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Showing 1 to 20 of 52 for “"Perforin"”.

  1. Einfluß körperlicher Ausdauerbelastung auf Perforin und Granzyme-B exprimierende Lymphozytenpopulationen

    Uhl, Dieter

    … der Lymphozytensubpopulationen beteiligt. <br>Perforin und GrB sind zwei wichtige Proteine in Ablauf zytotoxischer Mechanismen von NK-Zellen und CTL. Ausdauersportler in Ruhe weisen im Vergleich zu nicht Sport treibenden Personen einen höheren Anteil an Zellen mit intrazellulären Gehalt dieser …

    freiburg-diss Repository record

  2. The role of the cytolytic mediators, granulysin and perforin, in tuberculosis

    Semple, Patricia LynnDivision of Clinical Immunology2008

    … cells. Granulysin, an antimicrobial protein, and perforin, a pore-forming molecule, have been found to co-localise in the granules of these two cell types. Granulysin has been shown to be directly cytotoxic to extracellular Mycobacterium tuberculosis (M.tb) and, together with perforin, is …

    cape-town Repository record

  3. Deciphering the regulation of perforin-2-mediated endocytic escape in dendritic cells

    Laub, MarcoUniversity of Cambridge2024

    … lab had identified the pore-forming protein perforin-2 as a dedicated effector of endocytic escape that allows cytosolic entry of exogenous antigen during cross-presentation. Perforin-2 is a member of the membrane attack complex and perforin superfamily (MACPF) and, similar to perforin and …

    cambridge Repository record

  4. Role of CD44, Fas Ligand, and Perforin in the Cytotoxicity Mediated by Natural Killer Cells

    Bradley, Michael JosephVirginia Tech1997

    … of lymphocyte-mediated cytotoxicity, one perforin based and the other Fas ligand (FasL) based, have been characterized recently. It has also been shown that CD44, an adhesion molecule, can participate in signaling cytotoxic activity of cytotoxic T lymphocytes (CTLs). In the current study …

    vt Repository record

  5. Cholesterol-Dependent Cytolysins and Perforin: Similar Pore-Forming Mechanisms in Pathogenic Attack and Human Immune Defense

    Marchioretto, MartaUniversità degli studi di Trento2013

    … O and Listeriolysin O, and on the human protein Perforin, which is involved in the apoptotic pathway facilitating Granzyme release. In the literature, two possible configurations of CDCs and Perforin pores are proposed: ring and arc structures that could have different implications on the …

    trento Repository record

  6. Expression of perforin and granzyme variants in adult rat testes after ethylene dimethane sulfonate (EDS)-induced testosterone depletion

    Dutta, DibyenduTexas Woman's University2011

    … the relationship between granzyme and perforin, and germ cell apoptosis. To confirm effects of testosterone depletion, EDS-treated rats were compared with testosterone-replaced and testosterone-supplemented rats. At 5 and 7 days post-EDS treatment, rats were euthanized for tissue …

    twu Repository record

  7. Die Bedeutung von Granzym A, B, K und Perforin bei gesunden Personen und in der Pathogenese chronischer Lungenerkrankungen

    Boettcher, Heidrun Elise

    … Induktion von Apoptose sind sie gemeinsam mit Perforin bei der Abwehr von Infektionen, Tumorzellen, transplantiertem Fremdgewebe und bei Autoimmunerkrankungen bedeutsam. Bisher sind beim Menschen fünf Granzyme charakterisiert worden. Während über Granzym A und B bereits viel geforscht wurde, …

    freiburg-diss Repository record

  8. Granzyme B- und Perforin-positive Lymphozyten in der bronchoalveolären Lavage und dem perpheren Blut bei Patienten mit Asthma bronchiale

    Abd-el-Ghani, Steffen

    … dann wurde intrazellulär Granzyme B bzw. Perforin mit Antikörper markiert. Gemessen wurde mittels FACS. Weiterhin wurden die Veränderungen nach Kultivierung oder Stimulation mit PMA und Ca-Ionophore bzw mit anti-CD3 bestimmt.

    freiburg-diss Repository record

  9. Evaluation of granulysin and perforin as candidate biomarkers for protection following vaccination with Mycobacterium bovis BCG or M. bovis DeltaRD1

    Charles Fernando Capinos SchererThe University of Texas Medical Branch2008

    … antimicrobial protein granulysin (Bo-lysin) and perforin by our group could be used as potential biomarkers for TB vaccination efficacy. In the present study we examined the kinetics of granulysin, perforin, IFNgamma and Fas-L responses to Mycobacterium bovis purified protein derivative (PPD) …

    utmb Repository record

  10. Untersuchung zur Funktion von Cathepsin B in der durch zytotoxische T-Zellen vermittelten Lyse von Tumorzellen

    Ensslen, Miriam2012

    … (CTL) sich selbst vor der Lyse durch ihr eigenes Perforin mittels Expression von Cathepsin B auf der Zelloberfläche schützen. Interessanterweise wird Cathepsin B auch in vielen Tumorzellen vermehrt exprimiert und ist möglicherweise in die Tumorprogression involviert. Dies veranlasste uns zu …

    goettingen Repository record

  11. The Role of Serine Protease Inhibitors in Regulating Hepatotoxicity During Viral Infection

    Stout-Delgado, Heather Winona2010

    … and malignant cells by two major pathways, the perforin/granzyme pathway and the Fas and/or TNF death receptor pathways. In contrast to other target cells, virally infected hepatocytes are resistant to killing by perforin and granzyme-dependent cytotoxic effector pathways. This results in a more …

    utswmed Repository record

  12. Effector CD4+ T lymphocyte resolution of acute HSV infection at genital and neuronal sites, and the manipulation of CD4+ T cell responses via TLR ligand-induced proinflammatory cytokine milieus

    Alison Joy JohnsonThe University of Texas Medical Branch2010

    … significantly different in CD8+ T-cell-depleted, perforin-deficient or FasL-defective mice compared to wild-type mice. Virus titers in neural tissues of chimeric mice expressing both perforin and Fas or neither perforin nor Fas were significantly lower than in controls. Thus, perforin and Fas were …

    utmb Repository record

  13. Mechanismen der CD8+ T-Zell-vermittelten Tumorabwehr beim B16 Melanom der Maus

    Neuenhahn, Michael

    … wurden CD8+ T?Effektorzellen aus Perforin (P°)-, Interferon-g (IFN°)-, und TNF-a (TNF°)-defizienten TCR tg Mäusen in Mäuse mit etablierten Metastasen transferiert. Während nach Transfer von TCR tg-P° und TCR tg-TNF° T-Effektorzellen sowohl in immunkompetenten als auch in Perforin- …

    freiburg-diss Repository record

  14. Characterization of endocytic escape pathway and its role in adaptive immunity

    Krawczyk, Patrycja AnnaUniversity of Cambridge2023

    … yielded one strong hit: pore-forming protein, perforin-2 (*Mpeg1*; Macrophage-expressed gene 1) and we proposed perforin-2 forms pores in endolysosomal compartments, allowing for endocytic escape of saporin. The main aim of my PhD was to extend our understanding of mechanisms governing …

    cambridge Repository record

  15. Experimental Models of Mycobacterial Replication and Killing in Macrophages

    Laochumroonvorapong, Pairote

    … that both apoptosis [Fas-mediated] and necrosis [perforin-induced] of infected human monocytes do not affect the survival of intracellular mycobacteria in an in vitro infection model. To determine the role of apoptosis and necrosis on mycobacterial infection in vivo, perforin gene-disrupted mice …

    rockefeller Repository record

  16. Die Bedeutung zytotoxischer Effektormoleküle bei der ConA induzierten Hepatitis

    Grosse, Philipp

    … mehreren Effektormolekülen von ZTL, insbesondere Perforin, GzmA, GzmB, FasL und Fas, wurde in dieser Arbeit die molekulare Basis der pathologischen Vorgänge näher charakterisiert.

    freiburg-diss Repository record

  17. Tumor cell-immune cell interaction: A lethal two way street

    Zeytun, AhmetVirginia Tech1999

    … To determine the role of the Fas, FasL, and perforin in the initiation of tumor, C57BL/6 +/+ (FasL+, Fas+), C57BL/6 lpr/lpr (Fas-), C57BL/6 gld/gld (FasL-), and perforin knock-out (PKO) (FasL+, Fas+, but perforin-deficient) mice were injected with methylcholanthrane (MCA). Tumor development …

    vt Repository record

  18. Role of CD44 in Immune Functions and Endothelial Cell Injury

    Rafi-Janajreh, AsimahVirginia Tech1998

    … following IL-2 administration. Interestingly, perforin-knockout mice exhibited marked decrease in VLS in all three organs tested. Also, FasL-defective (gld) mice and Fas-deficient (lpr) mice exhibited decreased VLS in the liver and spleen, but not in the lungs. These results demonstrated for …

    vt Repository record

  19. Human Complement Protein C8: Crystal Structure and Analysis of Binding Interactions

    Cooper, Christopher Langston

    … segment referred to the membrane attack complex/perforin (MACPF) domain. The role of C8 within the MAC is to initiate formation of a transmembrane pore consisting of 12-18 molecules of C9.

    south-carolina Repository record

  20. Characterization of Differentiation and Prognostic Biomarkers On Cd8+ Tumor-Infiltrating Lymphocytes In Metastatic Melanoma

    Wu, Richard C2013

    … express another cytolytic pore-forming molecule, perforin (Perf). In contrast, the CD8<sup>+</sup>CD57<sup>+</sup> T cells in the periphery were CD27<sup>-</sup>CD28<sup>-</sup>, and GB<sup>Hi</sup> and Perf<sup>Hi</sup>. We found this TIL subset was not senescent and could be induced to …

    uthsc Repository record

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