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Showing 1 to 14 of 14 for “"Peptide antibiotics"”.
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Design and synthesis of modified peptide antibiotics of the vancomycin family
… vancomycin complexed to a mimic of the cell wall peptide. This structure was used in conjunction with the de notvo design program SPROUT as the basis for molecular design, in order to create analogues of vancomycin that were predicted to offer increased affinity for the tripeptide cell wall mimic. …
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Studies on the Mechanism of Action of the Peptide Antibiotics, Polymyxin B and Em 49. (Octapeptin)
Made available in DSpace on 2014-12-14T04:27:39Z (GMT). No. of bitstreams: 1 7726742.pdf: 7374914 bytes, checksum: 5b402efe22870e63b3b6a41d816838af (MD5) Previous issue date: 1977
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From Peptide Precursors to Lanthionine -Containing Peptide Antibiotics Using the First Isolated and Active Lacticin 481 Synthetase: Mechanistic Studies and Peptide Engineering
… treatment with the protease Lys-C, the modified peptide in the absence of the leader sequence and the first Lys residue showed biological activity. Mechanistic studies with the active LctM disclosed that the activity of LctM absolutely requires both Mg2+ and ATP. The products of ATP were …
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Investigating Antibiotic Biosynthesis Using Quadrupole-Fourier Transform Mass Spectrometry
… mechanistic insight into the biosynthesis of peptide antibiotics produced either nonribosomally or by extensive post-translational modification of a ribosomally-encoded precursor.
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The discovery and bioactivity evaluation of a novel peptide, QUB-2652, from the skin secretion of the South American frog, Phyllomedusa palliata
… bacteria has stimulated the development of new antibiotics. Antimicrobial peptides (AMPs) from amphibian skin secretions possess broad-spectrum antimicrobial activities through the mechanism that is unlikely to induce antibiotic resistance. Thus, AMPs are great candidates for new antibiotics. …
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QUB-3005, a bioactive peptide from the defensive skin secretion of Rana amurensis
… amines, steroids, complex alkaloids, and peptides. In the latter class of molecules, a large number of peptide antibiotics has been isolated and characterised from different amphibian species. Particularly, antimicrobial peptides (AMPs) are considered as excellent candidates for …
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The preparation of racemic and optically active beta-amino-acids and their utilisation in peptide formation.
… are being isolated from biologically active peptide antibiotics with increasing frequency nowadays. Recognition of the importance of these amino acids, has led to their incorporation into synthetic peptide analogues and into polymers. The main part of this thesis reports the successful …
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Mechanistic Investigations of Cyclase Enzymes Involved in Lantibiotic Biosynthesis
Lantibiotics are peptide antibiotics that contain thioether bridges, termed lanthionines, putatively generated by Michael addition of cysteines to dehydrated serine and threonine residues in the pre-lantibiotic peptide. In class AI lantibiotics, the post-translational modifications are proposed to …
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Synthesis of an isotopically labelled analog of the antimicrobial peptide ll-37
… cathelin-associated broad spectrum antibiotic peptide of human neutrophils. Its mechanism of action is by disruption of the bacterial cell membrane structure. LL-21 is a simplified form of the peptide that contains only the core portion of LL-37, which retains antimicrobial activity and is …
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Synthesis and solid state F-NMR studies on fluorine-labeled antimicrobial peptide RK-21
<p>Antimicrobial peptides act against bacteria by binding non-specifically and disrupting their outer membrane. LL-37 is the only member of the cathelicidin group of antimicrobial peptides present in humans and shows a broad range of antimicrobial activity. RK-21 is a fragment of human …
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Single molecule studies of ligand-DNA interactions using atomic force microscopy
… unobserved, intermolecular binding mode of the peptide antibiotics echinomycin and TANDEM. In certain circumstances, these ligands are revealed to bind exclusively to the termini of separate DNA strands in a sequence dependent fashion. This finding may have implications for the employment of …
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Actions of Antimicrobial Peptides and Bacterial Components in Inflammation
Antimicrobial peptides are evolutionally ancient parts of the innate immune system and their primary role is to protect us from infections. The human cathelicidin-derived antimicrobial peptide, LL-37, not only possesses broad spectrum antimicrobial activities but is also able to bind and neutralize …
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Screening environmental actinobacteria for antimycobacterial antibiotics and characterisation of Kribbella stellenboschensis sp. nov
… for seven isolates to produce ansamycin, glycopeptide, non-ribosomal peptide, and/or TypeII polyketide antibiotics was determined by detection of antibiotic biosynthetic gene clusters using PCR. Strain M27 demonstrated the potential to produce all the aforementioned antibiotics. Strain Y10 …