Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Peptoids"”.
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Designing Amphiphilic Peptoids for Controlling the Formation of Nanostructured Biomimetic Materials
… molecular design and limit broader applications. Peptoids, or poly-N-substituted glycines, are a versatile class of peptide mimetics that mimic the sequence tunability while offering unique advantages, including resistance to degradation, environmental stability, and ease of synthesis. With …
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Design and Synthesis of Nanostructured Peptoids Assemblies that Mimic Natural Carbonic Anhydrases
… CA mimics and achieve high catalytic efficiency. Peptoids, poly-N-substituted glycines, offer unique advantages for this purpose because they can self-assemble into various nanostructures with high crystallinity and stability and serve as the template for precise control over the active sites that …
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Synthesis and Chromatography of [RuCp]+-labelled Diaryl Ether Peptoids as Precursors of the Bastadins from the Marine Sponge Ianthella basta
… bonds. The synthesis of the ruthenium-labelled peptoids in this thesis uses the nucleophilic attack of phenolates on [RuCp]+-complexed chloroarenes to form diaryl ethers in the preparation of metal-labelled bastadin model compounds. The purification and characterisation of [RuCp]+-labelled …
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New Approaches to the Development of Peptoid Vaccines
… of mimetic B cell epitopes. For this platform, peptoids were chosen to construct one-bead-one-compound libraries. Peptoids are N-oligosubstituted glycines that resemble peptides but bear their side groups on backbone nitrogens instead of carbons. This renders them protease resistant and …
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Chemical Genetic Studies of Tumor Suppressors in the Developing Zebrafish
… zebrafish to study cancer involve a screen using peptoids. The peptoid is a class of compound that is modular, easy and inexpensive to synthesize, and stable in vivo. Initial tests reveal that peptoids are able to enter the zebrafish embryo, remain stable, and exert biological functions. Screening …
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Sequence and structural effects on molecular conductance of bioinspired peptoid oligomers
… control over sequence and structure are peptoids or N-substituted polyglycines. The sequence-defined modularity of peptoids enables precise control over their structure–function relationships, enabling potential materials applications in energy storage, energy conversion, and biomedical …
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NOVEL PEPTOID TARGETING CELL SURFACE VIMENTIN FOR LUNG CANCER TREATMENT
Peptoids are an emerging class of peptidomimetics that received much attention in recent times due to their drug-like properties. In comparison to conventional peptide and antibody therapeutics, peptoids exhibit improved serum and chemical stability, tissue and cell permeability, and reduced …
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Controlling Gene Expression with Synthetic Molecules
… of large peptoid libraries has been developed. Peptoids are a new class of peptidomimetic compounds that are resistant to proteolytic cleavage and are relatively simple and cheap to synthesize. One of the combinatorial libraries was screened against CBP (CREB-binding protein), an important …
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Directing the Mineralization of Inorganic Nanomaterials using Programmable Macromolecular Building Blocks
… building blocks such as peptides, proteins, and peptoids offer a path toward the construction of precision materials by enabling the organization, mineralization and dynamic reconfiguration of organic and inorganic components through engineered functions. With thermoresponsive elastin-like …
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A Novel Platform to Generate Synthetic Vaccine Candidates
… monoclonal antibodies (MAbs) to select the peptoids that bound to the antibody’s antigen-combining site, and 3) protein G dynabeads (PGDs) and a magnet to bind and isolate antibody bound peptoid beads. Any sequences identified in the platform as potential B cell mimetics were further …
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Part I: Steroid Receptor CO-Activator 3 (SRC-3) Expression in Lung Cancer and its Role in Regulating Cancer Cell Survival and Proliferation; Part II: Development of Phosphospecific Peptoid Ligand
… identified by screening a library of 40,000 peptoids for PDID binders. The isolated hit peptoids are only specific to phos-PDID, but not the non-phosphorylated form of the protein, or other phosphoserine- or phosphothreonine-containing proteins. Phos-PDID-binding peptoids can specifically …
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Part 1: Isolation of Orexin Receptor Regulators via a Microarray-Based,Two-Color Cell Binding Screen. Part II: Targeted Inactivation of Proteins triggered by Visible Light.
… new orexin receptor ligands. We found that peptoids on microarray, which showed preferential binding to receptor-expressing cells, indeed regulate the function of the receptor in living cells. Although cell-adhesion peptide microarrays have been used to isolate peptides that bind to cell …
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Biomarker Discovery in Autoimmune Diseases: A Proteomics Approach
… a high-throughput study is reported showing that peptoids are, in general, a relatively more cell permeable class of molecules than peptides, rendering them ideal for drug development to target disease biomarkers.
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A Novel Interleukin-15 Receptor Antagonist for the Treatment of Rheumatoid Arthritis
… by selectively binding to its receptor, IL-15Rα. Peptoids offer several advantages over peptides, such as increased stability, enhanced bioavailability, and reduced immunogenicity, making IFRA3Q1 a promising therapeutic candidate. The primary objectives of this research are to validate IFRA3Q1’s …
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Discovery of Molecules that Modulate Protein-Protein Interactions in the Context of Human Proliferating Cell Nuclear Antigen-Associated Processes of DNA Replication and Damage Repair
Integral to cell viability is the homotrimeric protein complex Proliferating Cell Nuclear Antigen (PCNA) that encircles chromatin-bound DNA and functionally acts as a DNA clamp that provides topological sites for recruitment of proteins necessary for DNA replication and damage repair. PCNA has …