Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 11 of 11 for “"Percutaneous absorption"”.
-
The percutaneous absorption of ionisable compounds
… were investigated in vitro using Franz-type absorption cells. Suspensions and solutions of salicylic acid (SA), the model ionogenic permeant, were used as donors and the variables studied were vehicle pH and trans-membrane pH-gradients. For solutions, the pH effect was related to the level of …
-
Chemical and physical methods of enhancing the percutaneous absorption of antimicrobial agents
… of supersaturated solutions in enhancing percutaneous absorption of CHX was investigated. Various anti-nucleating polymers were screened in order to establish the most effective agent. Polyvinylpyrrolidone (PVP, K30) was found to be a better candidate than its lower molecular weight …
-
Formulation and preparation of niosomes containing bioactive compounds
… into niosomes and liposomes and its ex-vivo percutaneous absorption in newborn pig skin was investigated using Franz diffusion cells. Cholesterol was also added as membrane stabilizer. The influence of vesicle composition on its physicochemical properties and stability was evaluated. …
-
The damaging potential of pesticide formulations on human skin
Percutaneous absorption is the major route of pesticide entry into the body. Impairment of skin barrier function may increase systemic exposure and toxicological risk. This project examines barrier function impairment of human skin in vitro due to commercial liquid formulations of the pesticides …
-
Mechanisms of chemical and physical transdermal penetration enhancement
… the processes involved in the enhancement of percutaneous absorption. The development of an attenuated total reflectance Fourier-Transform infrared (ATR-FTIR) spectroscopic method to analyse diffusion of suitable topically applied compounds in membrane is described. Diffusion coefficients …
-
Studies on the Formulation of Topical Corticosteroids
… of about one year were formulated. The percutaneous absorption of hydrocortisone and its 17- and 21-butyrates and 21-acetate were studied using three in vitro models which enabled simultaneous monitoring of more than one steroid. The studies included release from Carbopol gel into …
-
Synthesis and design of ligand copper complexes as anti-inflammatory drugs
… test new ligands which are able to promote the percutaneous absorption of copper and/or mobilize endogenous copper reserves. Formation constants of H+, Cu(II), Ni(II) and Zn(II) with five low molecular ligands 2-((2-aminoethyl)amino)-N-(pyridin-2- ylmethyl)acetamide) [H(555)NH2], …
-
A novel encapsulation favorably modifies the skin disposition of topically-applied N,N-diethyl-3-methylbenzamide (DEET)
… microcapsule facilitated a decrease in skin absorption compared to a DEET in ethanol control while evaporation rates were maintained. Although DEET is considered to be a safe active in topical formulations, it is important to minimize skin absorption in order to retain the material on the …
-
Critical Quality Attributes of Topical Semi-solid Dosage Forms: Solvent Activity
Critical quality attribute has been defined as “a physical, chemical, biological or microbiological property or characteristic that should be within an appropriate limit, range, or distribution to ensure the desired product quality”. Deviations from preset quality metrics may potentially result in …