Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 36 for “"Peripheral blood lymphocytes"”.
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Response of Peripheral Blood Lymphocytes from RAO-affected Horses to b2-Agonist Stimulation
… (β2-AR). In other species, β2-agonists promote peripheral blood lymphocyte (PBL) cytokine expression towards a pro-inflammatory phenotype. RAO horses are a good model for evaluating chronic changes in human asthma. However, little is known about the effect of β2-agonist stimulation on equine …
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The analysis of radiation-induced micronuclei in peripheral blood lymphocytes for purpose of biological dosimetry
… assay as a biodosimetric method using lymphocytes irradiated in vivo. The approach adopted to achieve this was to estimate whole body doses by relating micronuclei yields in patients undergoing radiotherapy treatment with an in vitro radiation dose-response curve. These biologically …
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Effects of Graphene Oxide in vitro on DNA Damage in Human Whole Blood and Peripheral Blood Lymphocytes from Healthy individuals and Pulmonary Disease Patients: Asthma, COPD, and Lung Cancer
… 1 mg/mL) in vitro on DNA damage in human whole blood and peripheral blood lymphocytes (PBL) from real-life patients diagnosed with chronic pulmonary diseases [asthma, chronic obstructive pulmonary disease (COPD), and lung cancer], and genotoxic endpoints compared with those from healthy control …
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Effects of Graphene Oxide in vitro on DNA Damage in Human Whole Blood and Peripheral Blood Lymphocytes from Healthy individuals and Pulmonary Disease Patients: Asthma, COPD, and Lung Cancer
… 1 mg/mL) in vitro on DNA damage in human whole blood and peripheral blood lymphocytes (PBL) from real-life patients diagnosed with chronic pulmonary diseases [asthma, chronic obstructive pulmonary disease (COPD), and lung cancer], and genotoxic endpoints compared with those from healthy control …
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Genotoxic effects of NSAIDs and hydrocortisone in bulk and nano forms in lymphocytes from patients with haematological cancers
… in their bulk and nano forms were evaluated on peripheral blood lymphocytes of healthy donors using the comet assay and the micronucleus assay. In order to determine any anti-cancer effects, these agents were also tested in peripheral blood lymphocytes in patients with haematological cancers. …
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Immune Responses and Hematologic Alterations in Splenectomized Pigs Experimentally Infected With Eperythrozoon Suis: I. A Possible Animal Model for Cold Agglutinin Disease in Man
… course of the disease was monitored by complete blood counts and serum chemical determinations. Cell-mediated immune responses were measured by the uptake of ('3)H-thymidine (lymphocyte blastogenesis) following the incubation in vitro of peripheral blood lymphocytes with phytohemagglutinin …
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Das T-Zell-Rezeptor-Repertoire bei der Polymyositis
… (PM) is an autoimmune disease cased by CD8+ T lymphocytes that destroy HLA class I-expressing skeletal muscle fibres. Recently we demonstrated that the autoaggressive T lymphocytes in PM muscle are clonally expanded. We employed a new PCR-based method to identify and characterize clonally …
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Imunologiniai atvirų ir laparoskopinių prostatos vėžio operacijų skirtumai /
… be reflected in the phenotypic alteration of the peripheral blood lymphocytes. We compared the patterns of immunophenotypic variations occurring in blood of patients following open and laparoscopic prostatectomies. We assessed the relationship between immunophenotype changes and clinical data …
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Cytogenetic Analysis Of Depleted Uranium Exposure And Age-Dependent Susceptibility To Ionizing Radiation
… body burden by measuring chromosome damage in peripheral blood lymphocytes with the cytokinesis blocked micronucleus assay (CBMN) and fluorescence in situ hybridization (FISH) whole chromosome painting. Study subjects are Gulf War I Veterans exposed to DU during friendly fire incidents in 1991 …
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In vitro chemically-induced DNA damage in cancer patients and healthy individuals. The effect of genotoxic compounds in cells from polyposis coli, colon cancer patients and healthy individuals.
In the present study DNA damage was measured in peripheral blood lymphocytes from polyposis coli and colorectal cancer patients, treated with different dietary and environmental compounds and compared with lymphocytes from healthy individuals. In addition, confounding factors such as age, gender, …
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DNA damage and nutrient status as risk factors for mild cognitive impairment and Alzheimer’s disease
… tissues, such as brain, buccal cells and peripheral blood lymphocytes. Previous studies have shown that mild cognitive impairment (MCI) may reflect the early stages of more pronounced neurodegenerative disorders such as AD. To date, conclusive diagnostic tests and the impact of dietary …
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The role of tetraspanin pretein CD63 in humna immunodeficiency virus type 1 infection and replication
… which did not inhibit HIV replication in peripheral blood lymphocytes or in two CD4+ cell lines tested. To confirm the requirement for CD63 in HIV replication, CD63 expression in cells was decreased by RNA interference using short interfering RNAs (siRNA). Inhibition of HIV replication was …
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The Indirect Effect of BVDV on Immune Suppression: The Role of Infected Macrophages in Lymphocyte Apoptosis
… BVD especially, the apoptotic effect induced on lymphocytes. We infected bovine monocyte-derived macrophages (MDM) with either high or low virulent strains of cytopathogenic or non-cytopathogenic strains of BVDV and collected supernatants that were used for treatment of the fresh peripheral blood …
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Zeta-Ketten Expression bei Patienten mit SCCHN und dendritische Zellen als Stimulatoren für T-Zellen In Vitro
… The expression of the TCR -chain of both peripheral blood lymphocytes (PBLs) and tumor infiltrating lymphocytes (TILs) has been analysed in patients with SCCHN and correlated to clinical data. Methods TIL and PBL from 47 patients with SCCHN were obtained. To determine expression of the …
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Molecular defects in B lymphocytes from patients with CVID- syndrome
… In vitro stimulation experiments with CVID peripheral blood B cells (CD19+) showed, that CVID B cells could secrete IgM, but no or only few IgG. Transplantation of human peripheral blood lymphocytes of two CVID patients into the spleen of immunodeficient mice showed that the functional B …
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Untersuchungen HLA-Klasse II-assoziierter, T-zellvermittelter Autoimmunität im humanisierten SCID-Mausmodell des Pemphigus vulgaris
… was to examine the function of autoreactive T-lymphocytes in the regulation of autoantibody production and the importance of immunogenetic factors in T-cell activation in an in vivo model. The humanized SCID mouse model allows the adoptive transfer of human peripheral blood lymphocytes (PBL) to …
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Elucidation of antigenic epitopes on the rubella virus E1 glycoprotein
… the entire El sequence were screened with human peripheral blood lymphocytes and the corresponding sera to examine the distribution of antigenic domains. El glycoprotein was also the target of viral neutralizing (VN) and hemagglutinin (HA) epitope mapping studies. Deletion mutants of El were …
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Lymphocyte populations and their relationship to cell-mediated immune responses in aflatoxin-treated guinea pigs
… hypersensitivity (DTH) was used to evaluate T lymphocytes or macrophages from aflatoxin-treated guinea pigs. The skin test responses of both nontreated guinea pigs receiving peritoneal exudate cells (PEC) from aflatoxin-treated guinea pigs and aflatoxin-treated guinea pigs receiving PEC from …
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Studies on the synergic activity of a three-drug cocktail active against cisplatin-resistant human leukemia and carcinoma cells
… A2780 cells, and ex vivo cultures of human peripheral blood lymphocytes from healthy donors, were used as cell models to characterize the cytotoxic activity of both binary and ternary drug combinations. Experimental Design (ED) and Artificial Neural Network (ANN) were used for setting …
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The effect of oxidative stress in lymphocytes from patients with inflammatory bowel disease and various cancer states compared with healthy control individuals.
In the present investigation peripheral blood lymphocytes from patients with inflammatory bowel disease (IBD) and different cancer states were treated with various agents and compared with lymphocytes from healthy control individuals (HCI) treated in the same way and measured in the Comet assay. …
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