Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Perinexus"”.
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The role of the perinexus in Long QT Syndrome Type 3
… phenotype can be exacerbated by expanding the perinexus, which is an intercellular nanodomain with high density of Nav1.5 in the intercalated disc. Following this finding, we found that elevating extracellular sodium and widening the perinexus synergistically exacerbated LQT3 phenotype, …
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The Relationship between Ephaptic Coupling and Excitability in Ventricular Myocardium
… expressed in the intercalated disc within the perinexus, which is two orders of magnitude narrower than bulk extracellular interstitium. The biphasic relationship between conduction and perinexus is well-researched and consistent between computations models. We hypothesized a biphasic …
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Extracellular Spaces and Cardiac Conduction
… cellular coupling mechanism: the GJ-adjacent perinexus, with three specific aims. First, I identified the perinexus – a recently-established structure in rodent myocardium – in human atrial tissue. I also observed a significant tendency for open-heart surgery patients with pre-operative atrial …
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Sex Differences in Cardiac Electrophysiology
… rely on gap junctions, sodium channels and the perinexus. When conduction is disrupted it causes arrhythmias. When investigating these three critical determinants of cardiac conduction in guinea pig hearts, we determined that there are sex differences in two of three investigated determinants. …
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Interplay between Ephaptic and Gap Junctional Coupling in Cardiac Conduction
… and this was associated with widening of the perinexus (reduced EpC). Increasing extracellular calcium restored CV to control values by improving not only EpC but also GJC. Finally, in a model of metabolic ischemia in the heart, CV response due to solutions with varying sodium and calcium …
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Single channel studies on the modulation of connexin hemichannels by Cx43 targeting peptides and cytoplasmic Ca2+ in the context of heart disease
… in the periphery of gap junction plaques termed ‘perinexus’, these unapposed hemichannels are typically closed under control conditions, but may open in response to ischemic insults. Uncontrolled activation of hemichannels provides a nonselective conduit between the cytoplasm and extracellular …
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Sodium Channel Loss of Function Sensitizes Conduction to Changes in Extracellular Sodium Concentration
Sudden cardiac death is largely attributable to sudden onset ventricular arrhythmias. Alterations in cardiac conduction, particularly the slowing of conduction velocity is one major factor in arrhythmogenesis. By understanding the mechanisms and factors that modulate cardiac conduction velocity, we …