Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 14 of 14 for “"Peptide epitopes"”.
-
Engineering more potent vaccines for the treatment of cancer and autoimmunity
… studies sought to improve the delivery of peptide epitopes to lymphoid organs by fusing epitopes to inert protein carriers with defined pharmacokinetic properties. To promote anti-tumor immunity, we found that antigen carriers should 1) protect peptide cargo from proteolytic degradation, 2) …
-
Polysequence Nanomaterials for Immunomodulation
<p>Peptide-based vaccines have received growing interest due to their specificity and ability to limit off-target effects, and they are currently being explored toward a variety of infectious diseases and therapeutic targets. However, the efficacy and applicability of such epitope-based vaccines …
-
CD8+ T Cells Are Required for the Therapeutic Action of Glatiramer Acetate in Autoimmune Demyelinating Disease
… vivo. Additionally, several MHC class I-binding peptide epitopes associated with GA treatment of dendritic cells were identified by LC/MS-MS and tested for disease suppression and ability to activate GA CD8+ T cells. These studies demonstrate an essential role for CD8+ T cells in GA therapy and …
-
Analysis and optimization of immune responses elicited by Outer Membrane Vesicles (OMVs)
… the immunogenicity of OMVs decorated with T cell epitopes in inducing epitope-specific IFNγ+ CD4+ and CD8+ T cell responses. In particular, we analysed important aspects such as the amounts of OMVs and heterologous antigen necessary and sufficient to reach the plateau of antigen-specific T cell …
-
Targeting the Neonatal Fc Receptor, FcRn, to Treat Autoimmunity and Elucidation of Sites of FcRn Function
… to develop a novel platform for the delivery of peptide epitopes as Fc-peptide fusions with different dynamic properties. Using very low doses of these engineered antigens to avoid anaphylactic shock, the study demonstrates that the longevity of the peptide antigen is the primary determinant of …
-
Lipid-coated micro- and nanoparticles as a biomimetic vaccine delivery platform
… by the goal of properly displaying minimal peptide epitopes from the Membrane-Proximal External Region of HIV gp41 (MPER) and enhancing their immunogenicity. Display within a lipid context was needed to provide the chemical environment appropriate for neutralizing antibodies, such as 4E10, …
-
Bead-basierte Fluoreszenz-Immunoassays zum Nachweis tumorinduzierter Proteine
… against p53 by a sandwich method using peptide epitopes of the tumorsuppressor was successfully performed for three epitopes of which one was known to be immunodominant. For this peptide 12 out of 19 sera from lung cancer patients (63 percent) showed a significant reaction towards the …
-
Advancing T Cell–Based Immunotherapies: Identification of Tumor-Specific T Cell Receptor Targets and Mechanisms of Resistance in Solid Tumors
… to identify novel immunogenic, tumor-associated peptide epitopes and validate their immunogenicity. Through this strategy, we identified an HLA-A*24:02–restricted epitope derived from PDZ-binding kinase (PBK), a serine/threonine kinase involved in cell proliferation and recognized as an …
-
Development of polymeric nanoparticle vaccines for immunostimulation
… a tunable surface for loading B cell antigen epitopes in a specific conformation to drive epitope-specific antibody response. In recent decades, TLR mechanisms have been elucidated and novel agonists have been developed, yet our generation still has not seen paramount progress in the clinical …
-
Characterisation of novel peptides as candidates for diagnosis of schistosomiasis
… the reactivity of Schistosoma linear B-cell peptide epitopes via serological assays to assess their potential as diagnostic biomarkers. METHODOLOGY: In-silico analyses were carried out to identify protein family, sequence conservation and potential cross-reactivity of five selected peptides …
-
Supramolecular Peptide Nanofiber Vaccines for Eliciting CD8+ T-cell Responses
… cancers. Subunit vaccines using whole protein or peptide epitopes are becoming increasingly favored due to their superior safety profile compared with live-attenuated or inactive pathogen formulations. The immunogenicity of subunit vaccines often depend heavily on adjuvants. Currently approved …
-
Identification of candidate tumour antigen peptides with immunogenic potential for use in cancer immunotherapy
… CD4+ T cells recognise antigen in the context of peptide presented on MHC class II molecules, therefore recent research has focused on the identification of these peptides in order to formulate more effective immunotherapeutic strategies. As such, the aim of this study was to identify novel MHC …
-
Novel approaches towards vaccine developments against porcine circovirus type 2 and porcine reproductive and respiratory syndrome virus
… vaccine virus (vs) to express four known B-cell epitopes of PRRSV. Peptide epitopes of PRRSV-VR2385, including GP2II (aa 40–51, ASPSHVGWWSFA), GP3I (aa 61–72, QAAAEAYEPGRS), GP5I (aa 35–46, SSSNLQLIYNLT), and GP5IV (aa 187–200, TPVTRVSAEQWGRP) were inserted in frame into the C-terminus of the …
-
Identifikation und immunologische Charakterisierung von MHC-Klasse-II-Peptidepitopen in humanen Leukämie- und Lymphom-assoziierten Antigenen
… Hauptziel dieser Arbeit war es, MHC Klasse-II Peptidepitope in den Proteinen zu identifizieren, welche eine tumor-assoziierte Expression aufweisen und die bereits bekannte Zielantigene von zytotoxischen T-Zellreaktionen sind. In dieser Arbeit wurden die Proteine Proteinase 3 (PR3) und Survivin …