Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Periostin"”.
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Glioma produced periostin attracts human neural stem cells
… with various brain tumor samples showed that periostin (POSTN) among these factors, known for its role in angiogenesis and invasion during tumor development, was specifically expressed only in glioblastoma multiforms, malignancty tumors. We are also found that a recombinant human POSTN …
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Periostin-like-factor in tissue repair and remodeling
Perisotin-like-factor (PLF) is a member of the Fasciclin family of proteins, which are characterized by the presence of 150 amino acid long conserved Fasciclin domains. Members of this family have been implicated in numerous cellular processes like adhesion, migration, axonal guidance and growth …
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Determining if the Developmental Origin of Cardiac Fibroblasts Determines the Fate of Activation in Adult-Onset Hypertension
… are essential regulators of fibrosis [7, 9, 10]. Periostin expression is canonically known as a marker of the activated fibroblast state in disease, but it is also upregulated during postnatal day 1 through postnatal day 11 [6] in development. We hypothesize that a neonatal Periostin- expressing …
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Targeting Aldehyde Dehydrogenases in NF2-null Meningioma and Schwannoma
… vestibular ganglia schwannomas in the NF2fl/fl Periostin-CRE mouse schwannoma model, and in meningioma murine orthotopic xenograft tumours.<br/><br/>In summary, this project has revealed a significant role for ALDH enzymes, particularly ALDH1A3, in driving tumour growth in meningioma cells. …
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Transgenic use of SMAD7 to suppress TGFß signaling during mouse development
… in a subset of post-migratory NCC lineages (via Periostin-Cre mice, after the NCC had reached their target organs and undergone differentiation). Induction of Smad7 within NCC significantly suppressed TGFβ superfamily signaling, as revealed via diminished phosphorylation levels of both Smad1/5/8 …
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Proepicardial Cell Differentiation During Cardiac Development
… extracellular matrix (ECM) molecules including periostin, tenascin, and collagen. The expression and localization of these ECM proteins is critical to the proper development and function of the heart. These phenomenons were inhibited by the addition of a TGFb family inhibitor (SB 431542). Our …
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PATHOLOGY OF THE UROGENITAL TRACT IN DOMESTIC ANIMALS
… of an extracellular matrix protein called periostin in normal bladder and dog urothelial carcinomas. The tumour microenvironment is considered one of the main players in cancer development and progression and may influence the behaviour of cancer cells. Periostin (POSTN) is an extracellular …
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Elucidating the role of LARP6 in cardiovascular remodeling
… by the number of interstitial cells expressing periostin. RNA sequencing revealed widespread changes to the cardiac transcriptome in response to LARP6 overexpression. Overall, cardiomyocyte-derived LARP6 is a multifunctional protein that exerts cardioprotective effects in the setting of …
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Proteomics characterization of HPV-independent Vulvar Cancer Tumour Progression and Metastasis by Mass Spectrometry
… patients in LFQ experiment. As the result, the Periostin (POSTN) demonstrated significantly lower abundance in Indigenous vulvar cancers as compared to other non-Indigenous cancers. Besides, NDRG1 and Ras-related protein 1A (RAP1A) were identified able to determine Indigenous VSCCs with and …