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Showing 1 to 12 of 12 for “"Pentoxifylline"”.
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Pharmacokinetics and pharmacodynamics of pentoxifylline and metabolites
Pentoxifylline is a haemorheologic drug with complex pharmacokinetics and pharmacodynamics due to both reversible metabolism and the formation of active metabolites. In humans, pentoxifylline is metabolised to at least seven phase 1 metabolites (M1-M7). The reversible metabolism of pentoxifylline …
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Effects of pentoxifylline on exercising skeletal muscle vascular control in rats with chronic heart failure
… pharmaceutical TNF-[alpha] synthesis suppressor pentoxifylline (PTX) reduces plasma [TNF-[alpha]] and improves left ventricular (LV) function in CHF rats, but the effects of PTX on skeletal muscle blood flow (BF) and vascular conductance (VC) during exercise are unknown. We tested the hypothesis …
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Combinatorial therapy for triple negative breast cancer and the effect of nanoscale surfaces
… pathways. An additional incorporation of pentoxifylline, a methylxanthine derivative known for anti-metastatic effects in breast cancers, could further improve the efficiency. We used drug combination of nifuroxazide, amonafide and pentoxifylline in MDA-MB-231, HCC1806, HCC1143 and BT-549 …
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Matrix metalloproteinases in the equine systemic inflammatory response: implications for equine laminitis
… oxytetracycline, flunixin meglumine, and pentoxifylline on equine MMP inhibition. Pentoxifylline and oxytetracycline appeared to be potent MMP-9 and modest MMP-2 inhibitors in the horse. Flunixin meglumine and doxycycline were potent inhibitors of equine MMP-2, but only weak inhibitors of …
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Evaluation of the antinociceptive, anti-inflammatory and antipyretic activities of Ruta Graveolens L. in mice and rats
… over the 5 h period of testing. In addition, pentoxifylline (50 mg/kg, i.p.) significantly reduced E. coliinduced pyrexia. Ruta graveolens (25 – 50 mg/kg, i.p.), paracetamol (500 mg/kg, i.p.) and pentoxifylline (10 mg/kg, i.p.) did not significantly reduce pyrexia induced by E. coli.However, …
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Cryopreservation of Domestic Cat Epididymal Spermatozoa
… and after freezing, to 0nM, 1nM and 5nM of pentoxifylline (a motility stimulant) would have an effect on the post-thaw parameters measured. It was determined that there was no significant in post-thaw sperm motility, membrane integrity or acrosomal status when the epididymal sperm were …
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Identification of macrophage phenotypes and evaluation of their role in the immunopathogenesis in animal model of Behçet’s disease
… of IL-4. Furthermore, colchicine and pentoxifylline, which are frequently prescribed BD medications, decreased the M1/M2 ratio and improved BD-like symptoms in mice. This study clearly demonstrates the correlation of the M1 and M2 macrophage phenotypes and the M1/M2 ratio with …
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Microfluidic devices for analysis of red blood cell mechanical properties
… (2) and spherocytosis (3)), drug exposure (e.g. pentoxifylline (4)), and disease (e.g. diabetes (5) and malaria (6)). Within the past 15 years, microfabrication techniques have enabled the creation of pores comparable in size and shape to the smallest human capillaries (7) and slits in the spleen …
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Choline Acetyltransferase and Carnitine Acetyltransferase Activity in Human Spermatozoa During Capacitation
… was observed when using both caffeine and pentoxifylline. The addition of caffeine significantly increased equatorial binding, midpiece/tail binding, and the acrosome reaction rate in both washed and post swim-up samples. Although the addition of caffeine increased both equatorial binding …
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Development of artificial eardrums using water-soluble chitosan and tissue engineering techniques
… Nowadays several materials like hyaluronic acid, pentoxifylline, EGF, bFGF, AlloDerm are applied to treatment of ear drum perforation. Paper patch is the most widely used material but it is not resorbable and myringoplasty needs relatively complex procedures than usual OPD based treatment. So, we …
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The role of oxygen free radicals in the endotoxic shock induced myocardial dysfunction and cellular injury
… (flax seed), (f) ET+cytokine inhibitor (pentoxifylline (PTF)). Hemodynamic parameters were measured before and at various times after ET administration to determine myocardial function and contractility and myocardial oxygen consumption. Blood samples were collected at similar intervals …
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Role of second generation phosphodiesterase inhibitors on mammalian sperm mobility
… phosphodiesterase inhibitors (PDEi), such as pentoxifylline, were shown to enhance motility of human spermatozoa; however, contradictory results and stimulation of premature acrosome reaction has precluded their clinical use. Advancement in our knowledge have now made it clear that human sperm …