Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"Peptide hormones"”.
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Regulation Mechanisms of Peptide Hormones in Neuroendocrine Cancers
… methods for the detection and quantification of peptide hormones featuring on-line analyte concentration, post-separation tagging and HPLC-fluorescence detection were presented. These methods were used to detect and quantify calcitonin (CT) and its prohormones glycyllysyllysine-extended CT …
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Regulation Mechanisms of Peptide Hormones in Neuroendocrine Cancers
… methods for the detection and quantification of peptide hormones featuring on-line analyte concentration, post-separation tagging and HPLC-fluorescence detection were presented. These methods were used to detect and quantify calcitonin (CT) and its prohormones glycyllysyllysine-extended CT …
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Steady State and Theoretical Investigations of Peptidylglycine α-Amidating Monooxygenase (PAM)
Approximately 50 percent of all known peptide hormones are post-translationally modified at their C-terminus. These peptide hormones are responsible for cellular functions critical to survival. Peptidylglycine alpha-amidating monooxygenase (PAM) is a bi-functional enzyme which catalyzes the …
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Mechanistic Studies of Peptidylglycine Alpha-Amidating Monooxygenase (PAM)
Peptide hormones are responsible for cellular functions critical to the survival of an organism. Approximately 50% of all known peptide hormones are post-translationally modified at their C-terminus. Peptidylglycine alpha-amidating monooxygenase (PAM) is a bi-functional enzyme which catalyzes the …
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Nutrient Transport During Hypoperfusion
… alteration. It is possible that nutrients and peptide hormones can be used to upregulate nutrient transport in the compromised state. The addition of butyrate in vitro and ex vivo caused an increase in SGLT-1 transporter activity. Therefore, a study was performed to test the luminal addition of …
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An investigation of the role of Arabidopsis thaliana plant natriuretic peptide in planta
… to be communicated by five classical plant hormones - auxin, cytokine, gibberellic acid, absisic acid and ethylene. Nowadays a plethora of other molecules are known to fulfil this function including nitric oxide, salicylic acid, jasmonic acid, brassinosteroids and peptide hormones. Plant …
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Vasopressin decreases excitability in rat lateral amygdala neurons through inhibition of hyperpolarization-activated cationic current.
… social functioning is a primary symptom. The peptide hormones arginine-vasopressin (AVP) and oxytocin (OT) are strongly implicated in social behavior, and may also be involved in the pathophysiology of ASD. Here, we show that AVP causes an increase in excitability, through eliciting a decrease …
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Effects of hormones, genetics, and sex on typical and atypical brain organization
… part of the thesis examines the acute effects of hormones on brain connectomics. Hormones are an integral part of the mechanism of social behaviour. In a series of hormone administration studies, we report experiments to test the acute effects of steroid and peptide hormones on brain functional …
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Thioamides And Proteolysis: Examining The Effects And Applications Of A Single-Atom Substitution
Thioamide substitution in the peptide backbone enables several applications in studying proteolysis, monitoring protease activity and in selective protease inhibition. To date, we have used model substrates to investigate the positional effects that these thioamide substitutions have on proteolysis …
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Neuropeptidomics Across Metazoan Life
… a sea of diverse signaling molecules, including peptides. It is well known that neuropeptides, acting as neurotransmitters, neuromodulators and peptide hormones, play pivotal roles in a variety of physiological processes, such as learning and memory, sleeping, pain, and anxiety. To understand how …
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A peptidomic investigation into enteroendocrine cells and islets of humans and mice
… content of the blood and responding by secreting peptide hormones to control various physiological functions. This thesis focuses on characterising the peptidome of EECs and islets by utilising liquid-chromatography coupled to mass spectrometry (LC-MS). Due to their ability to control food intake …
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Cardiovascular Effects of GLP-1 and Glucagon Dual Receptor Agonism in Humans
… peptidase IV inhibitors, glucagon like peptide-1 (GLP-1) receptor agonists and selective sodium-glucose transporter-2 inhibitors (SGLT2i). These medications have transformed treatment pathways and prognosis for individuals with T2DM as well as obesity (GLP-1 receptor agonists), heart …
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The immediate and long-term consequences of temporary exposure during adulthood to di(2-ethylhexyl) phthalate and diisononyl phthalate on female reproduction
… structure that produces a variety of sex steroid hormones and participates in several feedback loops within the hypothalamic-pituitary-ovary axis. Further, it is the site of storage and maturation of the female gamete: the oocyte. Females are born with a finite number of oocytes in the form of the …
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Mapping signaling networks and rapidly evolving genes in the developing Arabidopsis seed at single-nucleus resolution
… characterizing the extent of short, secreted peptide expression in specific seed cell types, I perform in silico screens to match potential peptide hormones with their receptors. In total, I show that the seed coat shows functional compartmentalization around the gateway for maternal resources …
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Endogenous glucagon-cells are necessary for the glucose-responsiveness of the HIT-T15 hamster β-cell line
… and glucose-dependent insulinotropic polypeptide (GIP) had no effect. When HIT-T15 cells were incubated in conditions of zero-glucose and glucose plus glucagon-Ab there was no significant difference in insulin release (p >0.05). Furthermore, glucagon-Ab inhibited glucose-stimulated insulin …
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An exploration of lipids with the potential to influence appetite and food intake
… status. This effect is not mediated by gut peptide hormones measured in this thesis but appears to be related to a delay of gastric emptying, and potentially an increase in ketone body production. These effects are only observed in resting conditions, whereas consuming them alongside …
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Sorting of Cargo Proteins Within the Regulated Secretory Pathway: the Peripheral Membrane Protein HID-1 as a Sorting and Vesicle Biogenesis Factor
… (TGN) and mediate the regulated release of neuropeptides and peptide hormones. Despite their central role to physiology, the mechanisms controlling biogenesis and sorting to LDCVs is not well understood. Optimizing the retention using selective hooks (RUSH) method in neuroendocrine cells, we show …
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Ryanodine receptor expression in trophoblasts
… Furthermore, endogenous placental peptide hormones, namely angiotensin II, arginine vasopressin and endothelin 1, were demonstrated to increase [Ca2+]i in BeWo cells, and such increases were suppressed by RyR antagonists and by blockers of the corresponding peptide hormone …
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Evaluation of a plasmid delivery system for production of GnRH and GHRH in the horse and goat
… conclusion, electroporatic plasmid delivery of peptide hormones may serve as an effective technique for expression of protein hormones in the horse and goat.
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Using sequence data to investigate the functional design of proteins
… For example, the set of paralogous polypeptides present in the genome of modern vertebrates give rise to the variety of collagen proteins. These proteins preserve a high degree of sequential and structural homology, yet are optimised by evolutionary processes to perform their specific …
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