Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Peptide Amphiphiles"”.
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RGD based peptide amphiphiles as drug carriers for cancer targeting
… attractive target for cancer chemotherapy. The peptide sequence for this integrin recognition is the Arg-Gly-Asp (RGD). Self-assembly offers a unique way of presenting ligands to target receptors for recognition and binding. This study focuses on development of integrin specific peptide …
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Enzyme responsive nanomaterials for cancer applications
… material properties to influence cancer cells. Peptide amphiphiles were designed (PhAc-FFAGLDD (1a) and GFFLGLDD (2a) and their expected products of enzyme cleavage PhAc-FFAG (1b) and GFFLG (2b)) such that, upon cleavage by a disease-associated enzyme, reconfigure from micellar aggregates to …
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Pro-Angiogenic Self-Assembling Peptides
Peptide amphiphiles (PAs), peptides that self-assemble into hydrogels with a nanofibrous network, are interesting biomaterials due to their biocompatibility and biodegradability. Self-assembling peptide-based materials include a wide range of peptide motifs that form one-dimensional nanostructures …
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Self-assembling amphiphilic peptides: A novel approach to create new drug systems and three-dimensional scaffolds for tissue regeneration. A resourceful mine not yet fully explored
… such as amino acids, nucleic acids and lipids. Peptide-based nanostructures constitute a novel route to create well organized self-assembled materials that eventually can be used in a variety of different fields. They can be divided in different classes based on the architecture of the overall …
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Development of Transferable Coarse-Grained Models of Amino Acids
… and biomaterials such as proteins and peptide amphiphiles (PAs). The focus of this study was to develop accurate transferable coarse-grained (CG) models of those amino acids. In CG models, several atoms are represented together as a single pseudo-atom or "bead," which can allow the …
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Peptide Mediated Co-assembly of Porphyrin: Towards Sustainable Biomaterials for Light Harvesting and Catalysis
… the same or similar function as proteins. Short peptides and aromatic peptide amphiphiles (2-5 amino acids short) are ideal candidates to generate minimalistic functional versions of complicated biological systems with same function and biocompatibility.</p> <p>Thermodynamically driven fully …
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Engineering delivery systems for the treatment of Non-Hodgkin lymphoma
… follow-on disease. To address this issue, peptides have emerged in recent years as a novel improvement in cancer treatment, however, these drugs are limited by their poor cell penetration and serum instability. Lipidation of peptides, producing peptide amphiphiles, has been shown to allow …
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Structure, dynamics and applications of peptide-based nanomaterials
Peptide-based nanomaterials have rapidly gained interest over the last 10 years, because of their potential uses in biomedicine, nanotechnology and catalysis. Short peptides can readily self-assemble into ordered structures on the nanometer length scale. The design rules for these constructs are …
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Mechanistic studies to evaluate the targeting specificity of novel RGD Micelles to the αVβ3 integrin receptor
… to nanosystem drug delivery is with the use of peptide amphiphiles (PAs) that are conjugated with the Arginine-Glycine-Aspartic Acid (RGD) motif to actively target a <strong>αVβ3</strong> integrin receptors on cancer cells or tumor endothelium. The current work is focused on mechanistic studies …
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A computer-simulation-based molecular-thermodynamic model for shape-based screening of peptide amphiphile micelles in vaccines
Peptide amphiphiles (PAs) and their self-assembled aggregates, peptide amphiphile micelles (PAMs), have garnered considerable attention as a platform for biomedical applications due to their unique combination of biocompatibility, modular functionality, and tailorable size and shape. Since PAMs …
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Dynamic supramolecular hydrogels with adaptive biological functionality
… self-assembly and biocatalysis. Aromatic peptide amphiphiles and aromatic sugar amphiphiles are particularly interesting building blocks in this context and were mainly utilised in this work. For the development of applications and novel uses for peptide nanostructures, robust routes for …
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In vivo responses of neural progenitor cells to extracellular matrix signaling under pathological conditions
… In paper I, we use an injectable self-assembling peptide amphiphile coupled to a migration-inducing peptide sequence derived from Tenascin-C, a glycoprotein natural occurring in the extracellular matrix of the neuro-genic areas. In this paper, we re-directed cells from their normal path, the …