Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Peptide complex"”.
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Structure determination of an HIV-1 RRE RNA-Rev peptide complex by NMR spectroscopy
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1996.
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An examination of peptide-tether binding to gold and glass surfaces
… applications, it is beneficial to know that a peptide will bind to a surface. In this thesis, a tether, bead, peptide complex is constructed using the gold binding peptide (GBP) of sequence (CGGVSGSSPDS). Several assays and assay modifications are developed and tested to attempt to attach the …
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The role of idiotype-specific immunity in antigen receptor diversity
… frequency of CDR3-derived HLA-A2 binding peptides in HLA-A2+ donors (0.03% (SYFPEITHI) and 0.35% (BIMAS)) compared with HLA-A2- donors (0.24% (SYFPEITHI, p=0.01) and 0.54% (BIMAS, p=0.19)). Trends similar to those seen in HLA-A2 were observed in other HLA alleles as well suggesting that …
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Biophysical Investigations of the Cytosolic Iron-Sulfur Cluster Assembly Pathway Late Acting Proteins
… CIA pathway in eukaryotes. They form a protein complex (the CIA targeting complex, or CTC) that appears to be responsible for the delivery and installation of iron-sulfur clusters into apo-target proteins, such as the [4Fe-4S] cluster protein Leu1. However, how the CTC recognizes Nar1 and Leu1 …
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Characterizing antigen-specific CD4⁺ T cells using HLA-DR oligomers
… surface T cell receptors (TCR) by antigenic peptide bound to major histocompatibility complex (MHC). The success or failure of this TCR to MHC-peptide interaction determines the specificity of T cell action, and thus plays a central role in proper immune function. In this thesis, soluble …
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Protein/Peptide Recognition Modules in Cellular Signaling and HIV Pathogenesis
<p>The peptide-recognition domains play a key role in Eukaryotic signal transduction by mediating sequence-specific interactions with their protein/peptide ligands. In this thesis, I illustrate in molecular detail the recognition mechanisms utilized by three peptide-recognition domains: SH2 (Src …
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Platinum-NGR A Peptide Targeting Conjugate Of Cisplatin: Design, Synthesis, And Efficacy In Breast Cancer Cells
… we synthesized a platinum-Asn-Gly-Arg (NGR) peptide conjugate with a long-term goal of reducing adverse effects in patients, as well as combating possible drug resistance compared with other widely available platinum-based chemotherapeutics. NGR peptide motifs are specific to angiogenic …
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Zink-Peptid-Komplexe als Modellsubstanzen natuerlicher Metalloproteine
… von Aminosäurederivaten sowie Peptiden gegenüber Zinkionen im Hinblick auf die Koordination von Zink in natürlichen Metalloproteinen mit Hilfe der Methode der potentiometrischen Titration zu untersuchen, sowie Komplexe von Aminosäurederivaten und Peptiden herzustellen, zu …
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Entwicklung und Charakterisierung von Komplexen aus Cetrorelix und biophilen Trägermaterialien
Die Dissertation beschreibt Arbeiten zur Herstellung neuer Cetrorelixkomplexe, zur Kinetik der dynamischen Liberation, zur Struktur von Aggregaten und Komplexen von Cetrorelix und zur Berechnung von Komplexeigenschaften mit Molecular Modeling.