Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"Peptoid"”.
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New Approaches to the Development of Peptoid Vaccines
… of mimetic B cell epitopes. For this platform, peptoids were chosen to construct one-bead-one-compound libraries. Peptoids are N-oligosubstituted glycines that resemble peptides but bear their side groups on backbone nitrogens instead of carbons. This renders them protease resistant and …
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NOVEL PEPTOID TARGETING CELL SURFACE VIMENTIN FOR LUNG CANCER TREATMENT
Peptoids are an emerging class of peptidomimetics that received much attention in recent times due to their drug-like properties. In comparison to conventional peptide and antibody therapeutics, peptoids exhibit improved serum and chemical stability, tissue and cell permeability, and reduced …
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Sequence and structural effects on molecular conductance of bioinspired peptoid oligomers
… control over sequence and structure are peptoids or N-substituted polyglycines. The sequence-defined modularity of peptoids enables precise control over their structure–function relationships, enabling potential materials applications in energy storage, energy conversion, and biomedical …
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Design of Nanostructured Peptoid Assemblies as Synthetic Analogues of Natural Carbonic Anhydrases
… of metal-ligand active sites into nanostructured peptoid materials. We further assessed their CA mimic performance under different conditions. Our results show that metal-containing peptoid nanosheet materials are effective as CA mimics, which makes them suitable candidates for bioinspired carbon …
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A Novel Platform to Generate Synthetic Vaccine Candidates
… cell epitopes or “shapes” prepared by displaying peptoid sequences on beads, 2) neutralizing monoclonal antibodies (MAbs) to select the peptoids that bound to the antibody’s antigen-combining site, and 3) protein G dynabeads (PGDs) and a magnet to bind and isolate antibody bound peptoid beads. Any …
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Influence of Extracellular Matrix Stiffness and Topography on Neuronal Cell Behavior and Neurite Outgrowth
… the neuronal cell.</p> <p>Next, we investigate peptoid as an ECM ligand, as it is gaining popularity due to its biocompatibility, self-assembling structure, and neurodegenerative therapeutic potential, but the peptoid interaction with neuronal cell receptors for mechanosensing need to be …
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Design and Synthesis of Nanostructured Peptoids Assemblies that Mimic Natural Carbonic Anhydrases
… CA mimics and achieve high catalytic efficiency. Peptoids, poly-N-substituted glycines, offer unique advantages for this purpose because they can self-assemble into various nanostructures with high crystallinity and stability and serve as the template for precise control over the active sites that …
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Part I: Steroid Receptor CO-Activator 3 (SRC-3) Expression in Lung Cancer and its Role in Regulating Cancer Cell Survival and Proliferation; Part II: Development of Phosphospecific Peptoid Ligand
… cancer. PART II: DEVELOPMENT OF PHOSPHOSPECIFIC PEPTOID LIGAND Most proteins can exist in a variety of post-translationally modified forms. Chemical methods that would allow one to specifically purify or pharmacologically target a particular form of the protein would be of great interest. Here, …
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Designing Amphiphilic Peptoids for Controlling the Formation of Nanostructured Biomimetic Materials
… molecular design and limit broader applications. Peptoids, or poly-N-substituted glycines, are a versatile class of peptide mimetics that mimic the sequence tunability while offering unique advantages, including resistance to degradation, environmental stability, and ease of synthesis. With …
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Part 1: Isolation of Orexin Receptor Regulators via a Microarray-Based,Two-Color Cell Binding Screen. Part II: Targeted Inactivation of Proteins triggered by Visible Light.
… have developed a novel two-color, cell-binding peptoid microarray screening approach with which we discovered new orexin receptor ligands. We found that peptoids on microarray, which showed preferential binding to receptor-expressing cells, indeed regulate the function of the receptor in living …
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Controlling Gene Expression with Synthetic Molecules
… screening and characterization of large peptoid libraries has been developed. Peptoids are a new class of peptidomimetic compounds that are resistant to proteolytic cleavage and are relatively simple and cheap to synthesize. One of the combinatorial libraries was screened against CBP …
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Discovery of Molecules that Modulate Protein-Protein Interactions in the Context of Human Proliferating Cell Nuclear Antigen-Associated Processes of DNA Replication and Damage Repair
… the selection and subsequent synthesis of tripeptoid ligands, which were evaluated in a PCNA-based competitive displacement assay. From the results, some of the peptoid-based compounds that were synthesized displayed the ability to disrupt the interaction between PCNA and a PIP box-containing …
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Synthesis and Chromatography of [RuCp]+-labelled Diaryl Ether Peptoids as Precursors of the Bastadins from the Marine Sponge Ianthella basta
… bonds. The synthesis of the ruthenium-labelled peptoids in this thesis uses the nucleophilic attack of phenolates on [RuCp]+-complexed chloroarenes to form diaryl ethers in the preparation of metal-labelled bastadin model compounds. The purification and characterisation of [RuCp]+-labelled …
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Chemical Genetic Studies of Tumor Suppressors in the Developing Zebrafish
… zebrafish to study cancer involve a screen using peptoids. The peptoid is a class of compound that is modular, easy and inexpensive to synthesize, and stable in vivo. Initial tests reveal that peptoids are able to enter the zebrafish embryo, remain stable, and exert biological functions. Screening …
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Novel Poly(N-substituted glycine)s : synthesis, post-modification, and physical properties
… glycine) homo/co-polymers (a.k.a. polypeptoids). In particular, monomers that would facilitate in the preparation of bio-relevant polymers via either chain- or step-growth polymerization were targeted. A 3-step synthetic approach towards N-substituted glycine N-carboxyanhydrides (NNCA) …
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A Novel Interleukin-15 Receptor Antagonist for the Treatment of Rheumatoid Arthritis
… study explores the potential of IFRA3Q1, a novel peptoid antagonist, designed to inhibit IL-15 by selectively binding to its receptor, IL-15Rα. Peptoids offer several advantages over peptides, such as increased stability, enhanced bioavailability, and reduced immunogenicity, making IFRA3Q1 a …