Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"Peripheral Tolerance"”.
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B cell signalling in mechanisms of central and peripheral tolerance
Tolerance against self is a necessary feature of the immune system to prevent autoimmunity. Hence during B cell development, a number of central and peripheral developmental checkpoints ensure the deletion of self-reactive B cells and selection of tolerant B cells. For example, antigen-driven …
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Dendritic Cell Regulation of Peripheral Tolerance in Polyclonal T Cell Repertoires
… encounter with antigen will be immunity or tolerance. Using an antibody against the DEC-205 receptor, antigens have been delivered specifically to DCs in vivo. Under steady state conditions, such presentation of antigen leads to peripheral tolerance in transgenic T cells, either by deletion, …
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Design of Antigen-Specific Immunotherapies Through Modulation of Peripheral Tolerance Pathways
… of therapeutics for the induction of immune tolerance designed to direct the effects of small molecule immunosuppressants through conjugation to the autoantigen of interest (Chapter 2). This strategy has proven successful in ameliorating paralytic symptoms in a murine model of multiple …
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Role of Splenic B Cells and Gamma Delta T Cells in the Induction of Peripheral Tolerance Elicited Through the Anterior Chamber of the Eye
… immune deviation (ACAID) is a form of peripheral tolerance that is induced by introducing antigens into the anterior chamber (AC) of the eye, and is maintained by antigen-specific regulatory T cells (Tregs). ACAID regulates harmful immune responses that can lead to irreparable injury to …
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The role of the atypical chemokine receptor CCX-CKR in thymocyte development and its influence on the link between innate and adaptive immunity through regulation of dendritic cell migration.
… of a self-MHC restricted and self-tolerant peripheral T cell repertoire. Yet mechanisms outside of transcriptional control that are involved in thymic chemokine regulation have not been well characterised. The aim of this study was to thoroughly investigate the role of CCX-CKR expression on …
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Role of the CTLA-4 receptor in regulatory T cell development, homeostasis and function
… transcription factor Foxp3 and exert dominant peripheral tolerance to maintain immune homeostasis. It is therefore important to fully understand the underlying mechanisms of Treg development, homeostasis and function due to the positive and negative effects that therapeutic manipulation could …
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Soluble Peptide Treatment Reverses CD8 T Cell-Induced Disease in a Mouse Model of Spontaneous Tissue-Selective Autoimmunity
… This model can inform us about mechanisms of peripheral tolerance and potential therapies for autoimmune diseases in which specific molecular targets are known.
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Cellular requirements for antibody production in a novel LPS-enhanced model of autoimmune myasthenia gravis
… a T cell-independent adjuvant known to abrogate peripheral tolerance. For the first time, the potential of LPS to induce antigenspecific B cell responses to acetylcholine receptor (AChR) in myasthenia gravis (MG) was evaluated in wild type (WT), CD4-/-, and CD8-/- C57BL/6 mice. Historically, …
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Hyporesponsive synovial fluid T cells in rheumatoid Arthritis
… other models of T cell anergy (clonal anergy and peripheral tolerance), T cell suppressions (TR1 cells and CD25+ TS cells) and replicative senescent T cells suggested that this kind of T cell hyporesponsiveness is different. T cell hyporesponsiveness is obviously induced by a soluble factor, which …
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Investigation of T cell signalling events regulating immunity and tolerance in vivo
… but also for a state of antigen-specific tolerance to be elicited against harmless antigens. A breakdown in such tolerance can result in the development of a variety of autoimmune diseases including rheumatoid arthritis, Type 1 diabetes, inflammatory bowel disease and coeliac disease. …
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Investigations into the Biological Roles of the E3 ligase Ariadne 2/TRIAD1
… and is a novel regulator in the maintenance of peripheral tolerance and the pathogenesis of autoimmunity.
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Roles for the E3 Ligase Itch in Immune Response Modulation
… in Itch deficient CD4+ T cells. Inadequacies in peripheral tolerance mechanisms were observed based on oral tolerance studies. Itch deficiency was found to directly contribute to the CD4+ bias towards T helper type-2 (Th2) differentiation observed in a mice. Itch modulation of Th2 differentiation …
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The Expression of the Zinc Finger Transcription Factor zDC Defines the Classical Dendritic Cell Lineage
… due to their roles in the maintenance of immune tolerance and the induction of adaptive immune responses. However, distinguishing cDCs from other myeloid populations is complicated by the lack of highly specific cDC markers. For example, high expression of the integrin CD11c is used to define …
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Active Inhibition of T Cell Proliferation by Monocytes
… two receptors in activation and inhibition of peripheral blood mononuclear cells. In this study, it is shown that the inhibition of OKT3-dependent T cell activation correlates with metabolic activation of antigen presenting cells. In contrast, inhibition of lectin- and superantigen-mediated T …
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The Function of LAT in T Cell Activation and Autoimmunity
… implicating a breakdown of both central and peripheral tolerance. The phenotype observed in LAT-/- mice is even more severe.T cells are absent in the periphery of these mice due to a complete block in thymocyte development at the DN3 stage thereby making it difficult to study the …
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Dendritische Zellen bei der Intra- und Extrauteringravidität : mögliche Bedeutung für die feto-maternale Toleranz
… hand DC play a central role in the induction of peripheral tolerance. The presence of different maturation states of DC has been described at the feto-maternal implantation site of intrauterine pregnancies (IUP). It is assumed that the interaction of immature DC with natural killer (NK)-cells …
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Functional characterization of rat CTLA-4 and CD25+CD4+ regulatory T cells
… tipping ongoing autoimmune responses toward selftolerance.
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Clonal Studies of Human B Cells
… these B cells are normally eliminated by tolerance mechanisms during development. The extent of tolerization manifest among human B cells that recognize both self- and foreign antigens is unknown. Here, I and my colleagues use an efficient single B-cell culture method and multiplexed …