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Showing 1 to 14 of 14 for “"Peptide chemistry"”.
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Heterocycles in peptide chemistry
… to restrict the conformational freedom of the peptide.<br></br><br></br> Cycloaddition of a nitrile oxide, derived from a Boc-protected naturally-occurring a-amino acid, with a pyrrolidine en amine led to a Boc-protected 3-aminoalkylisoxazole amino acid ester. The nitrogen and carbon termini of …
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Newer methods in peptide chemistry.
Massachusetts Institute of Technology. Dept. of Chemistry. Thesis. 1970. Ph.D.
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Development And Applications Of Thioacids In Peptide Chemistry And Exploration Of Methods Toward The Stereochemical Elucidation And Synthesis Of Virgineone
… <p>DEVELOPMENT AND APPLICATIONS OF THIOACIDS IN PEPTIDE CHEMISTRY AND EXPLORATION OF METHODS TOWARD THE STEREOCHEMICAL ELUCIDATION AND SYNTHESIS OF VIRGINEONE</p> <p>by</p> <p>KASINATH SANA</p> <p>December 2010</p> <p>Advisor: David Crich</p> <p>Major: Chemistry</p> <p>Degree: Doctor of …
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A bioactive peptide, QUB-2048, from the defensive skin secretion of Phyllomedusa tomopterna
… of bioactive compounds and antimicrobial peptides (AMPs) are among the most attractive of these. Due to antibiotic resistance and the eager need of developing new types of anti-infective drugs, such peptides are considered as an alternative therapeutic option due to their potent …
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Design, Synthesis, and Evaluation of Oleyl-WRH Peptides for siRNA Delivery
… one of the major challenges. Cell-penetrating peptides (CPPs) containing arginine (R), tryptophan (W), and histidine (H) have been promising for siRNA delivery. Therefore, to enhance siRNA delivery and efficient silencing of the STAT3 gene, herein, we hypothesized to use of fatty acylation with …
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Molecular structure, hierarchical assembly and stimuli-responsive mechanics of tropoelastin and elastin biomaterials
… temperature response spectrum of elastin-like peptides to design synthetic polymers with tunable switching. We resolve the effect of peptide chemistry, chain length, and solvent environment on structural transitions, based on local molecular structure, peptide dynamics and interaction with …
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The design and synthesis of fluorescent peptides and disaccharides for tumour imaging.
Chapter 1: Peptide targeting of integrin αvβ3 Integrins are cellular surface receptor proteins involved in numerous cellular signalling and adhesion processes. The integrin αvβ3 subtype is up-regulated around sites of malignancy especially solid tumour masses. This is due to its expression on the …
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Designing Direct and Indirect Factor Xa Inhibitors
… large number of compounds using well established peptide chemistry. Mechanistically, the designed inhibitors were expected to bind to FXa in the active site and function as orthosteric inhibitors. These direct FXa active site inhibitors are also likely to inhibit clot–bound enzyme. Nearly 60 THIQ …
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Elucidating the role of peptidoglycan from Borrelia burgdorferi in Lyme disease pathogenesis
… shown atypical differences in both glycan and peptide chemistry that likely alter immune recognition. Due to a lack of necessary enzymes and transporters B. burgdorferi are unable to recycle their peptidoglycan as they elongate and produce daughter cells. This leads to a 45% reduction of their …
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Smart Nanomaterials from Repeat Proteins and Amyloid Fibrils
… the design and synthesis (using solid-phase peptide chemistry) of a peptide based on the previously known TTR105-115 peptide (derived from the amyloidogenic Transthyretin protein). These fibrils were characterised by AFM and TEM and it was then shown that the assembled fibrils could be …
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Structure–Activity Analysis of Peptide-Mediated Quorum Sensing in Streptococcus mitis
… is controlled by the competence-stimulating peptide (CSP), which activates the histidine kinase receptor ComD to drive QS-regulated processes. To define the molecular interactions that drive CSP1:ComD binding and lead to ComD activation, we conducted a systematic structure-activity analysis …
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The development of stapled peptides as chemical tools to investigate activin A signalling and as antibacterial agents targeting MsbA-mediated efflux
Peptides are recognised for their ability to disrupt protein-protein interactions (PPIs), which have traditionally been considered ‘undruggable’ with small molecules. However, due to issues such as a susceptibility to degradation by proteases, the use of peptide therapeutics in the clinic has been …
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CYCLIZATION-BASED SITE-SELECTIVE N-TERMINAL CYSTEINE CONJUGATION, PEPTIDE STAPLING AND HISTONE DEACETYLASE (HDAC) PROBING
… modify N-terminal cysteines of unprotected peptides or proteins in a single step. We showed that α-fluoroketone molecules afford the cyclization reaction with the beta amino thiol group of N-terminal cysteine. Both chemo and stereo-selectivity of this reaction have been studied using 2D NMR …
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Characterizing Non-Covalent Interactions And Peptide Bond Formation With Electronic Structure Theory
… 2 provides a mathematical overview to quantum chemistry including a brief presentation of the analytic solutions to the schrã¶dinger equation for some model systems. Chapter 3 and chapter 4 introduces some commonly used methods and basis sets, respectively, used in electronic structure theory. …