Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 12 of 12 for “"Peptide self-assembly"”.
-
Peptide Self-Assembly from the Molecular to the Macroscopic Scale at Standard Conditions
… part of the dissertation focuses on the study of self-assembly as a way to make useful peptide-based materials. There are major efforts underway to study protein self-assembly for various medical and industrial reasons. Despite huge progress, most studies have focused on nanoscale self-assembly …
-
Composition, thermodynamics, and morphology: A multi-scale computational approach for the design of self-assembling peptides
Peptide self-assembly has generated significant interest as a means for the bottom-up fabrication of highly tunable biocompatible nanoaggregates. Individual peptides can be synthesized to include non-natural π-conjugated subunits, endowing assembled aggregates with a range of optical and electronic …
-
Effects of glycosylation on the structure and fibrillization of prion protein fragments
… can play a major role modulating polypeptide conformation. It has also been shown that glycosylation can alter the thermodynamics of disulfide bond formation, favoring oxidation. To address the role of glycosylation on PrP, we have prepared glycosylated and unglycosylated peptides …
-
Amyloid β Aggregation is Coupled to Cellular Metabolism and Intramitochondrial Proteostasis
… age-associated disorders characterised by peptide aggregation, such as Alzheimer's disease (AD), become more prevalent. Research efforts have aimed to unveil the underlying mechanism of disease pathogenesis in order to develop potential therapies. In particular, reports have focused on …
-
Studies of the Physical Stability of GLP-1 & Chemically Modified Forms of GLP-1
Biopharmaceuticals, including proteins and peptides, are becoming increasingly important as therapeutic agents. However, the clinical use of protein and peptide therapeutics is still restricted due to undesirable properties such as their ability to self-assemble and aggregate. These properties not …
-
Design and Application of Transition Metal Complexes for Catalysis
… relate to the design and discovery of short peptides that self-assemble into supramolecular structures and/or provide good catalytic results. The second chapter details the design of a short dipeptide able to self-assemble and its application in the transition-metal asymmetric transfer …
-
Dynamic supramolecular hydrogels with adaptive biological functionality
Molecular self-assembly coupled with (bio)catalysis underlie dynamic processes in biology and are considered as powerful tools for fabricating adaptive materials. In nature, the extracellular matrix (ECM) - the complex yet dynamic environment surrounding cells, provides cell support and ultimately …
-
Peptide Mediated Co-assembly of Porphyrin: Towards Sustainable Biomaterials for Light Harvesting and Catalysis
… and functions of proteins dictates by the self-assembly, where the complexity of proteins arise from a large number of amino acids. Generation of biomimetic systems that resemble the structures and functions of proteins is of great interest yet challenging due to the tremendous complexity …
-
Optimized Peptide Nanomaterials as Delivery Vehicles for Hydrophobic Metal-Based Anticancer Agents
… In this thesis we demonstrate that anionic self-assembling peptides can be utilized as delivery vehicles for metal-based hydrophobic payloads. The tunability of the system is highlighted as well as the increase in cytotoxicity and selectivity in vitro. The rapid degradation of peptides in …
-
Effect of de novo peptide properties on self-assembling large amyloid fibers
… glutamine content and hydrophobicity of template peptides on amyloid aggregation of a template-peptide system involving myoglobin was studied at near-physiological conditions by Fourier transform infrared spectroscopy, atomic force microscopy, field emission scanning electron microscopy, and …
-
Self-assembled peptide as a long-acting drug formulation
… [3]. It is known that many – if not all – peptides can be converted to self-assembled nanostructures [4]. Amyloid fibrils are characterized by enhanced chemical, biological and mechanic stability compared to soluble peptides, and allow a controlled release by dissociation of monomers from …
-
Self-assembly and aggregation of glucagon-like peptide 1 and its analogues
Aggregation and physical instability of peptide-based drugs poses a great challenge to the pharmaceutical industry. Glucagon-like peptide 1 (GLP-1) is a hormone that is used in the treatment of type-2 diabetes. However, GLP-1 has a short half-life *in vivo* and it is prone to aggregate which …