Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 78 for “"Peptide Binding"”.
-
Exploration of Small Peptide Binding Interactions with Inorganic Surfaces Across Timescales
Peptide adhesion presents a novel method of binding surfaces which could not otherwise be permanently bound through conventional methods. Two such surfaces of practical interest are titanium dioxide (the surface of osseous implants) and hydroxyapatite (the primary mineral component of bone). The …
-
Support Vector Machine-based Fuzzy Systems for Quantitative Prediction of Peptide Binding Affinity
Reliable prediction of binding affinity of peptides is one of the most challenging but important complex modelling problems in the post-genome era due to the diversity and functionality of the peptides discovered. Generally, peptide binding prediction models are commonly used to find out whether a …
-
Modeling Peptide-binding Interactions and Polymer-binding Interactions and their Role in Mass Spectrometry
… weight compounds that bind to amyloid beta peptides (Abeta) peptides using electrospray ionization mass spectrometry (ESI-MS). Low molecular weight (LMW) compounds capable of interacting with soluble Abeta may be able to modulate/inhibit the Abeta aggregation process and serve as potential …
-
Probing peptide binding to the second PDZ domain of hPTP1E using FT-IR and MS
Three peptides were evaluated for binding to the second PDZ domain of human protein tyrosine phosphatase 1E using FT-IR and mass spectrometry. This PDZ is known to bind the C-terminal motif X-Ser/Thr-Val. MS demonstrated the formation of a 1:1 complex between PDZ and ENEQVSAV but not with peptides …
-
Requirement of ßDELSEED-Motif of <em>Escherichia coli</em> F<sub>1</sub>F<sub>O</sub> ATP Synthase in Antimicrobial Peptide Binding.
… and hydrolyzing ATP. Lately, α-helical cationic peptides such as melittin and melittin related peptide (MRP) were shown to inhibit <em>E. coli</em> ATP synthase. The proposed but unconfirmed site of inhibition is βDELSEED-motif formed by the residues 380-386, located at the interface of α/β …
-
Etablierung konditionaler Knock-out Mäuse für ERAB (endoplasmic reticulum-associated amyloid ß-peptide binding protein) : funktionelle Analysen zur Bedeutung für die T-Zellentwicklung und den Stoffwechsel
… („endoplasmic reticulum-associated amyloid β-peptide binding protein“) deuteten darauf hin, dass dieses Protein in Entzündungsreaktionen und in der T-Zell-Apoptose involviert sein könnte. In der vorliegenden Arbeit wurden daher konditionale Knock-out Mäuse für ERAB hergestellt. Der komplette …
-
Evaluating the predictive performance of cytotoxic T lymphocyte epitope prediction tools using Elispot assay data
… predict potential human leukocyte antigen (HLA) binding peptides from protein sequences. These tools are complements of Enzyme-linked immunosorbent spot (ELISpot) assays - a very commonly applied immunological technique that is used both to identify regions of pathogen genomes that trigger an …
-
Elucidation and control of substrate recognition during RiPP biosynthesis
… synthesized and posttranslationally modified peptides (RiPPs) are a rapidly growing class of natural products. RiPP precursor peptides can undergo extensive enzymatic tailoring to yield structurally and functionally diverse products. Cyclodehydratases are a type of RiPP modifying enzyme that …
-
Investigating bacterial adhesion proteins as tools for controlling bacteria-surface interactions
… are cell-surface proteins that initiate target binding and surface colonization by bacteria on the path to infection and biofilm formation. A deeper understanding of the interactions between adhesins and their ligands may lead to the development of strategies for controlling infection and …
-
Determinants of protein-peptide interaction specificity in the Bcl-2 and TRAF families
Protein-peptide interactions have important roles in the majority of cellular processes. There are many families of peptide recognition domains in which homologous members display differential binding preferences for peptide sequence features. Peptide binding specificity is critical for the …
-
Investigating antimicrobial resistance mechanisms in Neisseria gonorrhoeae using peptide probes
… binds commercial antibiotics and antimicrobial peptides. -lactam antibiotics not only bind MtrR but are hydrolysed by the multidrug protein. Evidence for this novel enzymatic activity is provided by ITC, mass spectrometric and microbiological techniques. A series of peptides derived from LL-37 …
-
Novel peptide antigens provide insights into the recognition process by T cells
… the reactivity of T cell receptors with novel peptide antigens. The first study (Chapter 2) described a collection of novel peptide antigens for a single T cell receptor and their diverse requirements for the co-receptor CD8. One of the peptides showed no activity despite binding the TCR, and …
-
The Major Histocompatibility Complex in Rabbits
… bind intracellularly or extracellularly derived peptides and display these epitopes for T-cell recognition, thereby facilitating the elimination of pathogens or the establishment of self-tolerance. The MHC is traditionally classified into three classes termed MHC-I, MHC-II, and MHC-III. MHC-I …
-
Conserved Non-Pocket Interactions Drive The Diversity of Peptide Presentation By Mhc Class I Molecules
… or transformed cells through recognition of peptides presented on human leukocyte antigen (HLA) molecules. A thorough understanding of peptide-HLA interactions is needed for improvement of CTL-based immunotherapies. We observed that aspartic acid (D) and glutamic acid (E) at peptide position …
-
Allosteric activation of periplasmic HtrA proteases
… activation occurs as a consequence of the linked binding of unassembled outer-membrane proteins to the PDZ domains and RseA to the DegS active sites. In Chapter 2, I probe the pathway of communication between the PDZ and protease domains and identify a set of residues crucial for signal …
-
Protein potentials and domains : re-use and composability
… on a specific set of protein domains, known as peptide-binding domains (PBD), that play a particularly crucial role in mediating protein-protein interactions. Using these components as a basis, we develop a model for protein-protein interactions driven by PBDs. Our approach revises a previously …
-
Growth Factor Delivery From Fibrin Matrics Containing Affinity-Based Delivery Systems To Treat Peripheral Nerve Injury
… Evaluation of affinity-based delivery using peptides with varying binding affinity for heparin determined that peptide binding affinity for heparin affected the release rate and biological activity of nerve growth factor: NGF) in vitro. The ABDS presented biologically active NGF, which …
-
Interactions between the TatBC complex and Tat signal peptides during protein transport by the bacterial Tat pathway
… to the Tat machinery via N-terminal signal peptides that have a tripartite structure, with a polar n-region, a hydrophobic h-region and a polar c-region. They critically contain an almost invariant twin-arginine (RR) motif within the n-region that is essential to trigger Tat transport. Tat …
-
Viral subversion of host cell membrane trafficking
… Co-crystal structures of NTD bound to HDAg-L peptides derived from different HDV genotypes revealed that HDV interacts with multiple binding sites on NTD promiscuously, prompting re-evaluation of the binding between cellular peptides and NTD. Surprisingly, co-crystal structures and pull-down …
-
Strategies for Computational Protein Design with Application to the Development of a Biomolecular Tool-kit for Single Molecule Protein Sequencing
… and specificities for small-molecule and peptide binding partners. To improve the success rate of rational, computational protein design and widen the scope of potential applications, it is useful to define generalized strategies and automated methodology to improve and/or alter the …
Page 1 of 4