Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Peptide modification"”.
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Convergent Site-Selective Carbohydrate-Peptide Ligations With Dehydroalanine and Aziridine -2 -Carboxylic Acid-Containing Peptides
… of two convergent strategies for site-selective peptide modification and their application to the preparation of alpha-thio analogs of mucin related glycoconjugates is described. Chemoselectivity in these reactions was realized through the incorporation of dehydroalanine and …
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Development of Delivery Strategy for Adipose-Derived Stem Cells in the Treatment of Myocardial Infarction
… degrees of arginine-glycine-aspartic acid (RGD)-peptide modification was examined. More specifically, rASCs were encapsulated in MGC hydrogels with 0%, 4%, and 7% RGD modification and cultured for up to 14 days. Viability staining results indicated that rASC viability was enhanced in the 4% and …
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Modifikace peptidového substrátu pro pappalysiny zavedením pseudopeptidu do štěpeného místa
… is focused on the preparation of a modified peptide based on the structure of insulin-like growth factor binding proteins (IGFBPs), which are substrates of pappalysin metalloproteases (PAPPA-A, PAPP-A2). These enzymes regulate the bioavailability of insulin-like growth factors (IGF) by …
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Characterizing and Engineering Thioesterases as Biocatalysts for Macrocyclization
… the characterization of two non-ribosomal peptide synthetase (NRPS) TE domains and their use as biocatalysts for the chemoenzymatic synthesis of two cyclic depsipeptide NP. Unlike other characterized NRPS TEs, these two demonstrated the ability to catalyze macrolactonization with minimal …
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Electrochemically-Enabled Late-Stage Peptide C-terminal Modifications
… therapeutic relevance of C-terminally modified peptides serves as a strong impetus for the exploration of late-stage peptide C-terminal modification strategies, particularly those which enable direct functionalization of the native C-terminal carboxylate motif. Considering the discrepancy …
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Electrochemically-Enabled Late-Stage Peptide C-terminal Modifications
… therapeutic relevance of C-terminally modified peptides serves as a strong impetus for the exploration of late-stage peptide C-terminal modification strategies, particularly those which enable direct functionalization of the native C-terminal carboxylate motif. Considering the discrepancy …
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Discovery and design of novel bioactive peptides from amphibian skin secretion
… to obtain the sequences of natural antimicrobial peptides and their synthesis was achieved using solid-phase synthesis (SPPS). In addition, the peptides were purified and identified by high-performance liquid chromatography (HPLC) and MALDI-TOF MS, and their biological activity was …
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DNA enzymes for tyrosine PEGylation and azido-adenylylation of peptide and protein substrates
… more stable compared to RNA. Post-translational modifications (PTMs) are essential for protein functions. The ability to site-specifically modify peptides and proteins will enable better understanding and applications of these biomolecules. The idea of using DNA enzymes for peptide and protein …
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DNA enzymes for peptide-nucleic acid conjugation and for lysine methylation
… to RNA. An approach to site-specifically modify peptide and protein side chains will be valuable to study natural post translation modification of proteins. That approach will also be useful for artificial modification of proteins to generate homogeneous protein conjugates. The idea of using DNA …