Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Peptide Amphiphile"”.
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A computer-simulation-based molecular-thermodynamic model for shape-based screening of peptide amphiphile micelles in vaccines
Peptide amphiphiles (PAs) and their self-assembled aggregates, peptide amphiphile micelles (PAMs), have garnered considerable attention as a platform for biomedical applications due to their unique combination of biocompatibility, modular functionality, and tailorable size and shape. Since PAMs …
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Engineering delivery systems for the treatment of Non-Hodgkin lymphoma
… follow-on disease. To address this issue, peptides have emerged in recent years as a novel improvement in cancer treatment, however, these drugs are limited by their poor cell penetration and serum instability. Lipidation of peptides, producing peptide amphiphiles, has been shown to allow …
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Self-assembling amphiphilic peptides: A novel approach to create new drug systems and three-dimensional scaffolds for tissue regeneration. A resourceful mine not yet fully explored
… such as amino acids, nucleic acids and lipids. Peptide-based nanostructures constitute a novel route to create well organized self-assembled materials that eventually can be used in a variety of different fields. They can be divided in different classes based on the architecture of the overall …
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RGD based peptide amphiphiles as drug carriers for cancer targeting
… attractive target for cancer chemotherapy. The peptide sequence for this integrin recognition is the Arg-Gly-Asp (RGD). Self-assembly offers a unique way of presenting ligands to target receptors for recognition and binding. This study focuses on development of integrin specific peptide …
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Self-assembled Peptide Hydrogels for Therapeutic H2S Delivery
… compound, were synthesized and conjugated to peptide sequences to form H2S-releasing aromatic peptide amphiphile (APA) hydrogels. APAs formed nanofibers, which were stabilized by beta-sheets and aromatic stacking. The self-assembled structures were affected by the substituents on the aromatic …
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The Development of Novel Platforms for the Imaging of Cancer by Positron Emission Tomography
<p>The role of antibody-based imaging of cancer by positron emission tomography (PET) has expanded significantly in recent years and is poised to radically alter the way that cancer is diagnosed and treated. However, one hurdle that remains is the potentially harmful radiation dose that comes from …
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DIFFERENTIATION OF NEURAL STEM CELL USING SMALL MOLECULES IN 2D AND 3D CULTURE SYSTEM
The neuronal differentiation of neural stem cells (NSCs) has received much attention due to its potential for the treatment of neurodegenerative diseases (i.e., Parkinson’s and Alzheimer’s diseases). In this regard, discovering compounds that direct differentiation of NSCs is highly required to …
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Exploring Critical Vehicle Parameters for the Design of Multitargeted Nanoparticles for Cancer Specific Gene Delivery
… siRNA were functionalized with a targeting peptide which binds to the alpha6 integrin, a cervical cancer biomarker. It was found that both targeting and polymer complexation before encapsulation were critical components to effective transfection. Varying the siRNA:polymer ratio revealed an …