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Showing 1 to 4 of 4 for “"Peptide docking"”.
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Regulation and Dysregulation via Docking Interactions in WNK and ERK1/2 MAPK Signaling
… interactions, and in particular protein-peptide docking interactions, within two independent cellular signaling pathways, the WNK, and ERK1/2 MAPK pathways. The WNK pathway is an essential regulator of cellular ionic composition and volume. Initially discovered due to the genetic link …
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Nuclear Export Receptor CRM1 Recognizes Nuclear Export Signals with Diverse Conformations
… strategy to crystallize CRM1 bound to NES peptides in order to study how diverse sequences bind CRM1. In the first study, I solved crystal structures of CRM1 bound to NESs with unusual sequences, which bound the CRM1 groove in the opposite orientation (minus) to that of previously studied …
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Entwicklung und Charakterisierung von Komplexen aus Cetrorelix und biophilen Trägermaterialien
Die Dissertation beschreibt Arbeiten zur Herstellung neuer Cetrorelixkomplexe, zur Kinetik der dynamischen Liberation, zur Struktur von Aggregaten und Komplexen von Cetrorelix und zur Berechnung von Komplexeigenschaften mit Molecular Modeling.
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Computational modeling of protein-protein and protein-peptide interactions
Protein-protein and protein-peptide interactions play a central role in various aspects of the structural and functional organization of the cell. While the most complete structural characterization is provided by X-ray crystallography, many biological interactions occur in complexes that will not …