Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 69 for “"Period-2"”.
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Insights on the Regulation of the PERIOD 2 Gene in the Cellular Response to DNA Damage
… in synchrony with environmental changes. PERIOD2 (PER2) is a core component of the circadian clock and a candidate tumor suppressor as its knockout expression results in a cancer-prone animal. p53 is an effector in the DNA damage response and regulates downstream effectors by …
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The Translationally Controlled Tumor Protein (TCTP) associates to and destabilizes the Circadian Factor Period 2 (Per2)
Period 2 (Per2) is a core circadian factor responsible for its own negative regulation. It operates in the circadian clock, which affects multiple biological functions such as metabolic rate, hormone release, and core body temperature. The Per2 protein functions directly with factors in other …
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Identification and Regulatory Role of E3 Ligases in the Time-Dependent Degradation of the Circadian Factor Period 2
… thesis (Chapter 2-3) focuses on the function of Period 2 (Per2), a key regulatory component of the negative feedback arm of the clock and tumor suppressor protein, as a modulator of cell cycle response. We found that Per2 binds the C-terminus end of the tumor suppressor p53 thus forming a …
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Circadian Control of Cell Cycle Progression
… to the deregulation of cell cycle checkpoints 1. Period 2 (Per2) is a tumor suppressor that oscillate in expression in a 24-hour cycle 2, 3. Here, we show that Per2 interacts with the tumor suppressor protein p53. Both G1 and G2 checkpoint pathways involve a p53 dependent pathway which can trigger …
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Effects of elevated testicular temperature on viability of cryopreserved semen and morphological characteristics of ejaculated spermatozoa
… collection days were grouped: days -6, -3, 0 = Period 1 (d 0 = day of testis coverage after semen collection on that day), days 3, 6, 9 = Period 2 , days 12, 15...39 = Period 3. Semen was cryopreserved on each day of collection until morphological abnormalities of sperm increased to >50%. Semen …
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Métodos iterativos aplicados a la ecuación de Kepler
… the cycles are characterized superatractives of period 2, which appear when applying Newton's method to the Kepler's equation, and ended with the characterization of the values of eccentricity, for which, semilocal convergence theories of Kantorovich, Gutierrez, Smale and Wang-Zhao, ensure …
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Crosstalk Signaling Between Circadian Clock Components and Iron Metabolism
… iron homeostasis. Then, we measured changes in period, phase, and amplitude of these rhythms, ultimately using a luciferase reporter cell line to demonstrate that even slight changes in cellular iron produce an effect on rhythmic period. We find that the circadian clock and iron metabolism …
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Cytomegalovirus retinitis at Groote Schuur Hospital : clinical management and outcomes
… at Groote Schuur Hospital over a 10 year period 2. To review and compare the treatment protocols of thirteen public hospital centres in South Africa that treat patients for CMV retinitis Design & method This is a retrospective cohort study. A record review of 141 eyes in 91 patients …
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Isoquinoline alkaloids in diets for young growing pigs improve nutrient digestibility and gut health
… and ileal digesta were collected on d 13 and 14 (period 1) and d 26 and 27 (period 2). Results indicated that dietary inclusion of IQ resulted in a quadratic increase (P < 0.05) in the AID of starch, Thr, Trp, Val, Pro, and Tyr in period 1. Additionally, the AID of starch was greater (P < 0.05) in …
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Pairing and entanglement: quantum Monte Carlo studies
… used to model homonuclear diatomic molecules of period-2 elements. The degree of entanglement and the responsible electronic configurations in real space are quantified in terms of the entanglement spectra. Calculating the reduced denstity matrix as an intermediate step reveals a novel way of …
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Interlocking mechanisms regulating the circadian clock response to DNA damage
… time-keeping system that oscillates with a periodicity of about 24 h, namely the circadian clock, that help them adapt to daily environmental changes. Mammalian circadian rhythms are generated and maintained by transcription-translation feedback loops (TTFLs) and include post-translational …
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Actin's role in signaling light-induced phase shifts in the mammalian circadian clock
… results in up-regulation of the clock genes, Period 1 and Period 2. This induction is mediated in part via CRE elements, through activation of the transcription factor, CREB. Connecting upstream signaling processes with the end result of transcriptional changes was a target of this study. …
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An exploratory analysis of the restaurant dining patterns of older adults
… (1) type of restaurant patronized for each meal period; (2) frequency of restaurant visits per meal period; (3) dollar value of purchases per meal period; and (4) restaurant dining companions. A mail survey of 1000 adults age 65 and older, was conducted in order to obtain information about the …
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The legal history of teacher certification in the Commonwealth of Virginia
… This research was structured within ten time periods beginning with the colonial period of Virginia through the present. An organized search was conducted to locate and analyze the historical documents that pertained to the topic. Conclusions From this study, the following conclusions were …
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Circadian modulation of the estrogen receptor alpha transcription
… disorders (e.g. jet lag, insomnia, and cancer). Period 2 (Per2), a circadian protein, is at the center of the clock's function. The loss or deregulation of per2 has been shown to be common in several types of cancer including breast and ovarian [1, 2]. Epidemiological studies established a …
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A decision tree framework for assessing status of exploited marine ecosystems under changing environmental conditions
… trends. Data series were divided into distinct periods based on known environmental changes or shifts within ecosystems. Careful consideration was given as to whether fishing and environmental indicator trends could explain the observed trends in ecological indicators. A method of score …
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Dynamics of Cubic Rational Maps Under Certain Constraints on Critical Points
… a map in the first class having a Herman ring of period 1, but no map in this class has a Herman ring of period ≥ 2.</p> <p>2. Those maps in the first class without Herman rings have only two types of Julia set: either connected or a semi-Cantor set.</p> <p>3. Any map in the second class cannot …
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Laparoscopic Resection of Gastric Submucosal Tumors: Outcomes of 141 Consecutive Cases in a Single Center
… after the 70th case. During the follow-up period, 2 patients suffered recurrent GIST. Laparoscopic surgery for gastric SMT is safe and feasible, particularly as the surgeon develops greater skill with increased experience. Laparoscopic resection is useful for any type of gastric SMT.
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A study of demand deposits, time and savings accounts and loan demand in selected unit F.D.I.C. banks of Montgomery County, Virginia, 1956-1966
… has played such a minor role during the time period; (2) the Radford Arsenal's production has played a stabilizing role in the county, especially since the early 1960s, and; (3) the continuing steady growth of the economy of the Fifth District has had an important effect upon the economy of …
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Politeness in Shakespeare
… the best information on colloquial speech of the period; (2) the psychological soliloquies in the tragedies provide the access to inner life that is necessary for a proper test of politeness theory; and (3) the tragedies represent the full range of society in a period of high relevance to …
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