Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"Peripheral Nerve Injury"”.
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Sex-dependent and Sex-independent Gene Regulation after Peripheral Nerve Injury
Peripheral nerve injury (PNI) induces cascades of gene expression changes in the central nervous system (CNS). However, there are still many uncertainties regarding the mechanisms of gene regulation that are sex-dependent and sex-independent. In this study, I examined the sex differences and …
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Biomedical and Psychosocial Factors Associated with Pain and Disability after Peripheral Nerve Injury
… in patients following traumatic upper extremity nerve injuries. This was approached by conducting 3 studies. The first study surveyed peripheral nerve surgeons regarding the assessment of pain in patients with nerve injury. The results showed that only 52% of surgeons always evaluate pain in …
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Effects of Electrical Stimulation and Testosterone in Translational Models of Peripheral Nerve Injury
<p>As functional recovery following peripheral nerve injury is dependent upon successful regeneration and target reconnection, combinatorial treatments that enhance different regeneration events may be required for recovery from severe injuries. The neurotherapeutic effects of electrical …
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Immunoregulation of the central response to peripheral nerve injury: motoneuron survival and relevance to ALS
Facial nerve axotomy (FNA) in immunodeficient mice causes significantly more facial motoneuron (FMN) loss relative to wild type (WT), indicating that the immune system is neuroprotective. Further studies reveal that both CD4+ T cells and interleukin 10 (IL-10) act centrally to promote neuronal …
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Growth Factor Delivery From Fibrin Matrics Containing Affinity-Based Delivery Systems To Treat Peripheral Nerve Injury
… and to serve as a potential treatment for peripheral nerve injury. The use of an affinity-based delivery system: ABDS) with growth factors in a nerve guidance conduit: NGC) was hypothesized to promote nerve regeneration and functional recovery following a critical nerve defect. Evaluation …
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THE EFFECTS OF AGE, GH AND IGF-1 ON NEUROMUSCULAR RECOVERY FOLLOWING NERVE TRANSECTION
… most important determinant of recovery after peripheral nerve injury. With aging, there is a decrease in circulating levels of growth hormone (GH) and insulin-like-growth factor 1 (IGF-1). The purpose of this research was to examine the effect of age, GH and IGF-1 on neuromuscular recovery …
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Median and Ulnar Nerve Injuries in Children and Adolescents- Long-term outcome and Cerebral reorganisation
A peripheral nerve injury may lead to serious disability and influence the individual´s quality of life. It is considered that children can regain better sensory and motor function after a peripheral nerve injury, but the exact mechanism behind such superior recovery is not known. The aim of the …
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Inflammasome mediated response to biomaterials implanted in the peripheral nervous system
… neurological function in brain, spinal cord or peripheral nerve injury patients. However, neural interfaces require selectivity and long-term stability, which are compromised by the physiological host-implant response (foreign body reaction - FBR), which surrounds the implant with fibrotic …
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KERATIN BIOMATERIAL SCAFFOLDS FOR PERIPHERAL NERVE REGENERATION
Peripheral nerve injury is a relevant clinical concern. Although surgical management of these injuries has improved over time, the current "gold standard" for nerve transection injury, autograft, has many limitations. Nerve conduits are used as an alternative to autograft surgery but they are …
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Molecular biology of peripheral nerve regeneration: Expression and role of Netrin-1, DCC and Runx2
Damage to the peripheral nerves causes a series of molecular, cellular, and structural changes critical to initiating a successful regenerative process involving degeneration, inflammation, axon re-growth and innervation of the denervated target, and finally functional recovery. In this thesis I …
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Biohybrid Peripheral Neural Interfaces: Combining Cell Transplantation and Flexible Electronics for Functional Neurological Restoration
Peripheral nerve injuries result in a disconnection in the nervous system communication and a consequent loss in neurological function. Currently, there is very limited treatment for these conditions. Neuroprosthetics and cell transplantation are promising approaches to restore lost neurological …
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Development and translation of label-free functional microscopy based on optical coherence tomography
… an imaging platform for preclinical study of peripheral nerve injury and repair. The vascularization is assessed by angiographic OCT, and the degree of myelination is measured by PS-OCT. These results confirm that the OCT platform can reveal new insights into preclinical studies of nerve …
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Novel signalling pathways resolving the inflammatory response during peripheral nerve regeneration
Introduction. The peripheral nervous system has the remarkable capacity to regenerate and restore function following damage or disease. Instrumental in this regenerative process are macrophages, Schwann cells and the production of inflammatory cytokines. The production of inflammatory cytokines …
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The morphology, neurochemistry, and consequences of sympathosensory plexuses
… depend on the function of neurotrophins such as nerve growth factor (NGF). One population of neurons that rely heavily on NGF for axonal growth and survival is the postganglionic sympathetic neurons. Trauma or disease resulting in injury to the peripheral nervous system causes an increase in the …
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Fabrication and evaluation of a collagen-based fiber-gel three-dimensional construct for peripheral nerve repair
Nerve regeneration following a peripheral nerve injury often relies on growth cone- mediated guidance and the presence of Schwann cells to support the regenerating axons and remyelinate portions of denervated nerve pathways. The emphasis of this work is to develop a synthetic nervous tissue …
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Effects of electrical stimulation and testosterone on regeneration-associated gene expression and functional recovery in a rat model of sciatic nerve crush injury
Although peripheral motoneurons are phenotypically endowed with robust regenerative capacity, functional recovery is often suboptimal following peripheral nerve injury (PNI). Research to date indicates that the greatest success in achieving full functional recovery will require the use of a …
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Molecular Expression of Neuroprotective and Neurodestructive Signaling Systems Following Axotomy-Induced Target Disconnection: Relevance to ALS
… leads to MN degeneration. Our lab utilizes a peripheral nerve injury model to investigate the mechanisms of MN survival in the pre-symptomatic SOD1 mouse. We have shown SOD1 mice display enhanced facial MN (FMN) cell loss following a facial nerve axotomy, compared to wild-type (WT) mice. …
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