Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Peptide-drug conjugate"”.
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The Development of a Novel Peptide-Drug Conjugate for Treating Triple-Negative Breast Cancer
… like hormone therapies and targeted HER2 drugs are ineffective. The use of chemotherapies in treating TNBC is an effective option instead. However, chemotherapies are not selective, thus they cause severe side effects such as cardiotoxicity, myelosuppression, alopecia and gastrointestinal …
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The Development of a Cancer-Targeting Peptide-Drug Conjugate for the Treatment of Melanoma
… to over 2 years as a result of this concerted drug development effort; however, this rapid development of treatment technologies come with new severe adverse effects, as well as increased opportunity for toxicity and drug resistance. It is not uncommon for a treatment to switch before …
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Evaluation of Peptides and Peptide–Doxorubicin Conjugates Designed and Synthesized for Targeting Triple-Negative Breast Cancer via Cell-Surface Receptors
… This forms the foundation of ligand-targeted drug delivery. Among different breast cancers, treatment of the triple-negative breast cancer (TNBC) subtype has been particularly challenging, largely due to the absence of a well-defined biomarker to exploit for targeted drug delivery. This has …
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Design and applications of antibody mimics against epidermal growth factor receptor
… a number of monoclonal antibodies and their drug conjugates have been approved as therapeutic agents. While these molecules have great potential in various applications and therapeutics, extensive use of full length antibodies has been hampered by the high cost of production, large molecular …
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Peptide-Based Platform For Cancer Therapeutics And Drug Transportation Across Blood-Brain Barrier
… inadequate availability to the tumor tissue, drug resistance, and the complicated microenvironment in tumor tissues. As a result, there is a great need to develop targeted delivery systems for chemotherapy agents for prostate cancer therapy. One objective of this dissertation is to develop …
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Design and Sythesis of Conjugages of Amphiphilic Cell-Penetrating Peptides Containing Anticancer Drug and Ligand for Extra Cellular Matrix Biomarker to Provide Efficient Tumor-Targeting
<p>Peptide-drug conjugates (PDCs) have emerging applications in the safer delivery of chemotherapeutics to the site of diseases to avoid the side effects associated with the drug. PDCs also improve the physicochemical property of the anticancer drug. Therefore, we have designed and synthesized …
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One-Carbon Bridge Stapling for use in Peptide-Drug Conjugates
One-Carbon Bridge Stapling for use in Peptide-Drug Conjugates Bethany M. Cooper Therapeutic peptides lie in between small molecules and therapeutic proteins in terms of their molecular weight and have many advantageous properties, such as high potency and selectivity. Yet one fundamental …
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Small Molecules and Their Conjugates with Peptides: Chemical Strategies to Tackle Resistant Bacteria
… of the current treatments, release of drugs in a more selective way, or discovery of new compounds and bacterial targets. This thesis will cover two projects that have tried to address the latter two strategies. The first part focuses on a bacterium with robust resistance mechanisms, …
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Amphipathic Hybrid Cyclic-Linear Peptides as a Drug Delivery System
<p>Amphipathic Hybrid Cyclic-Linear Peptides as a Drug Delivery System by Jonathan A. Moreno Peptides</p> <p>[RW]<sub>4</sub> and [R<sub>5</sub>W<sub>4</sub>] have been previously identified as molecular transporter Cell Penetrating Peptide (CPP) and antimicrobial agents, respectively. These …