Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Period2"”.
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Modulation of the Hippocampal Neurogenic Program by the Circadian Clock Machinery and the small GTPase, Rasd1/ Dexras1
… feedback loop (TTFL), which includes Bmal1 and Period2. In this thesis, I demonstrate the presence of the molecular clock and of rhythmic cell proliferation in the SGZ. The absence of Period2 abolishes the gating of cell cycle entrance of QNPs, whereas the genetic ablation of Bmal1 results in …
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Insights on the Regulation of the PERIOD 2 Gene in the Cellular Response to DNA Damage
… in synchrony with environmental changes. PERIOD2 (PER2) is a core component of the circadian clock and a candidate tumor suppressor as its knockout expression results in a cancer-prone animal. p53 is an effector in the DNA damage response and regulates downstream effectors by …
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Investigation into the molecular mechanisms underlying circadian rhythm disruption and human cancer
Human Period2 (PER2) is one of the core mammalian clock factors known to be rhythmically expressed throughout the body and directly binds to the tumor suppressor p53 and its negative regulator, the oncogenic mouse double minute-2 (MDM2) protein. PER2 modulates p53 transcriptional activity by …
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Interlocking mechanisms regulating the circadian clock response to DNA damage
… established that the core clock component PERIOD2 (PER2) binds to the tumor suppressor protein p53, a key regulatory checkpoint component that modulates cell cycle progression and the cellular response to genotoxic stress. PER2 binding to p53 modulates p53's stability, cellular …
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Using Translational Switching to Investigate the SCN Clockwork
… translationally switchable Bmal1 (tsBMAL1) and Period2 (tsPER2), as well as using a translationally switchable copy of CRY1 (tsCRY1) developed previously in the lab, to investigate the SCN clockwork. First, I show how generation of tsBMAL1 provided conditional and reversible control of …
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The Translationally Controlled Tumor Protein (TCTP) associates to and destabilizes the Circadian Factor Period 2 (Per2)
Period 2 (Per2) is a core circadian factor responsible for its own negative regulation. It operates in the circadian clock, which affects multiple biological functions such as metabolic rate, hormone release, and core body temperature. The Per2 protein functions directly with factors in other …
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Development of fish embryonic stem cell lines as tools for basic and applied studies of interest in aquaculture
… clock (clock, bmal1, cryptochrome1a, period1, period2 and period3) under controlled light-dark cycles and constant conditions (constant light, constant dark), as well as the response to nocturnal light pulses in this cell line. This study has allowed us to demonstrate that SAEC-H7 cells contain …