Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Peptide functionalisation"”.
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Peptide functionalisation and characterisation of gold (nano) surfaces
… successful preparation and characterisation of peptide functionalised gold surfaces, with a focus towards developing enzyme response applications. The serine protease, elastase, was the primary focus of this work; however, all of the systems described herein have the utility to be modified for …
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Chemical Methods for Cobalt-Catalysed C(sp3)–H Activation and Iodonium Salt-Mediated Peptide Functionalisation
… range of substituted analogues, including to the functionalisation of activated methylene bonds. Initial computational interrogation of the reaction suggests a carboxylate-assisted concerted metalation-deprotonation pathway for C–H bond cleavage. Subsequently, the development of a rapid, …
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The development of functionalised stapled peptides as chemical tools to modulate biological processes in platelets and as novel antimicrobial therapeutics targeting Pseudomonas aeruginosa
Peptides are useful modulators of protein-protein interactions (PPIs) and cellular membranes, both of which are traditionally challenging to target using small molecules. Often therapeutic peptides suffer from issues including poor proteolytic stability. Two-component peptide stapling can improve …
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Architectural, mechanical and biochemical control of collagen films and scaffolds to guide neural- and fibroblast cell behaviour
Collagen-based scaffolds offer the potential to bridge gaps in damaged nerves via infiltration of cells along oriented pore structures which can guide sprouting axons and direct Schwann cell migration. Neural cells have been shown to be highly mechanosensitive and hence substrate stiffness is an …