Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Peptide Release"”.
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Mechanisms of dendritic peptide release
… the mechanism that regulates this differential release is that dendrites utilise different vesicle pools compared to those found in terminals. Little is known for the function of neuronal dendrites, especially the mechanism for peptide release. One theory is that vesicles stored in dendrites are …
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Analyzing peptide release using mass spectrometry
Neuropeptides are cell-to-cell signaling molecules that act as neurotransmitters, neuromodulators and hormones that impact a large variety of neuronal processes. The term neuropeptide refers to bioactive peptides made in neuron, stored in vesicles, and released into the extracellular space. While …
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Using microfluidics and mass spectrometry to study peptide release from neurons
… function to a damaged neural network. Neuropeptides are a class of signaling molecules that are involved in a wide range of physiological functions including sleep, learning and memory, feeding, and pain. Abnormal levels of neuropeptides have been implicated in a number of diseases and …
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Characterization of peptide release from neuronal cells with microfluidics and mass spectrometry
… these signaling molecules, including neuropeptides, is an important but challenging task. Microfluidic technology allows the manipulation of mass-limited samples and the control of the extracellular microenvironment, making it well suited for studying neurons. In this work, we developed …
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A Dual-Domain Peptide Strategy for Targeted Regenerative Repair
… aims to develop and evaluate a modular synthetic peptide designed to enhance tissue regeneration through coordinated extracellular matrix targeting and immune modulation. The peptide construct incorporates a collagen-binding domain (CBD) to spatially localize bioactivity within matrix-rich …
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Aib(2)oxyntomodulin Peptide Molecular Self-Assembly: Smart Nanostructures Toward Long Acting Formulation for Obesity and Diabetes Type 2
… (s.c.) space, the plasma half-life of Oxm peptide, upon release from the fibril, was short in serum due to the proteolytic degradation by DPP4, which limits the Oxm biological role. Furthermore, previous study reported that an analogue of Oxm, aminoisobutyric acid (2) oxyntomodulin known as …
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Manipulation and characterization of proopiomelanocortin (POMC) neurons in the hypothalamic regulation of energy balance
… the maintenance of energy balance. POMC neurons release peptide transmitters that modulate pathways involved in food intake, energy expenditure, and reward pathways. POMC peptide release can result in the inhibition of food intake and increased activation of these cells is thought to precipitate …