Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"Perforin-2"”.
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Deciphering the regulation of perforin-2-mediated endocytic escape in dendritic cells
… lab had identified the pore-forming protein perforin-2 as a dedicated effector of endocytic escape that allows cytosolic entry of exogenous antigen during cross-presentation. Perforin-2 is a member of the membrane attack complex and perforin superfamily (MACPF) and, similar to perforin and …
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Characterization of endocytic escape pathway and its role in adaptive immunity
… yielded one strong hit: pore-forming protein, perforin-2 (*Mpeg1*; Macrophage-expressed gene 1) and we proposed perforin-2 forms pores in endolysosomal compartments, allowing for endocytic escape of saporin. The main aim of my PhD was to extend our understanding of mechanisms governing …