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Showing 1 to 8 of 8 for “"Peptide mimetics"”.
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Ghrelin Processing and Maturation: Developing a Molecular-Level Framework for Hormone Activation and Biological Function
… GOAT. A majority of these studies have utilized peptide mimetics of the N-terminal sequence of ghrelin. However, the impact of downstream elements in ghrelin and its 94 amino acid precursor proghrelin remains to be fully defined. To investigate this, we have developed bacterial expression systems …
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Designing Amphiphilic Peptoids for Controlling the Formation of Nanostructured Biomimetic Materials
Biomacromolecules such as proteins and peptides achieve remarkable functionality through precise molecular sequences, enabling sophisticated folding and hierarchical assembly. However, their complexity and sensitivity in folding and assembly raise significant challenges for molecular design and …
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Part I: Disruption of PTEN-5-HT2CR Coupling: A Potential Treatment for Restoration of 5-HT2CR Function / Part II: Rapid Total Synthesis of Cyclodepsipeptide MA026
… to be preserved in the future design. Cyclic peptide 1, 2, peptidomimetic 31, and 56 with relatively good inhibitory effect of interfering with PTEN-5-HT2CR coupling were obtained. More peptide analogs, turn peptidomimetics, and looped conformation peptide mimetics were also provided for …
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Identification of A Conserved Cluster In The Rh Domain of Grk Critical For Activation By Gpcrs
… GRK5 or 6. Based on these results, we designed peptide mimetics of GRK5 helix 9 both computationally and through chemical modifications with the goal of both confirming the importance of helix 9 and developing a useful inhibitor to disrupt the GPCR-GRK interaction. Several peptides were found to …
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Characterization of D-boroala as a novel Broad-spectrum antibacterial agent targeting D-Ala-D-Ala ligase & designer linkers : model reactions and linear free energy relationships in the reactivity and design of solid-phase linkers
… by binding to the D-Ala-D-Ala termini of pentapeptide peptidoglycan precursors, thereby interfering with the last steps of bacterial cell wall biosynthesis. In the most clinically common resistance mechanisms in VRE, the terminal D-Ala-D-Ala moiety of peptidoglycan precursors is replaced by …
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Production and characterization of the recombinant wheat chitinase Wch1 and generation of chitin-specific antibodies
… of chitin-specific antibodies consisted in using peptide mimetics as substitutes of the insoluble and non-immunogenic chitin polymer. For this purpose, three peptide libraries were panned against wheat germ agglutinin (WGA) or chitin-binding domain (CBD). Five heptameric linear peptides were …
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Importance of the Gastrin N-Terminal Region in Binding and Activation of the Putative G17-Gly Receptor on Human Colonic Carcinoma Cells
… has indicated that the N-terminal portion of the peptide likely plays a role in the promotion of proliferation of cancer cells in vitro, binding to low and high affinity sites which may jointly regulate cell proliferation. Consequently, C-terminally truncated G17 analogs were synthesized and their …
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Σχεδιασμός και σύνθεση πεπτιδομιμητικών μορίων με βάση το τριμοριακό σύμπλοκο MHC-πεπτίδιο-TCR
Η Σκλήρυνση Κατά Πλάκας (ΣΚΠ) είναι μια ανοσολογικά ελεγχόμενη, φλεγμονώδης, απομυελινωτική ασθένεια, η οποία χαρακτηρίζεται από καταστροφή τη μυελίνης του Κεντρικού Νευρικού Συστήματος (ΚΝΣ) που οδηγεί σε σοβαρές παθολογικές καταστάσεις και παράλυση. Η κύρια αιτία της νόσου δεν έχει διευκρινιστεί, …