… is altered and HSPCs are released into the peripheral circulation through a process known as mobilization. Granulocyte-colony stimulating factor: G-CSF), a hematopoietic growth factor, is the most widely-used mobilizing agent clinically. However, the mechanisms by which G-CSF elicits HSPC …
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Monocytes as Gene Therapy Vectors for the Treatment of Alzheimer’s Disease
… monocytes to characterize the kinetics that peripheral monocytes display once injected into the circulation. We determined the half life of bone marrow derived monocytes after one injection into the peripheral circulation, and found this time to be 1.5 hours post injection. We also examined …
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Estimating antimalarial drug activity in vivo: an interdisciplinary approach combing novel experimental data with mathematical modelling
… is the rapid clearance of parasites from the peripheral circulation called 'parasite clearance'. Short parasite clearance half-lives are interpreted to mean rapid drug action. These parasite clearance data are used to parameterise PK/PD models that relate the drug's concentration with its …
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B and T Lymphocytes in Human Pregnancy
… In conjunction with this increased reactivity, peripheral T lymphocytes may be migrating away from the peripheral circulation.</p>
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Regulatory T cells and circulating cytokines : novel prognostic markers in squamous cells carcinoma of the head & neck
… regarding IL10, IL12 and Treg cells in the peripheral circulation of HNSCC patients with their levels and function in tumour tissue and TIL is recommended.
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Monocyte Derived Dendritic Cells: Sentinels and Translators of Immune Response to Staphylococcus aureus
… proliferation of T cells collected from the peripheral circulation of cows with a history of <i>S. aureus</i> mastitis. Subsequent characterization of the proliferating T cells identified the presence of memory T cells. Finally, we identified a unique population of DEC205⁺CD8<sup>a+</sup> in …
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Precision Adjuvant Design Enabling Tailored Nanoparticle Immunization Platforms for Oxycodone and Other Substance Abuse Vaccines
… capable of sequestering drug molecules in the peripheral circulation provide a non‑addictive, durable alternative. However, their success hinges on judicious adjuvant selection and optimized antigen delivery. This dissertation integrates systematic adjuvant characterization with …
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