Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 59 for “"Pericytes"”.
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Pericytes in Early Vascular Development
… are joined by specialized partner cells called pericytes that help guide and mature vessel growth. Pericytes lie elongated along endothelial cells and have multiple points of contact with the endothelium. In this position, pericytes assist in cell-cell communication and even blood flow …
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Role of pericytes in the barrier task
… of PCs and examines the effects of hASC like-pericytes on human retinal endothelial cells (hRECs) for barrier formation by measuring trans-endothelial electric resistance and by immuno-analysis. Therefore, adipose stem cells-based therapeutic approaches may be usefully exploited to restore …
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Mechanisms of amyloid B-induced cell death in human brain pericytes. Identification of potential inhibitors and mediators.
Contains fulltext : 146965.pdf (Publisher’s version ) (Open Access)
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PERICYTE SUBTYPES AT THE INTERSECTION BETWEEN TISSUE REGENERATION AND PATHOLOGY
… and can lead to organ failure. Cells called pericytes, located around blood vessels, act as stem cells. Some studies suggest that pericytes may contribute to regeneration in various organs as well as fibrous tissue and fat formation in response to aging and pathologies. Based on markers and …
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Development of a pericyte-based strategy to recover aged skeletal muscle after disuse
… perivascular stem cells (NG2+ and CD146+ pericytes), also considered the primary mesenchymal stem cell (MSC) in muscle, can effectively recover muscle mass in young adult mice following a period of immobilization. However, several questions remained after the completion of this study. What …
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The Effect of Ischemia and High-Fat Diet on Pericyte Fate
… fat (HF) diet and ischemia on skeletal muscle pericytes. Pericytes are mural cells on the abluminal surface of capillaries that contribute to capillary stabilization and the regulation of angiogenesis, but their roles in the events that occur during muscle recovery from ischemia in patients …
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Perivascular cell contribution to skeletal muscle repair following physiological injury
… stromal cells, including but not limited to, pericytes, fibroadipogenic progenitor cells, and smooth muscle cells. Therefore, the purpose of this study was to examine the specific contribution of muscle-derived pericytes (CD146+CD45-CD31- or CD146+Lin-) to skeletal muscle repair following …
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Investigating the integrity of the vasculature and structural relationships of pericytes, astrocytes and the endothelial glycocalyx in an ex vivo hyperglycaemic rat retinal model
… components of the BRB include endothelial cells, pericytes and the glial cells (mainly astrocytes), which together maintain the integrity and barrier function of the retinal vasculature. However, there is limited data regarding the interconnecting biochemical pathways that lead to pericyte loss, …
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Pericyte deficiencies in a foxf2 loss of function mutant
Pericytes are critical players in vascular development and disease but are not widely studied in the context of cerebral small vessel disease, a vascular condition related to stroke that progressively weakens brain microvessels. Foxf2, a pericyte-expressed gene, is involved in vascular stability …
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Insulin Resistance and Inflammation in Neurodegeneration: Lessons from in vitro Models
… of IR and chronic inflammation in neurons and pericytes that line the BBB. A chronic insulin model of insulin resistance in differentiated human neurons was developed to examine changes in gene expression associated with an insulin resistant state. Microarray analysis revealed altered …
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Skeletal muscle pericyte response to acute and chronic electrical stimulation
Pericytes are mural cells that are located on the outer surface of blood capillaries where they attach to endothelial cells and regulate vascular function, including dilation and angiogenesis. Recent studies suggest that pericytes in skeletal muscle may contribute to myofiber repair in response to …
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Notch deficiency leads to arteriovenous malformations and altered pericyte function
… sprout from pre-existing vasculature and recruit pericytes to induce maturation and vessel quiescence. Perictyes are associated with small vessels and capillaries where they share the basement membrane with the endothelium to provide vascular support. Pericytes are a critical component of the …
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Adult Neural Stem Cells and Their Perivascular Niche
… neural stem cell lineage. Moreover, the role of pericytes in the SVZ stem cell niche has not been defined. Here we describe a FACS methodology to isolate pure, primary endothelial cells and pericytes from neurogenic and non-neurogenic brain regions and perform studies in vitro to examine their …
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Optimization of a pericyte therapy to improve muscle recovery following hindlimb immobilization
… myofiber size in mice. These data suggest that pericytes positively influence skeletal muscle growth and may represent a novel approach to the prevention and treatment of disability following disuse. However, one of the challenges in developing a pericyte therapy is the lack of a unique marker …
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Regulation of Lung Mesenchymal Cells By Epithelial Wnt Ligands
… we also found that myofibroblasts and pericytes experience canonical Wnt signaling. We know that the alveolar type 1 (AT1) epithelial cell signals via Vascular Endothelial Growth Factor A towards the lung vasculature. Given the large surface area of the AT1 cell, we hypothesized they …
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Pericyte and Endothelial Cell Responses within Murine Cerebral Capillaries After Blood Flow Cessation
… microcirculation, and investigates the role of pericytes in maintaining blood-brain barrier (BBB) integrity and neurovascular homeostasis. In this work We highlighted the dynamic interactions between pericytes, endothelial cells, and the extracellular matrix (ECM) in the regulation of …
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Stromal Derived Growth Factor Alpha (Sdf-1Α) Induces The Differentiation of Bone Marrow Progenitor Cells (Bmcs) Into Pericytes By Regulating Platelet Derived Growth Factor B (Pdgf-B) Transcription
… differentiate into endothelial cells (ECs) and pericytes and, participate in the tumor vascular development. This process of neo-vascularization, known as vasculogenesis, is essential for Ewing’s sarcoma growth with the soluble vascular endothelial growth factor, VEGF<sub>165</sub>, being the …
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Blood-brain barrier model on a microfluidic chip for the study of tumor cell extravasation
… cells, coupled with the spatial organization of pericytes and astrocytes around the vasculature, restrict the entry of most solutes and cells into the brain. Yet, the brain constitutes a common metastatic site to many primary cancers originating from the lung, breast and skin. This suggests that …
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Characterisation of a Novel GABA Signalling System in the Human Cerebral Vasculature
… and in vitro in cultures of human primary MTG pericytes and human cerebral microvascular endothelial cells (hCMVECs), revealing the existence of a unique repertoire of GABAA receptor subunits as well as GABAB receptor subunits and potentially GABA transporters. NanoString nCounter analysis was …
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Development of a stem cell-based therapy for the recovery of skeletal muscle mass following immobilization
… Perivascular stem/stromal cells, including pericytes, reside in close proximity to microvessels, possess myogenic capacity, and secrete various regenerative paracrine factors, making them ideal candidates for stem cell-based therapies. However, minimal information exists regarding their …
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