Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Peptide targeting"”.
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Explainable Machine Learning Prediction of Antimicrobial Peptide Targeting Streptococcus mutans
… learning pipeline to design antimicrobial peptides targeting S. mutans in responsiveness to the acidic conditions of the cariogenic microenvironments. Our explainable ML pipeline approach transforms the targeted peptide design into a data-driven methodology and bridges the explainability …
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Platinum-NGR A Peptide Targeting Conjugate Of Cisplatin: Design, Synthesis, And Efficacy In Breast Cancer Cells
… drug resistances in the body by the addition of targeting moieties specific to cancer cell receptors. In this study we synthesized a platinum-Asn-Gly-Arg (NGR) peptide conjugate with a long-term goal of reducing adverse effects in patients, as well as combating possible drug resistance compared …
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Peptide Targeting of Platinum Anti-Cancer Drug and Synthesis of Water Soluble Monofunctional Pt(II) Complexes Useful for Biological Labeling
… were synthesized having the NGR and LHRH targeting motif. The platinum conjugates bearing the NGR motif revealed selective delivery and destruction of cancer cells that had CD13 receptors compared to untargeted carboplatin drug. The development of targeted chemotherapeutic has opened a new …
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Development of Endoplasmic Reticulum Targeted Probes and Red Fluorescent Probes for Detecting Zinc
… sensors. In this thesis, we use a combination of peptide targeting sequences, site-directed mutagenesis, and rational design to target the currently developed cpFP Zn<sup>2+</sup> sensors to the lumen of the endoplasmic reticulum (ER), and expand the tool kit of cpFP Zn<sup>2+</sup> sensors by …
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Biologically Inspired Design of Protein-Silica Hybrid Nanoparticles for Drug Delivery Applications
… or supramolecular carriers that incorporate targeting ligands and that enable controlled release. The overall aim of this work is to engineer a hybrid nanomaterial system comprised of protein and silica and to characterize its potential as an encapsulating drug carrier. The synthesis of …
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Peptide targeted imaging of neutrophil invasion in cardiac tissue
… to test the efficacy of neutrophil blocking peptides, and provide a foundation for in vivo studies of peptide blocking. Current medical practices address the initial occlusion of heart flow by a surgical technique that re-opens the affected artery. If done early enough, this intervention can …
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Development of an αᵥβ₆-Binding Peptide for In Vivo Applications: Modulation of Serum Stability and Biodistribution
… and treatment of many types of cancers. Peptides are capable of efficient and selective delivery of a variety of cargoes to their target cells and have been in development as targeting ligands for a variety of pathologies for several years. The H2009.1 peptide binds to αᵥβ₆, an integrin …
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Peptide Targeted Drug Delivery to Non-Small Cell Lung Cancer
… treatment. The phage display selected H2009.1 peptide exhibits high affinity for αᵥβ₆, specifically binding and internalizing into αᵥβ₆-expressing cells. Tumor targeting therapies that specifically deliver drugs to the tumor, reducing accumulation and toxicity in non-target tissues, are a …
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The design and synthesis of fluorescent peptides and disaccharides for tumour imaging.
Chapter 1: Peptide targeting of integrin αvβ3 Integrins are cellular surface receptor proteins involved in numerous cellular signalling and adhesion processes. The integrin αvβ3 subtype is up-regulated around sites of malignancy especially solid tumour masses. This is due to its expression on the …
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Improving Cardiac Delivery of Antisense Oligonucleotides with Peptidomimetic Targeting Agents
… kidneys. Our lab has a platform for discovering peptide-protein interactions, affinity selection-mass spectrometry (AS-MS), with which we can find short peptide or peptidomimetic targeting agents with nM binding affinity to target proteins. Here, I describe a platform for selecting and procuring …