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Showing 1 to 20 of 22 for “"Peripheral Nerve Regeneration"”.
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KERATIN BIOMATERIAL SCAFFOLDS FOR PERIPHERAL NERVE REGENERATION
Peripheral nerve injury is a relevant clinical concern. Although surgical management of these injuries has improved over time, the current "gold standard" for nerve transection injury, autograft, has many limitations. Nerve conduits are used as an alternative to autograft surgery but they are …
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Regulation of peripheral nerve regeneration by the mTOR pathway
… for regrowth after damage, neurons in the peripheral nervous system: PNS) have a robust ability to regenerate their axons following injury. Successful regeneration depends upon both extrinsic cues in the environment and the activation of intrinsic mechanisms to promote regrowth. A number of …
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The Role of Slit/Robo Signalling in Peripheral Nerve Regeneration
The role of Slit/Robo signalling in peripheral nerve regeneration. Slit/Robo chemorepulsive signalling has been shown to play a role in axon pathfinding during the development of the central nervous system. There is evidence that Slit/Robo are expressed in the adult intact and injured peripheral …
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Novel signalling pathways resolving the inflammatory response during peripheral nerve regeneration
Introduction. The peripheral nervous system has the remarkable capacity to regenerate and restore function following damage or disease. Instrumental in this regenerative process are macrophages, Schwann cells and the production of inflammatory cytokines. The production of inflammatory cytokines …
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Influence of implant parameters on the mechanisms of peripheral nerve regeneration
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 1998.
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Imaging studies of peripheral nerve regeneration induced by porous collagen biomaterials
… urgent need to develop treatments for inducing regeneration in injured organs. Porous collagen-based scaffolds have been utilized clinically to induce regeneration in skin and peripheral nerves, however still there is no complete explanation about the underlying mechanism. This thesis utilizes …
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Peripheral nerve regeneration through collagen devices with different in vivo degradation characteristics
… than 200,000 people are treated each year for peripheral nerve injuries that require surgery. Functional recovery of motor and sensory capability is limited following autograft, the most common procedure for peripheral nerve repair. Tubulation repair of a transected peripheral nerve presents an …
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Mechanical modeling of tissue response during early stage entubulated peripheral nerve regeneration
After severe peripheral nerve injury, such as transection, regeneration has been observed over variable gap lengths with the use of the nerve stump entubulation method. Following entubulation, exudate from transected nerve stumps coagulates into a fibrin matrix within the entubulated space by the …
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A freeze-drying process for fabrication of polymeric bridges for peripheral nerve regeneration
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 1988.
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Peripheral nerve regeneration through tubular devices : a comparison of assays of device effectiveness
Peripheral nerve injury affects nearly 200,000 patients annually in the United States and unless treated results in paralysis of skeletal muscle and loss of sensation. Previous studies in this laboratory have focused on comparing the effectiveness of various tubular devices in repairing …
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Investigation of Keratin and Keratin-Containing Composite Biomaterials: Applications in Peripheral Nerve Regeneration
… vitro and in vivo settings for different tissue regeneration applications. Over three decades, keratin extraction technology has been continuously modified, and these differences in extraction processes have distinct effects on the characteristics of the end product. In this work, we examine the …
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Molecular biology of peripheral nerve regeneration: Expression and role of Netrin-1, DCC and Runx2
Damage to the peripheral nerves causes a series of molecular, cellular, and structural changes critical to initiating a successful regenerative process involving degeneration, inflammation, axon re-growth and innervation of the denervated target, and finally functional recovery. In this thesis I …
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Neuromuscular Synaptic Proteins In Development And Regeneration
Following injury, peripheral nerves reestablish neuromuscular connections with their developmental targets. While the molecular pathways that govern peripheral nerve development and neuromuscular synapse formation are mostly understood, it is unclear whether the same pathways are reemployed to …
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Sensorimotor Recovery, Functional and Structural Brain Plasticity, and the Development of Chronic Pain Following Upper Limb Peripheral Nerve Transection and Microsurgical Repair
Following peripheral nerve transection and microsurgical repair (PNIr) most patients retain significant sensorimotor impairments, a proportion of which also develop chronic neuropathic pain. Individual psychological factors may contribute to the development, intensity and duration of chronic pain. …
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Assessment of collagen based polymer scaffolds for tissue engineering
… scaffolds has seen promise to date in skin regeneration templates, hollow nerve guides for peripheral nerve regeneration, and conjunctiva regeneration. Future applications appear to be directed toward both in vivo and in vitro engineering of complex cellular systems, with significant …
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Fabrication and evaluation of a collagen-based fiber-gel three-dimensional construct for peripheral nerve repair
Nerve regeneration following a peripheral nerve injury often relies on growth cone- mediated guidance and the presence of Schwann cells to support the regenerating axons and remyelinate portions of denervated nerve pathways. The emphasis of this work is to develop a synthetic nervous tissue …
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Investigation of electrospun fibrous scaffolds, locally delivered anti-inflammatory drugs, and neural stem cells for promoting nerve regeneration
The organization and intricacy of the central and peripheral nervous systems pose special criteria for the selection of a suitable scaffold to aid in regeneration. The scaffold must have sufficient mechanical strength while providing an intricate network of passageways for axons, Schwann cells, …
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Cell-mediated contraction & induced regeneration of the injured peripheral nerve
… in adult mammalian organs, including the sciatic nerve following neurotmesis. Without experimental intervention the defect closes rapidly via contraction of transected nerve stumps by a thick, cohesive capsule of myofibroblasts (MFB) and subsequent collagen synthesis (scar), leading to a painful …
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