Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 13 of 13 for “"Peptide design"”.
-
Modulating Cariogenic Interfaces Through Machine Learning-Guided Peptide Design
… and dentin. Previously, our group investigated a peptide-enabled approach for biomimetic reconstruction of SDF-treated dental tissues to mitigate the undesired effects. A silver binding peptide was explored to provide an anchoring ability on SDF-treated tissues with an additional remineralization …
-
MOLECULAR DYNAMICS SIMULATIONS OF BIOLOGICAL MACROMOLECULES: APPLICATIONS TO STRUCTURAL VACCINOLOGY AND PEPTIDE DESIGN
… folding/unfolding processes of small natural polypeptides. Starting with the first topic, an increasing number of functional studies of proteins have shown that sequence and structural similarities alone may not be sufficient for reliable prediction of their interaction properties. This is …
-
Effiziente Konformationsanalyse von Peptiden
… of the structures of glycomimetic cyclic hexapeptides contributes to understanding the basis of the mimicry of the L2/HNK1 epitope, a carbohydrate structure with several important functions, in particular in the peripheral nervous system. The structures of cyclic penta- and hexapapetides show …
-
Developing Low Fouling Peptides and Zwitterionic Materials for Biomedical Applications
… prevent biofouling in biomedical applications. Peptides are considered for use as natural low fouling materials due to their biocompatibility, diverse chemical properties, well-defined sequence, and biodegradability. Low fouling peptide sequences were rationally designed from known zwitterionic …
-
The Rational Design of Coiled-Coil Peptides towards Understanding Protein-Crystal Interactions and Amorphous-to-Crystalline Transitions
… combine biomineralization research and rational peptide design using the coiled-coil peptide motif and calcium hydrogen phosphate dihydrate (CaHPO4 x 2H2O), commonly known as brushite. Coiled-coils were designed to alter the complete growth pathway of brushite beginning with an amorphous …
-
Explainable Machine Learning Prediction of Antimicrobial Peptide Targeting Streptococcus mutans
… an explainable machine learning pipeline to design antimicrobial peptides targeting S. mutans in responsiveness to the acidic conditions of the cariogenic microenvironments. Our explainable ML pipeline approach transforms the targeted peptide design into a data-driven methodology and bridges …
-
Fundamental study of natural and synthetic antimicrobial peptides as novel preservatives against fungal food spoilage
… aims to consider the potential of antimicrobial peptides as novel preservatives against spoilage fungi of food products. Antimicrobial peptides are short (<100 amino acids) components of the innate immune system widely spread amongst eukaryotic and prokaryotic kingdoms. A literature review about …
-
A Dual-Domain Peptide Strategy for Targeted Regenerative Repair
… aims to develop and evaluate a modular synthetic peptide designed to enhance tissue regeneration through coordinated extracellular matrix targeting and immune modulation. The peptide construct incorporates a collagen-binding domain (CBD) to spatially localize bioactivity within matrix-rich …
-
Studies of protein folding on membranes and in crowded environments and bridging the research-teaching gap in K-12 science
This work deals with three important problems in membrane protein folding studies, namely the preparation and storage of homogeneous small unilamellar vesicles (SUV), the development of an algorithm for selecting soluble trans-membrane helices from known membrane proteins, and the characterization …
-
Regulating the Biomedical and Biocatalytic Properties of Amphiphilic Self-assembling Peptides via Supramolecular Nanostructures
… or induced by environmental factors. Peptides, short chains of amino acids, can self-assemble into many types of nanostructures. The self-assembly of peptides is governed by noncovalent interactions, including electrostatic interactions, hydrogen bonding, hydrophobic interactions, …
-
Identification, molecular cloning and modification of skin-derived bioactive peptides from selected Hylidae and Ranidae
… One of the greatest adaptations was the peptides secreted from the skin, which are of great importance to maintain their everyday life. Diverse bioactivities and potential pharmaceutical functions of peptides have been confirmed by researchers in recent years. Many peptides show …
-
Design of Collagen-Mimetic Peptides
… self-assembled fibrils through protein design have not been successful.</p> <p>In this work, we describe the self-assembly of a collagen-like <em>periodic mini-fibril</em> from a recombinant collagen triple helix. The triple helix, designated Col108, is expressed in <em>E. coli</em> …